PDB: 890 件ウェブページステータス検索Chemie searchBIRD

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6J1S	Crystal structure of Candida Antarctica Lipase B mutant - SS 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Lipase B, ... 著者 Cen, Y.X, Zhou, J.H, Wu, Q. 登録日 2018-12-29 公開日 2020-01-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters. J.Am.Chem.Soc., 141, 2019
6IZD	Crystal structure of the chromosome-encoded beta-lactamase mutant R168H/M221I of Vibrio parahaemolyticus 分子名称: Beta-lactamase, GLYCEROL 著者 Ma, Q, Li, P. 登録日 2018-12-19 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural analysis of the CARB beta-lactamase from Vibrio parahaemolyticus facilitates application of the beta-lactam/ beta-lactamase inhibitor therapy. Biochimie, 171-172, 2020
6J1T	Crystal structure of Candida Antarctica Lipase B mutant SR with product analogue 分子名称: (2S)-2-phenyl-N-[(1R)-1-phenylethyl]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Cen, Y.X, Zhou, J.H, Wu, Q. 登録日 2018-12-29 公開日 2020-01-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.783 Å) 主引用文献 Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters. J.Am.Chem.Soc., 141, 2019
7PKX	Crystal structure of a DyP-type peroxidase from Bacillus subtilis in P3121 space group 分子名称: Deferrochelatase/peroxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Borges, P.T, Rodrigues, C, Silva, D, Taborda, A, Brissos, V, Frazao, C, Martins, L.O. 登録日 2021-08-27 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.491 Å) 主引用文献 Loops around the Heme Pocket Have a Critical Role in the Function and Stability of Bs DyP from Bacillus subtilis . Int J Mol Sci, 22, 2021
6ISQ	structure of Lipase mutant with oxided Cys-His-Asp catalytic triad 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ISOPROPYL ALCOHOL, ... 著者 Cen, Y.X, Zhou, J.H, Wu, Q. 登録日 2018-11-18 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nat Commun, 10, 2019
6ISR	structure of lipase mutant with Cys-His-Asp catalytic triad 分子名称: DI(HYDROXYETHYL)ETHER, Lipase B, NICKEL (II) ION, ... 著者 Cen, Y.X, Zhou, J.H, Wu, Q. 登録日 2018-11-18 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nat Commun, 10, 2019
2LZE	Ligase 10C 分子名称: ZINC ION, a primordial catalytic fold generated by in vitro evolution 著者 Chao, F, Morelli, A, Haugner, J, Churchfield, L, Hagmann, L, Shi, L, Masterson, L, Sarangi, R, Veglia, G, Seelig, B. 登録日 2012-10-01 公開日 2012-10-24 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure and dynamics of a primordial catalytic fold generated by in vitro evolution. Nat.Chem.Biol., 9, 2013
6TTD	Crystal structure of McoA multicopper oxidase 2F4 variant from the hyperthermophile Aquifex aeolicus 分子名称: COPPER (II) ION, GLYCEROL, Multicopper oxidase, ... 著者 Borges, P.T, Brissos, V, Cordeiro, T.N, Martins, L.O, Frazao, C. 登録日 2019-12-26 公開日 2021-04-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Distal Mutations Shape Substrate-Binding Sites during Evolution of a Metallo-Oxidase into a Laccase Acs Catalysis, 2022
4ITG	P113S mutant of E. coli Cystathionine beta-lyase MetC 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cystathionine beta-lyase MetC 著者 Squire, C.J, Yosaatmadja, Y, Soo, V.W.C, Patrick, W.M. 登録日 2013-01-18 公開日 2014-12-24 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
4ITX	P113S mutant of E. coli Cystathionine beta-lyase MetC inhibited by reaction with L-Ala-P 分子名称: CALCIUM ION, Cystathionine beta-lyase MetC, {1-[(3-HYDROXY-METHYL-5-PHOSPHONOOXY-METHYL-PYRIDIN-4-YLMETHYL)-AMINO]-ETHYL}-PHOSPHONIC ACID 著者 Squire, C.J, Yosaatmadja, Y, Soo, V.W.C, Patrick, W.M. 登録日 2013-01-19 公開日 2014-12-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
6S8V	Structure of the high affinity Anticalin P3D11 in complex with the human CD98 heavy chain ectodomain 分子名称: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin 著者 Schiefner, A, Deuschle, F.-C, Skerra, A. 登録日 2019-07-10 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Development of a high affinity Anticalin®directed against human CD98hc for theranostic applications. Theranostics, 10, 2020
