PDB: 2524 件ウェブページステータス検索Chemie searchBIRD

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8T1I	Atomic model of the mammalian Mediator complex with MED26 subunit 分子名称: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... 著者 Zhao, H, Asturias, F. 登録日 2023-06-02 公開日 2024-06-12 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (4.68 Å) 主引用文献 An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II. Mol.Cell, 84, 2024
8T1L	Atomic model of the mammalian mouse Mediator complex with CKM module 分子名称: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... 著者 Zhao, H, Asturias, F. 登録日 2023-06-02 公開日 2024-07-03 実験手法 ELECTRON MICROSCOPY (4.83 Å) 主引用文献 A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. To Be Published
6YLE	Rix1-Rea1 pre-60S particle - Rix1-subcomplex, body 3 (rigid body refinement) 分子名称: Pre-rRNA-processing protein IPI1, Pre-rRNA-processing protein IPI3, Pre-rRNA-processing protein RIX1 著者 Kater, L, Beckmann, R. 登録日 2020-04-07 公開日 2020-07-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Mol.Cell, 79, 2020
6YLF	Rix1-Rea1 pre-60S particle - Rea1, body 3 (rigid body refinement, composite structure of Rea1 ring and tail) 分子名称: Midasin, Ribosome assembly protein 4 著者 Kater, L, Beckmann, R. 登録日 2020-04-07 公開日 2020-07-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. Mol.Cell, 79, 2020
4GQ2	S. pombe Nup120-Nup37 complex 分子名称: Nucleoporin nup120, Nup37 著者 Liu, X, Mitchell, J, Wozniak, R, Blobel, G, Fan, J. 登録日 2012-08-22 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural evolution of the membrane-coating module of the nuclear pore complex. Proc.Natl.Acad.Sci.USA, 109, 2012
6XBK	Structure of human SMO-G111C/I496C complex with Gi 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Qi, X, Long, T, Li, X. 登録日 2020-06-06 公開日 2020-09-30 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
6XBJ	Structure of human SMO-D384R complex with Gi 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Qi, X, Long, T, Li, X. 登録日 2020-06-06 公開日 2020-09-30 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
6ZG6	COPII on membranes, outer coat vertex 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Zanetti, G, Hutchings, J. 登録日 2020-06-18 公開日 2021-02-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (12 Å) 主引用文献 Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. Nat Commun, 12, 2021
6ZL0	COPII on membranes, outer coat left-handed rod 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Zanetti, G, Hutchings, J. 登録日 2020-06-30 公開日 2021-02-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (40 Å) 主引用文献 Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. Nat Commun, 12, 2021
6ZG5	COPII on membranes, outer coat right-handed rod, class1 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Zanetti, G, Hutchings, J. 登録日 2020-06-18 公開日 2021-02-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (40 Å) 主引用文献 Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. Nat Commun, 12, 2021
4JSN	structure of mTORdeltaN-mLST8 complex 分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT6	structure of mTORDeltaN-mLST8-PI-103 complex 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, mLST8, mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSV	mTOR kinase structure, mechanism and regulation. 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4GGD	Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. 分子名称: Cell division cycle protein 20 homolog, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 著者 Luo, X, Tian, W, Tomchick, D.R. 登録日 2012-08-06 公開日 2012-11-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.435 Å) 主引用文献 Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc.Natl.Acad.Sci.USA, 109, 2012
4G56	Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis 分子名称: Hsl7 protein, MGC81050 protein, S-ADENOSYL-L-HOMOCYSTEINE 著者 Ho, M, Wilczek, C, Bonanno, J, Shechter, D, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2012-07-17 公開日 2012-10-03 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity Plos One, 8, 2013
4JSP	structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT5	mTORdeltaN-mLST8-pp242 complex 分子名称: 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSX	structure of mTORDeltaN-mLST8-Torin2 complex 分子名称: 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
5EMJ	Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin 分子名称: (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol, GLYCEROL, Methylosome protein 50, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.273 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5EML	Crystal structure of PRMT5:MEP50 with Compound 10 and SAM 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5FA5	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ... 著者 Sprague, E.R, McNamara, J.T. 登録日 2015-12-10 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351, 2016
5GXH	The structure of the Gemin5 WD40 domain with AAUUUUUG 分子名称: GLYCEROL, Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*G)-3'), ... 著者 Xu, C, He, H, Li, Y, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2016-09-17 公開日 2016-10-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly Genes Dev., 30, 2016
5GVA	WD40 domain of human AND-1 分子名称: WD repeat and HMG-box DNA-binding protein 1 著者 Guan, C.C, Li, J. 登録日 2016-09-04 公開日 2017-04-19 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome J. Biol. Chem., 292, 2017
5G04	Structure of the human APC-Cdc20-Hsl1 complex 分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... 著者 Zhang, S, Chang, L, Alfieri, C, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. 登録日 2016-03-16 公開日 2016-05-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation. Nature, 533, 2016
5H24	EED in complex with PRC2 allosteric inhibitor compound 8 分子名称: 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H. 登録日 2016-10-14 公開日 2017-01-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem., 60, 2017

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