4C1I

Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System

Summary for 4C1I

• Entry DOI: 10.2210/pdb4c1i/pdb
• Descriptor: CGMP-DEPENDENT 3', 5'-CYCLIC PHOSPHODIESTERASE, (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol, ZINC ION, ... (5 entities in total)
• Functional Keywords: hydrolase, hydrolase inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform PDE2A3: Cell membrane; Lipid-anchor. Isoform PDE2A2: Mitochondrion matrix. Isoform PDE2A1: Cytoplasm. Isoform 5: Mitochondrion (Probable): O00408
• Total number of polymer chains: 4
• Total formula weight: 167197.82

Authors

Jorgensen, M.,Kehler, J.,Langgard, M.,Svenstrup, N.,Tagmose, L. (deposition date: 2013-08-12, release date: 2014-08-27, Last modification date: 2023-12-20)

• Primary citation: Jorgensen, M.,Kehler, J.,Langgard, M.,Svenstrup, N.,Tagmose, L.; Chapter 4: Selective Inhibitors of Pde2, Pde9, and Pde10: Modulators of Activity of the Central Nervous System; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)