2ATO
 
 | | Crystal structure of Human Cathepsin K in complex with myocrisin | | 分子名称: | (S)-(1,2-DICARBOXYETHYLTHIO)GOLD, Cathepsin K, SULFATE ION | | 著者 | Weidauer, E, Yasuda, Y, Biswal, B.K, Kerr, L.D, Cherney, M.M, Gordon, R.E, James, M.N.G, Bromme, D. | | 登録日 | 2005-08-25 | | 公開日 | 2006-08-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S.
Biol.Chem., 388, 2007
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7I6O
 | | Group deposition of Coxsackievirus A16 (G-10) 2A protease in complex with inhibitors from the ASAP AViDD centre -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with ASAP-0037765-001 (A71EV2A-x4994) | | 分子名称: | 1-[(1-methyl-1H-indazol-3-yl)acetyl]azetidine-3-carboxamide, DIMETHYL SULFOXIDE, Protease 2A, ... | | 著者 | Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Kenton, N, Tucker, J, DiPoto, M, Lee, A, Fearon, D, von Delft, F. | | 登録日 | 2025-03-12 | | 公開日 | 2025-04-02 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Group deposition of Coxsackievirus A16 (G-10) 2A protease in complex with inhibitors from the ASAP AViDD centre
To Be Published
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4NRN
 | | Crystal structure of metal-bound toxin from Helicobacter pylori | | 分子名称: | ZINC ION, metal-bound toxin | | 著者 | Lee, B.J, Im, H, Pathak, C, Jang, S.B. | | 登録日 | 2013-11-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 angstrom resolution
Protein Sci., 23, 2014
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3KMH
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6TID
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3B6O
 | | Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium) | | 分子名称: | LITHIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1 | | 著者 | Brucet, M, Querol-Audi, J, Fita, I, Celada, A. | | 登録日 | 2007-10-29 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.
Protein Sci., 17, 2008
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7IAB
 | | Group deposition of ZIKV NS2B-NS3 protease in complex with inhibitors from ASAP Discovery Consortium -- Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0029928-001 | | 分子名称: | (2P)-5-chloro-N-(2,3-dihydro-1H-isoindol-5-yl)-2-(1H-1,2,4-triazol-1-yl)benzamide, DIMETHYL SULFOXIDE, Serine protease NS3, ... | | 著者 | Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Chandran, A.V, Walsh, M.A, Fearon, D, von Delft, F. | | 登録日 | 2025-04-10 | | 公開日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (2.152 Å) | | 主引用文献 | Group deposition of ZIKV NS2B-NS3 protease in complex with inhibitors from ASAP Discovery Consortium
To Be Published
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5BZI
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2AXC
 | | Crystal structure of ColE7 translocation domain | | 分子名称: | Colicin E7, GLYCEROL, SULFATE ION | | 著者 | Cheng, Y.S, Shi, Z, Doudeva, L.G, Yang, W.Z, Chak, K.F, Yuan, H.S. | | 登録日 | 2005-09-04 | | 公開日 | 2006-03-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | High-resolution crystal structure of a truncated ColE7 translocation domain: implications for colicin transport across membranes
J.Mol.Biol., 356, 2006
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9D0Z
 | | X-ray crystal structure of H157Q variant Thermothelomyces thermophilus polysaccharide monooxygenase 9E | | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, Glycoside hydrolase family 61 protein, ... | | 著者 | Thomas, W.C, Batka, A.E, Marletta, M.A. | | 登録日 | 2024-08-07 | | 公開日 | 2024-12-04 | | 最終更新日 | 2024-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Second-Sphere Histidine Catalytic Function in a Fungal Polysaccharide Monooxygenase.
Biochemistry, 63, 2024
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2FEF
 | | The Crystal Structure of Protein PA2201 from Pseudomonas aeruginosa | | 分子名称: | 1,2-ETHANEDIOL, hypothetical protein PA2201 | | 著者 | Cymborowski, M.T, Chruszcz, M, Wang, S, Shumilin, I, Kudritska, M, Evdokimova, E, Savchenko, A, Edwards, A.M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2005-12-15 | | 公開日 | 2006-01-31 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Crystal Structure of Protein PA2201 from Pseudomonas aeruginosa
To be Published
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7I9N
 | | Group deposition of ZIKV NS2B-NS3 protease in complex with inhibitors from ASAP Discovery Consortium -- Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0022474-001 | | 分子名称: | (4S)-N-[3-(aminomethyl)phenyl]-2-[(pyrrolidin-1-yl)methyl]imidazo[1,2-a]pyridine-8-carboxamide, DIMETHYL SULFOXIDE, Serine protease NS3, ... | | 著者 | Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Chandran, A.V, Walsh, M.A, Fearon, D, von Delft, F. | | 登録日 | 2025-04-10 | | 公開日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (1.721 Å) | | 主引用文献 | Group deposition of ZIKV NS2B-NS3 protease in complex with inhibitors from ASAP Discovery Consortium
To Be Published
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5C1Y
 | | Crystal structure of EV71 3C Proteinase in complex with Compound 1 | | 分子名称: | 3C proteinase, propan-2-yl N-[(2S)-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-3-phenyl-propan-2-yl]carbamate | | 著者 | Zhang, L, Huang, G, Cai, Q, Zhao, C, Ren, H, Li, P, Li, N, Chen, S, Li, J, Lin, T. | | 登録日 | 2015-06-15 | | 公開日 | 2016-06-01 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
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4NU1
 | | Crystal structure of a transition state mimic of the GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Axin-1, ... | | 著者 | Chu, M.L.-H, Stamos, J.L, Enos, M.D, Shah, N, Weis, W.I. | | 登録日 | 2013-12-03 | | 公開日 | 2014-03-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.
