PDB: 243911 件ウェブページステータス検索Chemie searchBIRD

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6DKU	Crystal structure of Myotis VP35 mutant of interferon inhibitory domain 分子名称: VP35 著者 Liu, H, Ginell, G.M, Keefe, L.J, Leung, D.W, Amarasinghe, G.K. 登録日 2018-05-30 公開日 2018-07-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes. Cell Rep, 24, 2018
6DOR	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 300 mM K+ for 120 s at 21 C (dataset 1) 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DI1	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT FRAGMENT LIGAND 分子名称: 4-amino-2-[(3S)-3-(propanoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide, Tyrosine-protein kinase BTK 著者 Jiang, X. 登録日 2018-05-22 公開日 2018-10-17 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk. Bioorg. Med. Chem. Lett., 28, 2018
6DI9	CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT INHIBITOR 分子名称: 6-[(3S)-3-(acryloylamino)pyrrolidin-1-yl]-2-{[4-(tert-butylcarbamoyl)phenyl]amino}pyridine-3-carboxamide, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK 著者 GARDBERG, A. 登録日 2018-05-23 公開日 2018-09-05 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit. Bioorg. Med. Chem. Lett., 28, 2018
6DP4	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 20 mM Mg2+ and 75 mM K+ for 40 s at 21 C 分子名称: 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.374 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DK2	Bacteroidetes AC2a SusD-like 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... 著者 Koropatkin, N.M. 登録日 2018-05-28 公開日 2018-08-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 To Be Published To Be Published
6DLG	Crystal structure of a SHIP1 surface entropy reduction mutant 分子名称: ISOPROPYL ALCOHOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 著者 Gardill, B.R, Cheung, S.T, Mui, A.L, Van Petegem, F. 登録日 2018-06-01 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes Biorxiv, 2020
6DTF	Crystal structure of Haemophilus influenzae OppA complex with KKK 分子名称: LYS-LYS-LYS, Periplasmic oligopeptide-binding protein, SULFATE ION 著者 Tanaka, K.J, Pinkett, H.W. 登録日 2018-06-16 公開日 2018-11-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Oligopeptide-binding protein from nontypeableHaemophilus influenzaehas ligand-specific sites to accommodate peptides and heme in the binding pocket. J. Biol. Chem., 294, 2019
1MHL	CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE ISOFORM C CRYSTALLIZED IN SPACE GROUP P2(1) AT PH 5.5 AND 20 DEG C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Fenna, R.E, Zeng, J, Davey, C. 登録日 1995-06-09 公開日 1996-01-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure of the green heme in myeloperoxidase. Arch.Biochem.Biophys., 316, 1995
2OSX	Endo-glycoceramidase II from Rhodococcus sp.: Ganglioside GM3 Complex 分子名称: Endoglycoceramidase II, GLYCEROL, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... 著者 Caines, M.E.C, Strynadka, N.C.J. 登録日 2007-02-06 公開日 2007-02-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural and Mechanistic Analyses of endo-Glycoceramidase II, a Membrane-associated Family 5 Glycosidase in the Apo and GM3 Ganglioside-bound Forms. J.Biol.Chem., 282, 2007
6DVK	Computationally designed mini tetraloop-tetraloop receptor by the RNAMake program - construct 6 (miniTTR 6) 分子名称: COBALT (II) ION, MAGNESIUM ION, RNA (95-MER) 著者 Eiler, D.R, Yesselman, J.D, Costantino, D.A, Das, R, Kieft, J.S. 登録日 2018-06-24 公開日 2019-06-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Computational design of three-dimensional RNA structure and function. Nat Nanotechnol, 14, 2019
6DVM	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122 分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(dimethylamino)-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-N-{2-[(4-methylphenyl)amino]-2-oxoethyl}benzamide, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2018-06-24 公開日 2018-08-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J. Med. Chem., 61, 2018
6DVO	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with Bavarostat 分子名称: 1,2-ETHANEDIOL, 3-fluoro-N-hydroxy-4-[(methyl{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)methyl]benzamide, Hdac6 protein, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2018-06-24 公開日 2018-08-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J. Med. Chem., 61, 2018
6DON	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 100 mM K+ for 120 s at 21 C (dataset 1) 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.422 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DP1	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 5 mM Mg2+ and 75 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of uncleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of uncleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DPF	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 40 mM Mn2+ and 200 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DWU	Crystal structure of complex of BBKI and Bovine Trypsin 分子名称: Cationic trypsin, Kunitz-type inihibitor 著者 Li, M, Wlodawer, A, Gustchina, A. 登録日 2018-06-28 公開日 2019-01-30 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (3.96 Å) 主引用文献 Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes. Acta Crystallogr D Struct Biol, 75, 2019
6DML	A multiconformer ligand model of 3,5 dimethylisoxaxole bound to the bromodomain of human BRD4 分子名称: 1,2-ETHANEDIOL, 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid, Bromodomain-containing protein 4 著者 Hudson, B.M, van Zundert, G, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H. 登録日 2018-06-05 公開日 2018-12-19 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps. J. Med. Chem., 61, 2018
7S7K	Crystal structure of the EphB2 extracellular domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 2, ... 著者 Xu, Y, Xu, K, Nikolov, D.B. 登録日 2021-09-16 公開日 2021-10-27 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. Int J Mol Sci, 22, 2021
9GEQ	Native dimeric Myeloperoxidase bound to nucleosome core particle; composite map 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Raisch, T, Burn, G.L, Tacke, S, Winkler, M, Prumbaum, D, Thee, S, Zychlinsky, A, Raunser, S. 登録日 2024-08-07 公開日 2025-08-06 最終更新日 2025-10-01 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Nature, 2025
6DMS	Endo-fucoidan hydrolase MfFcnA4_H294Q from glycoside hydrolase family 107 分子名称: 1,2-ETHANEDIOL, Alpha-1,4-endofucoidanase, CALCIUM ION 著者 Vickers, C, Abe, K, Salama-Alber, O, Boraston, A.B. 登録日 2018-06-05 公開日 2018-10-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to alpha-l-fucosidases from GH29. J. Biol. Chem., 293, 2018
6DN2	CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1354 SPLIT RNA 分子名称: 4-{benzyl[2-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl]amino}butanoic acid, MAGNESIUM ION, POTASSIUM ION, ... 著者 Vicens, Q, Mondragon, E, Reyes, F.E, Berman, J, Kaur, H, Kells, K, Wickens, P, Wilson, J, Gadwood, R, Schostarez, H, Suto, R.K, Coish, P, Blount, K.F, Batey, R.T. 登録日 2018-06-05 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem. Biol., 13, 2018
6DVC	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 6nt spacer 分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2018-06-23 公開日 2019-02-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
1MOX	Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Garrett, T.P.J, McKern, N.M, Lou, M, Elleman, T.C, Adams, T.E, Lovrecz, G.O, Zhu, H.-J, Walker, F, Frenkel, M.J, Hoyne, P.A, Jorissen, R.N, Nice, E.C, Burgess, A.W, Ward, C.W. 登録日 2002-09-10 公開日 2003-09-10 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor alpha Cell(Cambridge,Mass.), 110, 2002
6DOC	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 240 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.496 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018

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