PDB: 663 件ウェブページステータス検索Chemie searchBIRD

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3S9E	Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate 分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... 著者 Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-06-01 公開日 2011-09-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J.Struct.Biol., 176, 2011
3RTW	Nitrowillardiine bound to the ligand binding domain of GluA2 分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-04 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator 分子名称: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide 著者 Kallen, J. 登録日 2011-03-23 公開日 2011-05-18 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3PMW	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: DIMETHYL SULFOXIDE, GLUTAMIC ACID, GLYCEROL, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2023-05-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMX	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3T9V	CNQX bound to a reduced double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.975 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3T9X	Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.823 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T96	Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.872 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T9H	Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.015 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T93	Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.907 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3TDJ	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution 分子名称: 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, GLUTAMIC ACID, ... 著者 Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-08-11 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
3T9U	CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3UA8	Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2 分子名称: Glutamate receptor 2, N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1H-imidazole-4-carboxamide 著者 Kallen, J. 登録日 2011-10-21 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists. Bioorg.Med.Chem.Lett., 22, 2012
3TKD	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution 分子名称: CYCLOTHIAZIDE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... 著者 Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-08-26 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
6LU9	Rat ionotropic Glutamate Delta-2 receptor in complex with 7-CKA and Calcium 分子名称: Glutamate receptor ionotropic, delta-2 著者 Kumar, J, Burada, A.P. 登録日 2020-01-27 公開日 2020-06-17 最終更新日 2020-12-30 実験手法 ELECTRON MICROSCOPY (8.8 Å) 主引用文献 The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. J.Struct.Biol., 211, 2020
4TLL	Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... 著者 Gouaux, E, Lee, C.-H, Lu, W. 登録日 2014-05-30 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.59 Å) 主引用文献 NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4TLM	Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... 著者 Gouaux, E, Lee, C.-H, Lu, W. 登録日 2014-05-30 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.77 Å) 主引用文献 NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
6MMB	Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-09-30 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (12.7 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMS	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (5.38 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMR	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (5.13 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMV	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.71 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMG	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-09-30 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.23 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018

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