7RU0
 
 | | SthK R120A Open State 1 | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | 著者 | Gao, X, Nimigean, C, Schmidpeter, P. | | 登録日 | 2021-08-16 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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7RTJ
 | | SthK Y26F Activated State | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | 著者 | Gao, X, Nimigean, C. | | 登録日 | 2021-08-13 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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7RTF
 | | SthK R120A Closed State | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | 著者 | Gao, X, Nimigean, C. | | 登録日 | 2021-08-13 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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7RSH
 | | SthK Y26F Closed State | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | 著者 | Gao, X, Nimigean, C. | | 登録日 | 2021-08-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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7RQZ
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQY
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQX
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQW
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQV
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQU
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RP0
 | | Structural Snapshots of Intermediates in the Gating of a K+ Channel | | 分子名称: | DIACYL GLYCEROL, KcsA Fab chain A, KcsA Fab chain B, ... | | 著者 | Reddi, R, Matulef, K, Riederer, E.A, Valiyaveetil, F.I. | | 登録日 | 2021-08-02 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structures of Gating Intermediates in a K + channell.
J.Mol.Biol., 433, 2021
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7RK6
 | | Aplysia Slo1 with Barium | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, BARIUM ION, BK channel, ... | | 著者 | Zhu, J, Srivastava, S, Cachau, R, Holmgren, M. | | 登録日 | 2021-07-22 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | CryoEM structure of Aplysia Slo1 with 0 mM Ba2+ at 2.91 A
To Be Published
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7RJT
 | | Aplysia Slo1 with Barium | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, BARIUM ION, BK channel, ... | | 著者 | Zhu, J, Srivastava, S, Cachau, R, Holmgren, M. | | 登録日 | 2021-07-21 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | CryoEM structure of Aplysia Slo1 with 10 mM Ba2+ at 2.93 A
To Be Published
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7RHS
 | | Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cyclic nucleotide-gated cation channel alpha-3, Cyclic nucleotide-gated cation channel beta-3, ... | | 著者 | Zheng, X, Yang, J. | | 登録日 | 2021-07-18 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structure of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 29, 2022
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7RHL
 | | Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil | | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RHK
 | | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state | | 分子名称: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RHJ
 | | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state | | 分子名称: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RHI
 | | Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RHH
 | | Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RHG
 | | Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-17 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RH9
 | | Cryo-EM structure of human rod CNGA1/B1 channel in apo state | | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-07-16 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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7RAU
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7RAS
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7PXH
 | | Emodepside-bound Drosophila Slo channel | | 分子名称: | (3~{S},6~{R},9~{S},12~{R},15~{S},18~{R},21~{S},24~{R})-4,6,10,16,18,22-hexamethyl-3,9,15,21-tetrakis(2-methylpropyl)-12,24-bis[(4-morpholin-4-ylphenyl)methyl]-1,7,13,19-tetraoxa-4,10,16,22-tetrazacyclotetracosane-2,5,8,11,14,17,20,23-octone, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, CALCIUM ION, ... | | 著者 | Raisch, T, Brockmann, A, Ebbinghaus-Kintscher, U, Freigang, J, Gutbrod, O, Kubicek, J, Maertens, B, Hofnagel, O, Raunser, S. | | 登録日 | 2021-10-08 | | 公開日 | 2021-12-15 | | 最終更新日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | | 主引用文献 | Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
Nat Commun, 12, 2021
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7PXG
 | | Verruculogen-bound Drosophila Slo channel | | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, CALCIUM ION, CHOLESTEROL, ... | | 著者 | Raisch, T, Brockmann, A, Ebbinghaus-Kintscher, U, Freigang, J, Gutbrod, O, Kubicek, J, Maertens, B, Hofnagel, O, Raunser, S. | | 登録日 | 2021-10-08 | | 公開日 | 2021-12-15 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
Nat Commun, 12, 2021
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