Elife, 3, 2014
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8VCX
 | | Human TCR A2.13 in complex with DQ8-InsCpep | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Tran, T.M, Lim, J.J, Loh, T.J, Mannering, I.S, Rossjohn, J, Reid, H.H. | | 登録日 | 2023-12-14 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8.
J.Biol.Chem., 300, 2024
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3T90
 | | Crystal structure of glucosamine-6-phosphate N-acetyltransferase from Arabidopsis thaliana | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Glucose-6-phosphate acetyltransferase 1, SODIUM ION | | 著者 | Grishkovskaya, I, Herter, T, Riegler, H, Usadel, B. | | 登録日 | 2011-08-02 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure and functional characterization of a glucosamine-6-phosphate N-acetyltransferase from Arabidopsis thaliana.
Biochem.J., 443, 2012
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1NQD
 | | CRYSTAL STRUCTURE OF CLOSTRIDIUM HISTOLYTICUM COLG COLLAGENASE COLLAGEN-BINDING DOMAIN 3B AT 1.65 ANGSTROM RESOLUTION IN PRESENCE OF CALCIUM | | 分子名称: | CALCIUM ION, class 1 collagenase | | 著者 | Wilson, J.J, Matsushita, O, Okabe, A, Sakon, J. | | 登録日 | 2003-01-21 | | 公開日 | 2003-04-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | A Bacterial Collagen-Binding Domain with Novel Calcium-Binding Motif Controls Domain Orientation
Embo J., 22, 2003
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3GCQ
 | | Human P38 MAP kinase in complex with RL45 | | 分子名称: | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | 登録日 | 2009-02-22 | | 公開日 | 2009-06-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
J.Am.Chem.Soc., 131, 2009
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7XTP
 | | eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | | 分子名称: | Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | | 著者 | Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C. | | 登録日 | 2022-05-17 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.828 Å) | | 主引用文献 | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
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3G8V
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2AXE
 | | IODINATED COMPLEX OF ACETYL XYLAN ESTERASE AT 1.80 ANGSTROMS | | 分子名称: | ACETYL XYLAN ESTERASE, SULFATE ION | | 著者 | Ghosh, D, Erman, M, Sawicki, M.W, Lala, P, Weeks, D.R, Li, N, Pangborn, W, Thiel, D.J, Jornvall, H, Eyzaguirre, J. | | 登録日 | 1998-09-01 | | 公開日 | 1999-05-18 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Determination of a protein structure by iodination: the structure of iodinated acetylxylan esterase.
Acta Crystallogr.,Sect.D, 55, 1999
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3G9I
 | | GR DNA Binding domain: Pal complex-35 | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*TP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*AP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*T)-3'), ... | | 著者 | Pufall, M.A, Yamamoto, K.R, Meijsing, S.H. | | 登録日 | 2009-02-13 | | 公開日 | 2009-04-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | DNA binding site sequence directs glucocorticoid receptor structure and activity.
Science, 324, 2009
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2B4Y
 | | Crystal Structure of Human Sirtuin homolog 5 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent deacetylase sirtuin-5, ... | | 著者 | Min, J.R, Antoshenko, T, Dong, A, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2005-09-27 | | 公開日 | 2006-02-28 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of Human Sirtuin homolog 5 in complex with NAD
To be Published
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4QW2
 | | FMRP N-terminal domain (R138Q) | | 分子名称: | 1,2-ETHANEDIOL, Fragile X mental retardation protein 1, LEAD (II) ION | | 著者 | Myrick, L.K, Hashimoto, H, Cheng, X, Warren, S.T. | | 登録日 | 2014-07-16 | | 公開日 | 2014-12-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.989 Å) | | 主引用文献 | Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.
Hum.Mol.Genet., 24, 2015
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5C79
 | | PH domain of ASAP1 in complex with diC4-PtdIns(4,5)P2 | | 分子名称: | (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, Arf-GAP, CHLORIDE ION | | 著者 | Xia, D, Tang, W.K. | | 登録日 | 2015-06-24 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.
Structure, 23, 2015
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