PDB: 30476 件ウェブページステータス検索Chemie searchBIRD

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4BPU	Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain. 分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, GLYCEROL, ... 著者 Kilkenny, M.L, Perera, R.L, Pellegrini, L. 登録日 2013-05-28 公開日 2013-09-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering Proc.Natl.Acad.Sci.USA, 110, 2013
4BY2	SAS-4 (dCPAP) TCP domain in complex with a Proline Rich Motif of Ana2 (dSTIL) of Drosophila Melanogaster 分子名称: 1,2-ETHANEDIOL, ANASTRAL SPINDLE 2, SAS 4 著者 Cottee, M.A, Muschalik, N, Wong, Y.L, Johnson, C.M, Johnson, S, Andreeva, A, Oegema, K, Lea, S.M, Raff, J.W, van Breugel, M. 登録日 2013-07-17 公開日 2013-09-18 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly. Elife, 2, 2013
4C95	Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Sld5 分子名称: DNA POLYMERASE ALPHA-BINDING PROTEIN, DNA REPLICATION COMPLEX GINS PROTEIN SLD5 著者 Simon, A.C, Pellegrini, L. 登録日 2013-10-02 公開日 2014-04-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.694 Å) 主引用文献 A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome Nature, 510, 2014
4CBP	Crystal structure of neural ectodermal development factor IMP-L2. 分子名称: GLYCEROL, NEURAL/ECTODERMAL DEVELOPMENT FACTOR IMP-L2 著者 Kulahin, N, Kristensen, O, Brzozowski, M, Schluckebier, G, Meyts, P.D. 登録日 2013-10-15 公開日 2014-10-29 最終更新日 2019-05-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Analysis of Imp-L2 Function To be Published
4C33	PKA-S6K1 Chimera Apo 分子名称: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA 著者 Couty, S, Westwood, I.M, Kalusa, A, Cano, C, Travers, J, Boxall, K, Chow, C.L, Burns, S, Schmitt, J, Pickard, L, Barillari, C, McAndrew, P.C, Clarke, P.A, Linardopoulos, S, Griffin, R.J, Aherne, G.W, Raynaud, F.I, Workman, P, Jones, K, van Montfort, R.L.M. 登録日 2013-08-21 公開日 2013-10-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, 4, 2013
4BXW	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis 分子名称: COAGULATION FACTOR V, FACTOR XA, GLYCEROL, ... 著者 Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A. 登録日 2013-07-16 公開日 2013-07-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis. Blood, 122, 2013
4C4I	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1 分子名称: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-{[2-chloro-4-(dimethylcarbamoyl)phenyl]amino}-2-(1,3-oxazol-5-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 著者 Naud, S, Westwood, I.M, Faisal, A, Sheldrake, P, Bavetsias, V, Atrash, B, Liu, M, Hayes, A, Schmitt, J, Wood, A, Choi, V, Boxall, K, Mak, G, Gurden, M, Valenti, M, de Haven Brandon, A, Henley, A, Baker, R, McAndrew, C, Matijssen, B, Burke, R, Eccles, S.A, Raynaud, F.I, Linardopoulos, S, van Montfort, R, Blagg, J. 登録日 2013-09-05 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1). J.Med.Chem., 56, 2013
4C9J	Structure of yeast mitochondrial ADP/ATP carrier isoform 3 inhibited by carboxyatractyloside (P212121 crystal form) 分子名称: ADP, ATP CARRIER PROTEIN 3, CARDIOLIPIN, ... 著者 Ruprecht, J.J, Hellawell, A.M, Harding, M, Crichton, P.G, McCoy, A.J, Kunji, E.R.S. 登録日 2013-10-02 公開日 2014-01-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.397 Å) 主引用文献 Structures of Yeast Mitochondrial Adp/ATP Carriers Support a Domain-Based Alternating-Access Transport Mechanism Proc.Natl.Acad.Sci.USA, 111, 2014
4C9W	Crystal structure of NUDT1 (MTH1) with R-crizotinib 分子名称: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, ... 著者 Elkins, J.M, Salah, E, Huber, K, Superti-Furga, G, Abdul Azeez, K.R, Raynor, J, Krojer, T, von Delft, F, Bountra, C, Edwards, A, Knapp, S. 登録日 2013-10-03 公開日 2014-04-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy. Nature, 508, 2014
4CBC	Open-form NavMS Sodium Channel Pore (with C-terminal Domain) after thallium soak 分子名称: HEGA-10, ION TRANSPORT PROTEIN, SODIUM ION 著者 Bagneris, C, Naylor, C.E, Wallace, B.A. 登録日 2013-10-12 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.664 Å) 主引用文献 Prokaryotic Navms Channel as a Structural and Functional Model for Eukaryotic Sodium Channel Antagonism. Proc.Natl.Acad.Sci.USA, 111, 2014
4C9H	Structure of yeast mitochondrial ADP/ATP carrier isoform 2 inhibited by carboxyatractyloside (P212121 crystal form) 分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ADP, ATP CARRIER PROTEIN 2, ... 著者 Ruprecht, J.J, Hellawell, A.M, Harding, M, Crichton, P.G, McCoy, A.J, Kunji, E.R.S. 登録日 2013-10-02 公開日 2014-01-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structures of Yeast Mitochondrial Adp/ATP Carriers Support a Domain-Based Alternating-Access Transport Mechanism Proc.Natl.Acad.Sci.USA, 111, 2014
4C08	Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.34 Angstroms 分子名称: CALCIUM ION, PENTAETHYLENE GLYCOL, PROTEIN ARGININE N-METHYLTRANSFERASE 6 著者 Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. 登録日 2013-07-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.338 Å) 主引用文献 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
