8CXN
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8CXK
| Structure of the C. elegans HIM-3 R93Y mutant | 分子名称: | HORMA domain-containing protein | 著者 | Ego, K.M, Russo, A, Giacopazzi, S, Deshong, A, Menon, M, Ortiz, V, Bhalla, N, Corbett, K.D. | 登録日 | 2022-05-21 | 公開日 | 2023-05-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans. Plos Genet., 19, 2023
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8CXJ
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8CX9
| Structure of the SARS-COV2 PLpro (C111S) in complex with a dimeric Ubv that inhibits activity by an unusual allosteric mechanism | 分子名称: | BROMIDE ION, CHLORIDE ION, Papain-like protease nsp3, ... | 著者 | Singer, A.U, Slater, C.L, Patel, A, Russel, R, Mark, B.L, Sidhu, S.S. | 登録日 | 2022-05-20 | 公開日 | 2023-01-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. Plos Pathog., 18, 2022
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8CX4
| TCR-antigen complex AS8.4-YEIH-HLA*B27 | 分子名称: | AS8.4a, AS8.4b, Beta-2-microglobulin, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-19 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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8CX3
| Crystal structure of full-length mesothelin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Zhan, J, Esser, L, Xia, D. | 登録日 | 2022-05-19 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.609 Å) | 主引用文献 | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3, 2023
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8CWV
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8CWU
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8CWT
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8CWR
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8CWP
| X-ray crystal structure of NTHi Protein D bound to a putative glycerol moiety | 分子名称: | GLYCEROL, Glycerophosphoryl diester phosphodiesterase, SODIUM ION | 著者 | Jones, S.P, Cook, K.H, Holmquist, M.L, Almekinder, L, DeLaney, A, Labbe, N, Perdue, J, Jackson, N, Charles, R, Pichichero, M, Kaur, R, Michel, L, Gleghorn, M.L. | 登録日 | 2022-05-19 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers. Proteins, 91, 2023
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8CWK
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8CWJ
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8CW2
| Crystal structure of TDP1 complexed with compound XZ760 | 分子名称: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-({(4R)-7-phenyl-2-[4-(2-{[4-(pyridin-2-yl)phenyl]methoxy}ethyl)phenyl]imidazo[1,2-a]pyridin-3-yl}amino)benzene-1,2-dicarboxylic acid, ... | 著者 | Lountos, G.T, Zhao, X.Z, Wang, W, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | 登録日 | 2022-05-18 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.811 Å) | 主引用文献 | Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4, 2023
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8CVT
| Human 19S-20S proteasome, state SD2 | 分子名称: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | 著者 | Zhao, J. | 登録日 | 2022-05-18 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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8CVQ
| Crystal structure of TDP1 complexed with compound XZ761 | 分子名称: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}benzene-1,2-dicarboxylic acid, ... | 著者 | Lountos, G.T, Zhao, X.Z, Wang, W, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | 登録日 | 2022-05-18 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4, 2023
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8CVH
| Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | 分子名称: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structure of the L289F H6H cyclization ferryl-mimicking complex To Be Published
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8CVG
| Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | 分子名称: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structure of the L289F H6H cyclization reactant complex To Be Published
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8CVF
| Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.532 Å) | 主引用文献 | Structure of the L289F H6H ferryl-mimicking complex To Be Published
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8CVE
| Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and hyoscyamine | 分子名称: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, FE (II) ION, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Structure of the L289F H6H hydroxylation reactant complex To Be Published
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8CVD
| Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and scopolamine | 分子名称: | (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.717 Å) | 主引用文献 | Structure of the H6H cyclization product complex To Be Published
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8CVC
| Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | 分子名称: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.791 Å) | 主引用文献 | Structure mimicking the H6H cyclization ferryl complex To Be Published
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8CVB
| Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | 分子名称: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.532 Å) | 主引用文献 | Structure of the H6H cyclization reactant complex To Be Published
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8CVA
| Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and 6-OH-hyoscyamine | 分子名称: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.581 Å) | 主引用文献 | Structure of the H6H hydroxylation product complex To Be Published
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8CV9
| Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | 著者 | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | 登録日 | 2022-05-18 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure of the H6H hydroxylation reactant complex To Be Published
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