PDB: 1328 件ウェブページステータス検索Chemie searchBIRD

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2ERX	Crystal Structure of DiRas2 in Complex With GDP and Inorganic Phosphate 分子名称: GTP-binding protein Di-Ras2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Papagrigoriou, E, Yang, X, Elkins, J, Niesen, F.E, Burgess, N, Salah, E, Fedorov, O, Ball, L.J, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Doyle, D. 登録日 2005-10-25 公開日 2005-11-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal Structure of DiRas2 To be Published
2EVW	Crystal structure analysis of a fluorescent form of H-Ras p21 in complex with R-caged GTP 分子名称: GTPase HRas, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION, ... 著者 Klink, B.U. 登録日 2005-11-01 公開日 2006-05-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. Biophys.J., 91, 2006
2F7S	The crystal structure of human Rab27b bound to GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-27B 著者 Wang, J, Ismail, S, Shen, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) 登録日 2005-12-01 公開日 2005-12-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The crystal structure of human Rab27b To be Published
4JS0	Complex of Cdc42 with the CRIB-PR domain of IRSp53 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, Cell division control protein 42 homolog, ... 著者 Kast, D.J, Dominguez, R. 登録日 2013-03-22 公開日 2014-03-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nat.Struct.Mol.Biol., 21, 2014
7JIF	HRAS A59T GppNHp 分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Haigis, K.M. 登録日 2020-07-23 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.757 Å) 主引用文献 Regulation of GTPase function by autophosphorylation. Mol.Cell, 82, 2022
7JII	HRAS A59E GDP 分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Johnson, C.W, Haigis, K.M. 登録日 2020-07-23 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.532 Å) 主引用文献 Regulation of GTPase function by autophosphorylation. Mol.Cell, 82, 2022
7JIH	HRAS A59E GppNHp 分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Haigis, K.M. 登録日 2020-07-23 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.989 Å) 主引用文献 Regulation of GTPase function by autophosphorylation. Mol.Cell, 82, 2022
7JIG	HRAS A59T GppNHp crystal 2 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Johnson, C.W, Haigis, K.M. 登録日 2020-07-23 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.322 Å) 主引用文献 Regulation of GTPase function by autophosphorylation. Mol.Cell, 82, 2022
4L9W	Crystal Structure of H-Ras G12C, GMPPNP-bound 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-06-18 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4L8G	Crystal Structure of K-Ras G12C, GDP-bound 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-06-17 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.521 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LDJ	Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2013-06-24 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
4LHV	Crystal structure of Rab8 in its inactive GDP-bound form 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-8A 著者 Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. 登録日 2013-07-01 公開日 2013-10-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
4LHW	Crystal structure of Rab8 in its active GppNHp-bound form 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. 登録日 2013-07-01 公開日 2013-10-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
4L9S	Crystal Structure of H-Ras G12C, GDP-bound 分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-06-18 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.606 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1Y	Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(5,7-dichloro-2,1,3-benzothiadiazol-4-yl)glycyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-04 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.491 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4KLZ	Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis 分子名称: GTP-binding protein Rit1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Shah, D.M, Kobayashi, M, Keizers, P.H, Tuin, A.W, Ab, E, Manning, L, Rzepiela, A.A, Andrews, M, Hoedemaeker, F.J, Siegal, G. 登録日 2013-05-07 公開日 2014-09-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis To be Published
4LYH	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4-chloro-5-iodo-2-methoxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.371 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M22	Crystal Structure of small molecule acrylamide 16 covalently bound to K-Ras G12C 分子名称: 1-{4-[(2,4-dichlorophenoxy)acetyl]piperazin-1-yl}propan-1-one, GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-05 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4LYJ	Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.927 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
7L0G	Monobody 12VC1 Bound to HRAS(G12C) 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase HRas, MAGNESIUM ION, ... 著者 Teng, K.W, Hattori, T, Tsai, S, Koide, S. 登録日 2020-12-11 公開日 2021-03-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun, 12, 2021
7L0F	Monobody 12VC3 Bound to HRAS(WT) 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase HRas, MAGNESIUM ION, ... 著者 Teng, K.W, Hattori, T, Tsai, S, Koide, S. 登録日 2020-12-11 公開日 2021-03-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun, 12, 2021
4LYF	Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4,5-dichloro-2-hydroxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-07-31 公開日 2013-11-27 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.568 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M21	Crystal Structure of small molecule acrylamide 11 covalently bound to K-Ras G12C 分子名称: 1-(4-{[(4,5-dichloro-2-methoxyphenyl)amino]acetyl}piperazin-1-yl)propan-1-one, GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-05 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
4M1W	Crystal Structure of small molecule vinylsulfonamide covalently bound to K-Ras G12C 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, MAGNESIUM ION, ... 著者 Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. 登録日 2013-08-04 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
7KMR	Crystal structure analysis of human KRAS mutant 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2020-11-03 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Regulation of GTPase function by autophosphorylation. Mol.Cell, 82, 2022

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