4C4J	Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1 分子名称: DUAL SPECIFICITY PROTEIN KINASE TTK, tert-butyl 6-{[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino}-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 著者 Naud, S, Westwood, I.M, Faisal, A, Sheldrake, P, Bavetsias, V, Atrash, B, Liu, M, Hayes, A, Schmitt, J, Wood, A, Choi, V, Boxall, K, Mak, G, Gurden, M, Valenti, M, de Haven Brandon, A, Henley, A, Baker, R, McAndrew, C, Matijssen, B, Burke, R, Eccles, S.A, Raynaud, F.I, Linardopoulos, S, van Montfort, R, Blagg, J. 登録日 2013-09-05 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1). J.Med.Chem., 56, 2013
4C8D	Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B) 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Vollmar, M, Johansson, C, Gileadi, C, Goubin, S, Szykowska, A, Krojer, T, Crawley, L, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2013-09-30 公開日 2013-10-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Crystal Structure of Jmjc Domain of Human Histone 3 Lysine-Specific Demethylase 3B (Kdm3B) To be Published
4BW5	Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CADMIUM ION, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, ... 著者 Pike, A.C.W, Dong, Y.Y, Dong, L, Quigley, A, Shrestha, L, Mukhopadhyay, S, Strain-Damerell, C, Goubin, S, Grieben, M, Shintre, C.A, Mackenzie, A, Vollmar, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N, Carpenter, E.P. 登録日 2013-06-30 公開日 2013-07-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac Science, 347, 2015
4C06	Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with MgCl2 分子名称: MAGNESIUM ION, PROTEIN ARGININE N-METHYLTRANSFERASE 6 著者 Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. 登録日 2013-07-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
4C3Z	Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis. 分子名称: MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1, SULFATE ION 著者 Chaptal, V, Gueguen-Chaignon, V, Magnard, S, Falson, P, Di Pietro, A, Baubichon-Cortay, H. 登録日 2013-08-28 公開日 2014-09-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Nucleotide-Free Crystal Structure of Nucleotide-Binding Domain 1 from Human Abcc1 Supports a 'General-Base Catalysis' Mechanism for ATP Hydrolysis. Biochem.Pharm., 3, 2014
4C05	Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with SAH 分子名称: PROTEIN ARGININE N-METHYLTRANSFERASE 6, S-ADENOSYL-L-HOMOCYSTEINE 著者 Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. 登録日 2013-07-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.195 Å) 主引用文献 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
4C1I	Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System 分子名称: (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol, CGMP-DEPENDENT 3', 5'-CYCLIC PHOSPHODIESTERASE, ... 著者 Jorgensen, M, Kehler, J, Langgard, M, Svenstrup, N, Tagmose, L. 登録日 2013-08-12 公開日 2014-08-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Chapter 4: Selective Inhibitors of Pde2, Pde9, and Pde10: Modulators of Activity of the Central Nervous System To be Published
4C4W	Structure of a rare, non-standard sequence k-turn bound by L7Ae protein 分子名称: 50S RIBOSOMAL PROTEIN L7AE, DIHYDROGENPHOSPHATE ION, TSKT-23, ... 著者 Huang, L, Lilley, D.M.J. 登録日 2013-09-09 公開日 2014-02-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure of a Rare, Non-Standard Sequence K-Turn Bound by L7Ae Protein Nucleic Acids Res., 42, 2014
4CBA	Structural of delta 1-76 CTNNBL1 in space group I222 分子名称: 1,2-ETHANEDIOL, BETA-CATENIN-LIKE PROTEIN 1, SULFATE ION 著者 Ganesh, K, vanMaldegem, F, Telerman, S.B, Simpson, P, Johnson, C.M, Williams, R.L, Neuberger, M.S, Rada, C. 登録日 2013-10-10 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha. Febs Lett., 588, 2014
4C6R	Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPS4 分子名称: DISEASE RESISTANCE PROTEIN RPS4 著者 Williams, S.J, Sohn, K.H, Wan, L, Bernoux, M, Ma, Y, Segonzac, C, Ve, T, Sarris, P, Ericsson, D.J, Saucet, S.B, Zhang, X, Parker, J, Dodds, P.N, Jones, J.D.G, Kobe, B. 登録日 2013-09-19 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor. Science, 344, 2014
4C8B	Structure of the kinase domain of human RIPK2 in complex with ponatinib 分子名称: 1,2-ETHANEDIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 著者 Canning, P, Krojer, T, Bradley, A, Mahajan, P, Goubin, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. 登録日 2013-09-30 公開日 2013-10-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chem. Biol., 22, 2015
5OWC	Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors 分子名称: 3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]propanoic acid, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Sandmark, J.S, Roth, R.G, Knerr, L, Bodin, C, Pettersen, D. 登録日 2017-08-31 公開日 2018-08-01 最終更新日 2021-05-05 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2Type X (sPLA2-X) Inhibitors. Acs Med.Chem.Lett., 9, 2018
4CB9	Structure of full-length CTNNBL1 in P43212 space group 分子名称: BETA-CATENIN-LIKE PROTEIN 1 著者 Ganesh, K, vanMaldegem, F, Telerman, S.B, Simpson, P, Johnson, C.M, Williams, R.L, Neuberger, M.S, Rada, C. 登録日 2013-10-10 公開日 2013-12-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and Mutational Analysis Reveals that Ctnnbl1 Binds Nlss in a Manner Distinct from that of its Closest Armadillo-Relative, Karyopherin Alpha FEBS Lett., 588, 2014

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