PDB: 82129 件ウェブページステータス検索Chemie searchBIRD

---

8DO3	Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I 分子名称: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.22 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO2	Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) 分子名称: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO1	Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO0	Cryo-EM structure of the human Sec61 complex inhibited by mycolactone 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNZ	Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F 分子名称: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNY	Cryo-EM structure of the human Sec61 complex inhibited by decatransin 分子名称: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNX	Cryo-EM structure of the human Sec61 complex inhibited by cotransin 分子名称: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNW	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2) 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNV	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1) 分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma 著者 Park, E, Itskanov, S. 登録日 2022-07-12 公開日 2023-05-24 最終更新日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNT	SARS-CoV-2 specific T cell receptor 分子名称: Beta-2-microglobulin, MHC class I antigen alpha chain, Nucleoprotein, ... 著者 Gallagher, D.T, Wu, D, Gowthaman, R, Pierce, B.G, Mariuzza, R.A, Weng, N.P. 登録日 2022-07-11 公開日 2023-07-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 SARS-CoV-2 infection establishes a stable and age-independent CD8 + T cell response against a dominant nucleocapsid epitope using restricted T cell receptors. Nat Commun, 14, 2023
8DNQ	BRD2-BD1 in complex with cyclic peptide 2.2B 分子名称: Bromodomain-containing protein 2, Cyclic peptide 2.2B, GLYCEROL 著者 Patel, K, Franck, C, Mackay, J.P. 登録日 2022-07-11 公開日 2023-07-19 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure, 31, 2023
8DNN	Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 80 FAB HEAVY CHAIN, 80 FAB LIGHT CHAIN, ... 著者 Muthuraman, K, Kucharska, I, Ivanochko, D, Julien, J.P. 登録日 2022-07-11 公開日 2023-05-24 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo. Sci Transl Med, 15, 2023
8DNL	Acidipropionibacterium acidipropionici encapsulin in an open state at pH 7.5 分子名称: 29 kDa antigen cfp29 著者 Jones, J.A, Andreas, M.P, Giessen, T.W. 登録日 2022-07-11 公開日 2023-03-22 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Exploring the Extreme Acid Tolerance of a Dynamic Protein Nanocage. Biomacromolecules, 24, 2023
8DNK	Crystal structure of human KRAS G12C covalently bound with Taiho WO2020/085493A1 compound 6 分子名称: 2-{[(5-tert-butyl-6-chloro-1H-indazol-3-yl)amino]methyl}-4-chloro-1-methyl-N-(1-propanoylazetidin-3-yl)-1H-imidazole-5-carboxamide, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... 著者 Mohr, C. 登録日 2022-07-11 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022
8DNJ	Crystal structure of human KRAS G12C covalently bound with AstraZeneca WO2020/178282A1 compound 76 分子名称: 1-[(5S,9P,12aR)-9-(2-chloro-6-hydroxyphenyl)-8-ethynyl-10-fluoro-3,4,12,12a-tetrahydro-6H-pyrazino[2,1-c][1,4]benzoxazepin-2(1H)-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... 著者 Mohr, C. 登録日 2022-07-11 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022
8DNI	Crystal structure of human KRAS G12C covalently bound with Araxes WO2020/028706A1 compound I-1 分子名称: (4P)-4-(5-methyl-1H-indazol-4-yl)-6-(2-propanoyl-2,6-diazaspiro[3.4]octan-6-yl)-2-(pyrrolidin-1-yl)pyrimidine-5-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2022-07-11 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022
