7L2J
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![BU of 7l2j by Molmil](/molmil-images/mine/7l2j) | Cryo-EM structure of full-length TRPV1 at pH6c state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, Transient receptor potential cation channel subfamily V member 1 | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2I
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![BU of 7l2i by Molmil](/molmil-images/mine/7l2i) | Cryo-EM structure of full-length TRPV1 at pH6a state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1S,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, Transient receptor potential cation channel subfamily V member 1 | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2H
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![BU of 7l2h by Molmil](/molmil-images/mine/7l2h) | Cryo-EM structure of unliganded full-length TRPV1 at neutral pH | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl tridecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7K4F
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![BU of 7k4f by Molmil](/molmil-images/mine/7k4f) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 31 | 分子名称: | 5-[(4-{cis-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K4E
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![BU of 7k4e by Molmil](/molmil-images/mine/7k4e) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30 | 分子名称: | 5-({4-[(1R,4S)-3'-methyl[1,2,3,4-tetrahydro[1,1'-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.34 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K4D
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![BU of 7k4d by Molmil](/molmil-images/mine/7k4d) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG | 分子名称: | 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K4C
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![BU of 7k4c by Molmil](/molmil-images/mine/7k4c) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a | 分子名称: | 1-(5-bromopyridin-3-yl)-4-[cis-4-(3-methylphenyl)cyclohexyl]piperazine, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K4B
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![BU of 7k4b by Molmil](/molmil-images/mine/7k4b) | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl)piperazine, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K4A
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![BU of 7k4a by Molmil](/molmil-images/mine/7k4a) | Cryo-EM structure of human TRPV6 in the open state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2020-09-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7K48
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![BU of 7k48 by Molmil](/molmil-images/mine/7k48) | Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a | 著者 | Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A. | 登録日 | 2020-09-15 | 公開日 | 2020-12-02 | 最終更新日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin. Mol.Cell, 81, 2021
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7K18
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![BU of 7k18 by Molmil](/molmil-images/mine/7k18) | Cardiac Sodium channel with toxin bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... | 著者 | Jiang, D, Catterall, W.A. | 登録日 | 2020-09-07 | 公開日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin. Nat Commun, 12, 2021
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7JUP
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![BU of 7jup by Molmil](/molmil-images/mine/7jup) | Structure of human TRPA1 in complex with antagonist compound 21 | 分子名称: | 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L. | 登録日 | 2020-08-20 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J.Med.Chem., 64, 2021
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7JPX
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![BU of 7jpx by Molmil](/molmil-images/mine/7jpx) | Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom resolution | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | 著者 | Yan, N, Gao, S. | 登録日 | 2020-08-10 | 公開日 | 2020-11-18 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*. Angew.Chem.Int.Ed.Engl., 60, 2021
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7JPW
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![BU of 7jpw by Molmil](/molmil-images/mine/7jpw) | Rabbit Cav1.1 in the presence of 100 micromolar (R)-(+)-Bay K8644 in nanodiscs at 3.2 Angstrom resolution | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ... | 著者 | Yan, N, Gao, S. | 登録日 | 2020-08-10 | 公開日 | 2020-11-18 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*. Angew.Chem.Int.Ed.Engl., 60, 2021
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7JPV
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![BU of 7jpv by Molmil](/molmil-images/mine/7jpv) | Rabbit Cav1.1 in the presence of 1 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom resolution | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ... | 著者 | Yan, N, Gao, S. | 登録日 | 2020-08-10 | 公開日 | 2020-11-18 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*. Angew.Chem.Int.Ed.Engl., 60, 2021
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7JPL
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![BU of 7jpl by Molmil](/molmil-images/mine/7jpl) | Rabbit Cav1.1 in the presence of 10 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom resolution | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ... | 著者 | Yan, N, Gao, S. | 登録日 | 2020-08-09 | 公開日 | 2020-11-18 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*. Angew.Chem.Int.Ed.Engl., 60, 2021
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7JPK
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![BU of 7jpk by Molmil](/molmil-images/mine/7jpk) | Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0 Angstrom resolution | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, CALCIUM ION, ... | 著者 | Yan, N, Gao, S. | 登録日 | 2020-08-09 | 公開日 | 2020-11-18 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*. Angew.Chem.Int.Ed.Engl., 60, 2021
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7FHO
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![BU of 7fho by Molmil](/molmil-images/mine/7fho) | Structure of AtTPC1 D240A/D454A/E528A mutant with 50 mM Ca2+ | 分子名称: | CALCIUM ION, Two pore calcium channel protein 1,GFP | 著者 | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHN
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![BU of 7fhn by Molmil](/molmil-images/mine/7fhn) | Structure of AtTPC1 D240A/D454A/E528A mutant with 1 mM Ca2+ | 分子名称: | CALCIUM ION, Two pore calcium channel protein 1,GFP | 著者 | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHL
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![BU of 7fhl by Molmil](/molmil-images/mine/7fhl) | Structure of AtTPC1 with 50 mM Ca2+ | 分子名称: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | 著者 | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHK
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![BU of 7fhk by Molmil](/molmil-images/mine/7fhk) | Structure of AtTPC1 with 1 mM Ca2+ | 分子名称: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | 著者 | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FCV
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![BU of 7fcv by Molmil](/molmil-images/mine/7fcv) | Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana | 分子名称: | PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1 | 著者 | Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L. | 登録日 | 2021-07-15 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis. Nat Commun, 13, 2022
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7FBS
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![BU of 7fbs by Molmil](/molmil-images/mine/7fbs) | structure of a channel | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D.J, Catterall, W.A. | 登録日 | 2021-07-12 | 公開日 | 2021-09-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Open-state structure and pore gating mechanism of the cardiac sodium channel. Cell, 184, 2021
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7F3F
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![BU of 7f3f by Molmil](/molmil-images/mine/7f3f) | CryoEM structure of human Kv4.2-KChIP1 complex | 分子名称: | Isoform 2 of Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | 著者 | Kise, Y, Nureki, O. | 登録日 | 2021-06-16 | 公開日 | 2021-10-13 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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7F0J
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![BU of 7f0j by Molmil](/molmil-images/mine/7f0j) | CryoEM structure of human Kv4.2 | 分子名称: | Potassium voltage-gated channel subfamily D member 2, ZINC ION | 著者 | Kise, Y, Nureki, O. | 登録日 | 2021-06-04 | 公開日 | 2021-10-13 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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