PDB: 694 件ウェブページステータス検索Chemie searchBIRD

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6NJM	Architecture and subunit arrangement of native AMPA receptors 分子名称: 15F1 Fab heavy chain, 15F1 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gouaux, E, Zhao, Y. 登録日 2019-01-03 公開日 2019-04-24 最終更新日 2021-05-05 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Science, 364, 2019
3FV2	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with neodysiherbaine A in space group P1 分子名称: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... 著者 Unno, M, Sasaki, M, Ikeda-Saito, M. 登録日 2009-01-15 公開日 2010-01-19 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3T93	Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.907 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3G3H	Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
6LU9	Rat ionotropic Glutamate Delta-2 receptor in complex with 7-CKA and Calcium 分子名称: Glutamate receptor ionotropic, delta-2 著者 Kumar, J, Burada, A.P. 登録日 2020-01-27 公開日 2020-06-17 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (8.8 Å) 主引用文献 The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. J.Struct.Biol., 211, 2020
3TDJ	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution 分子名称: 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, GLUTAMIC ACID, ... 著者 Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-08-11 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
3T9U	CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3GBA	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A resolution 分子名称: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2009-02-19 公開日 2009-03-17 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3G3I	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with glutamate and NaCl at 1.37 Angstrom resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Chaudhry, C, Mayer, M.L. 登録日 2009-02-02 公開日 2009-06-02 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.371 Å) 主引用文献 Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3DP4	Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA 分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. 登録日 2008-07-07 公開日 2008-11-25 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
3GBB	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution 分子名称: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, Glutamate receptor, ionotropic kainate 1 著者 Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2009-02-19 公開日 2009-03-17 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3U92	Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2011-10-17 公開日 2012-09-26 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron, 76, 2012
3TKD	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution 分子名称: CYCLOTHIAZIDE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... 著者 Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-08-26 公開日 2011-09-21 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
3H06	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 分子名称: 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid, Glutamate receptor 2 著者 Ahmed, A.H, Oswald, R.E. 登録日 2009-04-08 公開日 2009-05-05 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H03	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 分子名称: 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2009-04-08 公開日 2009-05-05 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H6W	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution 分子名称: (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Hald, H, Gajhede, M, Kastrup, J.S. 登録日 2009-04-24 公開日 2009-07-28 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3TZA	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution 分子名称: (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, Glutamate receptor 2,Glutamate receptor 2, SULFATE ION 著者 Frydenvang, K, Kastrup, J.S. 登録日 2011-09-27 公開日 2011-10-26 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure J.Med.Chem., 54, 2011
3U94	Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P21212 form 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2011-10-17 公開日 2012-09-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.962 Å) 主引用文献 Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron, 76, 2012
3U93	Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P2221 form 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2011-10-17 公開日 2012-09-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.881 Å) 主引用文献 Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron, 76, 2012
5H8N	Structure of the human GluN1/GluN2A LBD in complex with NAM 分子名称: 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide, CALCIUM ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5I59	Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 分子名称: 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ... 著者 Mou, T.-C, Sprang, S.R, Hansen, K.B. 登録日 2016-02-14 公開日 2016-09-21 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
5I2K	Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19) 分子名称: 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, GLUTAMIC ACID, GLYCINE, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2016-02-09 公開日 2016-03-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59, 2016
5IDE	Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I) 分子名称: Glutamate receptor 2, Glutamate receptor 3 著者 Herguedas, B, Garcia-Nafria, J, Fernandez-Leiro, R, Greger, I.H. 登録日 2016-02-24 公開日 2016-03-16 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (8.25 Å) 主引用文献 Structure and organization of heteromeric AMPA-type glutamate receptors. Science, 352, 2016
5IPT	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 5 分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a 著者 Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. 登録日 2016-03-09 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (14.1 Å) 主引用文献 Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
5I56	Agonist-bound GluN1/GluN2A agonist binding domains with TCN201 分子名称: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... 著者 Mou, T.-C, Sprang, S.R, Hansen, K.B. 登録日 2016-02-14 公開日 2016-09-07 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016

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