8DNA	Acidipropionibacterium acidipropionici encapsulin in a closed state at pH 3.0 分子名称: 29 kDa antigen cfp29 著者 Jones, J.A, Andreas, M.P, Giessen, T.W. 登録日 2022-07-11 公開日 2023-03-22 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Exploring the Extreme Acid Tolerance of a Dynamic Protein Nanocage. Biomacromolecules, 24, 2023
8DN9	Acidipropionibacterium acidipropionici encapsulin in a closed state at pH 7.5 分子名称: 29 kDa antigen cfp29 著者 Jones, J.A, Andreas, M.P, Giessen, T.W. 登録日 2022-07-11 公開日 2023-03-22 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Exploring the Extreme Acid Tolerance of a Dynamic Protein Nanocage. Biomacromolecules, 24, 2023
8DN2	Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state 2(expanded open) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, GLYCINE, ... 著者 Liu, X, Wang, W. 登録日 2022-07-10 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Asymmetric gating of a human hetero-pentameric glycine receptor. Nat Commun, 14, 2023
8DN1	Q108K:K40L:T51C:T53A:R58L:Q38F:Q4F mutant of hCRBPII bound to synthetic fluorophore CM1V at pH 7.2 分子名称: (2E)-3-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]prop-2-enal, bound form, GLYCEROL, ... 著者 Bingham, C.R, Borhan, B, Geiger, J.H. 登録日 2022-07-10 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Light controlled reversible Michael addition of cysteine: a new tool for dynamic site-specific labeling of proteins. Analyst, 148, 2023
8DMD	Room temperature X-ray structure of SARS-CoV-2 main protease in complex with compound ZZ4461624291 分子名称: 1-[(3R)-4-[(3-chlorophenyl)methyl]-3-(2-methylpropyl)piperazin-1-yl]ethan-1-one, 3C-like proteinase 著者 Kovalevsky, A, Coates, L, Kneller, D.W. 登録日 2022-07-08 公開日 2023-05-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 AI-Accelerated Design of Targeted Covalent Inhibitors for SARS-CoV-2. J.Chem.Inf.Model., 63, 2023
8DLE	Crosslinked Crystal Structure of the 8-amino-7-oxonanoate synthase, BioF, and Benzene Sulfonyl Fluoride-crypto Acyl Carrier Protein, BSF-ACP 分子名称: 1,2-ETHANEDIOL, 8-amino-7-oxononanoate synthase, Acyl carrier protein, ... 著者 Chen, A, Davis, T.D, Louie, G.V, Bowman, M.E, Noel, J.P, Burkart, M.D. 登録日 2022-07-07 公開日 2023-07-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crosslinked Crystal Structure of the 8-amino-7-oxonanoate synthase, BioF, and Benzene Sulfonyl Fluoride-crypto Acyl Carrier Protein, BSF-ACP. To Be Published
8DLB	Room temperature X-ray structure of SARS-CoV-2 main protease in complex with compound Z2799209083 分子名称: 1-[(5S)-5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one, 3C-like proteinase 著者 Kovalevsky, A.Y, Coates, L, Kneller, D.W. 登録日 2022-07-07 公開日 2023-05-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 AI-Accelerated Design of Targeted Covalent Inhibitors for SARS-CoV-2. J.Chem.Inf.Model., 63, 2023
8DLA	ClpP2 from Chlamydia trachomatis bound by MAS1-12 分子名称: 1-{4-[(4-chlorophenyl)methyl]piperazin-1-yl}-2-methyl-2-[5-(trifluoromethyl)pyridine-2-sulfonyl]propan-1-one, ATP-dependent Clp protease proteolytic subunit 2, GLYCEROL, ... 著者 Azadmanesh, J, Struble, L.R, Seleem, M.A, Ouellette, S, Conda-Sheridan, M, Borgstahl, G.E.O. 登録日 2022-07-07 公開日 2023-08-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis. J.Biol.Chem., 299, 2023
8DL9	Room temperature X-ray structure of SARS-CoV-2 main protease in complex with compound Z199538122 分子名称: 1-{4-[(naphthalen-1-yl)methyl]piperazin-1-yl}ethan-1-one, 3C-like proteinase 著者 Kovalevsky, A.Y, Coates, L, Kneller, D.W. 登録日 2022-07-07 公開日 2023-05-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 AI-Accelerated Design of Targeted Covalent Inhibitors for SARS-CoV-2. J.Chem.Inf.Model., 63, 2023

<214215216217218219220221222223224225226227228229>