PDB: 760 件ウェブページステータス検索Chemie searchBIRD

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7B02	Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid 分子名称: 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Fata, F, Silvestri, I, Williams, D.L, Angelucci, F. 登録日 2020-11-18 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. Acs Infect Dis., 7, 2021
2XC2	Crystal structure of oxidized Schistosoma mansoni Thioredoxin pre- protein at 1.6 Angstrom 分子名称: CALCIUM ION, THIOREDOXINN, ZINC ION 著者 Boumis, G, Miele, A.E, Dimastrogiovanni, D, Angelucci, F, Bellelli, A. 登録日 2010-04-15 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural and Functional Characterization of Schistosoma Mansoni Thioredoxin. Protein Sci., 20, 2011
2XBQ	Crystal structure of reduced Schistosoma mansoni Thioredoxin pre- protein at 1.7 Angstrom 分子名称: THIOREDOXIN, ZINC ION 著者 Boumis, G, Miele, A.E, Dimastrogiovanni, D, Angelucci, F, Bellelli, A. 登録日 2010-04-14 公開日 2010-07-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structural and Functional Characterization of Schistosoma Mansoni Thioredoxin. Protein Sci., 20, 2011
6ZST	Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid 分子名称: 3-(3-methoxyquinoxalin-2-yl)propanoic acid, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Fata, F, Silvestri, I, Williams, D.L, Angelucci, F. 登録日 2020-07-16 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. Acs Infect Dis., 7, 2021
6ZP3	Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 2-Methylindole-3-acetic acid 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(2-methyl-1~{H}-indol-3-yl)ethanoic acid, CALCIUM ION, ... 著者 Fata, F, Silvestri, I, Williams, D.L, Angelucci, F. 登録日 2020-07-08 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. Acs Infect Dis., 7, 2021
6ZLP	Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 4-Aminopiazthiole 分子名称: 2,1,3-benzothiadiazol-4-amine, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Fata, F, Silvestri, I, Williams, D.L, Angelucci, F. 登録日 2020-06-30 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. Acs Infect Dis., 7, 2021
3AB1	Crystal Structure of Ferredoxin NADP+ Oxidoreductase 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Ferredoxin--NADP reductase 著者 Muraki, N, Seo, D, Kurisu, G. 登録日 2009-11-30 公開日 2010-11-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Asymmetric dimeric structure of ferredoxin-NAD(P)+ oxidoreductase from the green sulfur bacterium Chlorobaculum tepidum: implications for binding ferredoxin and NADP+ J.Mol.Biol., 401, 2010
4N8R	Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 分子名称: 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-17 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
4N5G	Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 分子名称: 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-09 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
1T8E	T7 DNA Polymerase Ternary Complex with dCTP at the Insertion Site. 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 25-MER, ... 著者 Brieba, L.G, Eichman, B.F, Kokoska, R.J, Doublie, S, Kunkel, T.A, Ellenberger, T. 登録日 2004-05-12 公開日 2004-10-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. Embo J., 23, 2004
3UJ1	Crystal structure of the third thioredoxin domain of human ERp46 分子名称: Thioredoxin domain-containing protein 5 著者 Parthier, C, Funkner, A, Ferrari, D.M, Stubbs, M.T. 登録日 2011-11-07 公開日 2012-11-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.651 Å) 主引用文献 Peptide Binding by Catalytic Domains of the Protein Disulfide Isomerase-Related Protein ERp46. J.Mol.Biol., 425, 2013
7E52	Acinetobacter baumannii Thioredoxin reductase 分子名称: Thioredoxin reductase 著者 Park, H.H, Chun, H.L. 登録日 2021-02-16 公開日 2022-02-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Acinetobacter baumannii Thioredoxin reductase To Be Published
5NVD	Crystal structure of hexameric CBS-CP12 protein from bloom-forming cyanobacteria at 2.5 A resolution in P6322 crystal form 分子名称: CBS-CP12 著者 Hackenberg, C, Hakanpaa, J, Eigner, C, Antonyuk, S.V, Dittmann, E, Lamzin, V.S. 登録日 2017-05-04 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6KIZ	Cryo-EM structure of human MLL1-NCP complex, binding mode2 分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIX	Cryo-EM structure of human MLL1-NCP complex, binding mode1 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIV	Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) 分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIU	Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
8CCK	Crystal structure of Mycobacterium smegmatis thioredoxin reductase in complex with fragment F2X-Entry H07 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Fuesser, F.T, Koch, O, Kuemmel, D. 登録日 2023-01-27 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Fragment-based design of mycobacterial thioredoxin reductase inhibitors based on computational exploration of a huge virtual space To Be Published
8CCJ	Crystal structure of Mycobacterium smegmatis thioredoxin reductase in complex with NADPH 分子名称: DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Fuesser, F.T, Koch, O, Kuemmel, D. 登録日 2023-01-27 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-based design of mycobacterial thioredoxin reductase inhibitors based on computational exploration of a huge virtual space To Be Published
8CCL	Crystal structure of Mycobacterium smegmatis thioredoxin reductase in complex with fragment F2X-Entry A09 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Fuesser, F.T, Koch, O, Kuemmel, D. 登録日 2023-01-27 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-based design of mycobacterial thioredoxin reductase inhibitors based on computational exploration of a huge virtual space To Be Published
8CCM	Crystal structure of Mycobacterium smegmatis thioredoxin reductase in complex with Compound 2-06 分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Fuesser, F.T, Koch, O, Kuemmel, D. 登録日 2023-01-27 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment-based design of mycobacterial thioredoxin reductase inhibitors based on computational exploration of a huge virtual space To Be Published
6Z9C	Structure of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability 分子名称: Polymerase delta-interacting protein 2, SODIUM ION 著者 Kulik, A.A, Maruszczak, K, Nabi, N.L.M, Bingham, R.J, Cooper, C.D.O. 登録日 2020-06-03 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure and molecular dynamics of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability. Protein Sci., 30, 2021
6W5I	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) 分子名称: DNA (147-MER), Histone H2A, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5N	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5M	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021

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