5TOF	Room temperature structure of ubiquitin variant u7ub25 分子名称: Polyubiquitin-B, SULFATE ION 著者 Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. 登録日 2016-10-17 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25, 2017
5TOG	Room temperature structure of ubiquitin variant u7ub25.2540 分子名称: Polyubiquitin-B, SULFATE ION 著者 Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. 登録日 2016-10-17 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.08 Å) 主引用文献 Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25, 2017
8TNR	Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 分子名称: 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
8TNQ	Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 分子名称: 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (2.41 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
8TNP	Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 分子名称: DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... 著者 Roy Burman, S.S, Hunkeler, M, Fischer, E.S. 登録日 2023-08-02 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
4WR3	Y274F alanine racemase from E. coli 分子名称: Alanine racemase, biosynthetic, GLYCEROL, ... 著者 Squire, C.J, Yosaatmadja, Y, Patrick, W.M. 登録日 2014-10-23 公開日 2015-11-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
5AJ9	G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARYLSULFATASE, CALCIUM ION, ... 著者 Miton, C.M, Fischer, G, Jonas, S, Mohammed, M.F, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. 登録日 2015-02-20 公開日 2016-03-16 最終更新日 2019-04-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4XBJ	Y274F alanine racemase from E. coli inhibited by l-ala-p 分子名称: Alanine racemase, biosynthetic, SULFATE ION, ... 著者 Squire, C.J, Yosaatmadja, Y, Patrick, W.M. 登録日 2014-12-17 公開日 2015-12-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
7QLS	CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NADH, AND DIMETHOXYPHENYL ACETAMIDE 分子名称: 2-(3,4-dimethoxyphenyl)ethanamide, ADENOSINE-5-DIPHOSPHORIBOSE, FE (III) ION, ... 著者 Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. 登録日 2021-12-20 公開日 2022-12-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
7QNH	CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NADH, AND GLYCEROL 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE (III) ION, GLYCEROL, ... 著者 Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. 登録日 2021-12-20 公開日 2022-12-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
7QLG	CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT L259V COMPLEXED WITH FE, NADH, AND GLYCEROL 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE (III) ION, GLYCEROL, ... 著者 Sridhar, S, Kiema, T.R, Widertsen, M, Wierenga, R.K. 登録日 2021-12-20 公開日 2022-12-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
7QLQ	CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NAD, AND DIMETHOXYPHENYL ACETAMIDE 分子名称: 2-(3,4-dimethoxyphenyl)ethanamide, ACETATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ... 著者 Sridhar, S, Kiema, T.R, Widersten, M, Wierenga, R.K. 登録日 2021-12-20 公開日 2022-12-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity. Iucrj, 10, 2023
4LRB	Phosphopentomutase S154G variant soaked with 2,3-dideoxyribose 5-phosphate 分子名称: 2,3-dideoxy-5-O-phosphono-alpha-D-ribofuranose, ACETATE ION, GLYCEROL, ... 著者 Birmingham, W.A, Starbird, C.A, Panosian, T.D, Nannemann, D.P, Iverson, T.M, Bachmann, B.O. 登録日 2013-07-19 公開日 2013-07-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nat.Chem.Biol., 10, 2014
6CUN	Engineered Cytochrome c from Rhodothermus marinus (Rma TDE) bound to carbene intermediate (1-ethoxy-1-oxopropan-2-ylidene) 分子名称: Cytochrome c, ETHYL PROPIONATE, HEME C 著者 Lewis, R.D, Buller, A.R, Arnold, F.H. 登録日 2018-03-26 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Catalytic iron-carbene intermediate revealed in a cytochromeccarbene transferase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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