8AO2
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![BU of 8ao2 by Molmil](/molmil-images/mine/8ao2) | Specific covalent inhibitor (3) of ERK2 | 分子名称: | 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... | 著者 | Cleasby, A. | 登録日 | 2022-08-08 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
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8AOD
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![BU of 8aod by Molmil](/molmil-images/mine/8aod) | Specific covalent inhibitor(14) of ERK2 | 分子名称: | 1,2-ETHANEDIOL, 1-(3-oxidanyl-2~{H}-quinoxalin-1-yl)propan-1-one, 4-prop-2-enoyl-1,3-dihydroquinoxalin-2-one, ... | 著者 | Cleasby, A. | 登録日 | 2022-08-08 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
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3OXG
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![BU of 3oxg by Molmil](/molmil-images/mine/3oxg) | human lysine methyltransferase Smyd3 in complex with AdoHcy (Form III) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. | 登録日 | 2010-09-21 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
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8AO7
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![BU of 8ao7 by Molmil](/molmil-images/mine/8ao7) | Specific covalent inhibitor (8) of ERK2 | 分子名称: | 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... | 著者 | Cleasby, A. | 登録日 | 2022-08-08 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
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8AOE
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![BU of 8aoe by Molmil](/molmil-images/mine/8aoe) | Specific covalent inhibitor(15) of ERK2 | 分子名称: | 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... | 著者 | Cleasby, A. | 登録日 | 2022-08-08 | 公開日 | 2022-09-28 | 最終更新日 | 2023-05-24 | 実験手法 | X-RAY DIFFRACTION (1.687 Å) | 主引用文献 | X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
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3OXF
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![BU of 3oxf by Molmil](/molmil-images/mine/3oxf) | Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. | 登録日 | 2010-09-21 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
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6KEA
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![BU of 6kea by Molmil](/molmil-images/mine/6kea) | crystal structure of MBP-tagged REV7-IpaB complex | 分子名称: | Maltose-binding periplasmic protein,LINKER,hREV7,LINKER,Invasin IpaB,hREV3 | 著者 | Wang, X, Pernicone, N, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W. | 登録日 | 2019-07-04 | 公開日 | 2019-09-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch. J.Biol.Chem., 294, 2019
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2C1N
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![BU of 2c1n by Molmil](/molmil-images/mine/2c1n) | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE | 著者 | Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. | 登録日 | 2005-09-16 | 公開日 | 2005-11-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
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6K07
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![BU of 6k07 by Molmil](/molmil-images/mine/6k07) | Crystal structure of REV7(R124A) in complex with a Shieldin3 fragment | 分子名称: | Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 | 著者 | Zhang, F, Dai, Y. | 登録日 | 2019-05-05 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
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2BKA
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![BU of 2bka by Molmil](/molmil-images/mine/2bka) | CC3(TIP30)Crystal Structure | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | El Omari, K, Bird, L.E, Nichols, C.E, Ren, J, Stammers, D.K. | 登録日 | 2005-02-14 | 公開日 | 2005-02-21 | 最終更新日 | 2016-12-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of Cc3 (Tip30): Implications for its Role as a Tumor Suppressor J.Biol.Chem., 280, 2005
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4X2A
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![BU of 4x2a by Molmil](/molmil-images/mine/4x2a) | Crystal structure of mouse glyoxalase I complexed with baicalein | 分子名称: | 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, Lactoylglutathione lyase, ZINC ION | 著者 | Zhang, H, Zhai, J, Zhang, L, Li, C, Zhao, Y, Hu, X. | 登録日 | 2014-11-26 | 公開日 | 2015-09-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | In Vitro Inhibition of Glyoxalase І by Flavonoids: New Insights from Crystallographic Analysis. Curr Top Med Chem, 16, 2016
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7LMS
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4NIF
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![BU of 4nif by Molmil](/molmil-images/mine/4nif) | Heterodimeric structure of ERK2 and RSK1 | 分子名称: | Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1, ... | 著者 | Gogl, G, Remenyi, A. | 登録日 | 2013-11-06 | 公開日 | 2014-11-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex Proc.Natl.Acad.Sci.USA, 112, 2015
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6ULG
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![BU of 6ulg by Molmil](/molmil-images/mine/6ulg) | Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | 分子名称: | Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M. | 登録日 | 2019-10-08 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell, 179, 2019
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2H9P
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![BU of 2h9p by Molmil](/molmil-images/mine/2h9p) | WDR5 in complex with trimethylated H3K4 peptide | 分子名称: | H3 histone, WD-repeat protein 5 | 著者 | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2006-06-10 | 公開日 | 2006-08-01 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
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7RRO
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![BU of 7rro by Molmil](/molmil-images/mine/7rro) | Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia | 分子名称: | Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... | 著者 | Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. | 登録日 | 2021-08-10 | 公開日 | 2021-10-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | De novo identification of mammalian ciliary motility proteins using cryo-EM. Cell, 184, 2021
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7EFA
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6M7A
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1YQM
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![BU of 1yqm by Molmil](/molmil-images/mine/1yqm) | Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA | 分子名称: | 5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*CP*AP*(7GU)P*GP*TP*CP*TP*AP*C)-3', CALCIUM ION, ... | 著者 | Banerjee, A, Yang, W, Karplus, M, Verdine, G.L. | 登録日 | 2005-02-02 | 公開日 | 2005-04-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature, 434, 2005
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6M7B
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2BBY
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![BU of 2bby by Molmil](/molmil-images/mine/2bby) | DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, 30 STRUCTURES | 分子名称: | RAP30 | 著者 | Groft, C.M, Uljon, S.N, Wang, R, Werner, M.H. | 登録日 | 1998-04-27 | 公開日 | 1998-11-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. Proc.Natl.Acad.Sci.USA, 95, 1998
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5IGL
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![BU of 5igl by Molmil](/molmil-images/mine/5igl) | Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine (BSP) | 分子名称: | Bromosporine, Transcription initiation factor TFIID subunit 1-like | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Krojer, T, Tallant, C, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2016-02-28 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv, 2, 2016
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1YQK
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![BU of 1yqk by Molmil](/molmil-images/mine/1yqk) | Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA | 分子名称: | 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*G)-3', 5'-D(P*CP*AP*GP*GP*TP*CP*TP*AP*C)-3', CALCIUM ION, ... | 著者 | Banerjee, A, Yang, W, Karplus, M, Verdine, G.L. | 登録日 | 2005-02-01 | 公開日 | 2005-04-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature, 434, 2005
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1YQR
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![BU of 1yqr by Molmil](/molmil-images/mine/1yqr) | Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxoG containing DNA | 分子名称: | 5'-D(P*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', CALCIUM ION, ... | 著者 | Banerjee, A, Yang, W, Karplus, M, Verdine, G.L. | 登録日 | 2005-02-02 | 公開日 | 2005-04-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature, 434, 2005
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1YQL
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![BU of 1yql by Molmil](/molmil-images/mine/1yql) | Catalytically inactive hOGG1 crosslinked with 7-deaza-8-azaguanine containing DNA | 分子名称: | 5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*CP*AP*(PPW)P*GP*TP*CP*TP*AP*C)-3', CALCIUM ION, ... | 著者 | Banerjee, A, Yang, W, Karplus, M, Verdine, G.L. | 登録日 | 2005-02-02 | 公開日 | 2005-04-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature, 434, 2005
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