PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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5NVW	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(cyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 6) 分子名称: (2~{S},4~{R})-1-[(2~{S})-2-(cyclopropylcarbonylamino)-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. 登録日 2017-05-04 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). J. Med. Chem., 61, 2018
5NVV	pVHL:EloB:EloC in complex with (2S,4R)-4-hydroxy-1-((S)-2-(2-hydroxyacetamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) 分子名称: (2~{S},4~{R})-1-[(2~{S})-3,3-dimethyl-2-(2-oxidanylethanoylamino)butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. 登録日 2017-05-04 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). J. Med. Chem., 61, 2018
4X25	Structural basis for mutation-induced destabilization of Profilin 1 in ALS 分子名称: Profilin-1 著者 Silvas, T.V, Shandilya, S.M.D, Schiffer, C.A. 登録日 2014-11-25 公開日 2015-06-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
4X1L	Structural basis for mutation-induced destabilization of Profilin 1 in ALS 分子名称: PHOSPHATE ION, Profilin-1 著者 Silvas, T.V, Shandilya, S.M.D, Schiffer, C.A. 登録日 2014-11-24 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc.Natl.Acad.Sci.USA, 112, 2015
5NW2	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-3,3-dimethyl-2-(oxetane-3-carboxamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 19) 分子名称: (2~{S},4~{R})-1-[(2~{S})-3,3-dimethyl-2-(oxetan-3-ylcarbonylamino)butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Gadd, M.S, Soares, P, Ciulli, A. 登録日 2017-05-04 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). J. Med. Chem., 61, 2018
4X1M	Structural basis for mutation-induced destabilization of Profilin 1 in ALS 分子名称: Profilin-1 著者 Silvas, T.V, Shandilya, S.M.D, Schiffer, C.A. 登録日 2014-11-24 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
5VHF	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 10, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHH	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 10, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHI	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 10, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
7PER	Model of the inner ring of the human nuclear pore complex 分子名称: Nuclear pore complex protein Nup155, Nuclear pore complex protein Nup205, Nuclear pore complex protein Nup93, ... 著者 Schuller, A.P, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, S.G, Dasso, M, Weis, K, Medalia, O, Schwartz, T.U. 登録日 2021-08-11 公開日 2021-10-20 最終更新日 2021-11-24 実験手法 ELECTRON MICROSCOPY (35 Å) 主引用文献 The cellular environment shapes the nuclear pore complex architecture. Nature, 598, 2021
8E9F	WD repeat-containing protein 5 complexed with 4-(7-((1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-ethyl-N-methylquinoline-8-carboxamide (compound 10) 分子名称: 6-ethyl-4-[(5P)-7-[(1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl]-N-methylquinoline-8-carboxamide, BENZAMIDINE, WD repeat-containing protein 5 著者 Rietz, T.A, Fesik, S.W. 登録日 2022-08-26 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proc.Natl.Acad.Sci.USA, 120, 2023
8GQ6	Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex 分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... 著者 Sun, L, Chen, Z, Hu, Y, Mao, Q. 登録日 2022-08-29 公開日 2023-09-06 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.96 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
5DLQ	Crystal structure of RanGTP-Exportin 4-eIF5A complex 分子名称: Eukaryotic translation initiation factor 5A-1, Exportin-4, GTP-binding nuclear protein Ran, ... 著者 Aksu, M, Trakhanov, S, Gorlich, D. 登録日 2015-09-07 公開日 2016-06-22 最終更新日 2016-06-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun, 7, 2016
8F1G	Crystal structure of human WDR5 in complex with compound WM662 分子名称: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... 著者 Liu, H. 登録日 2022-11-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
6ZRB	Crystal structure of SMYD3 conjugate with piperidine-based covalent inhibitor EM127 分子名称: ACETATE ION, Histone-lysine N-methyltransferase SMYD3, N-[1-(2-Chloroacetyl)piperidin-4-yl]-5-cyclopropyl-1,2-oxazole-3-carboxamide, ... 著者 Talibov, V.O, Eriksson, D. 登録日 2020-07-13 公開日 2022-07-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3 Eur.J.Med.Chem., 2022
5FXY	Structure of the human RBBP4:MTA1(464-546) complex 分子名称: HISTONE-BINDING PROTEIN RBBP4, METASTASIS-ASSOCIATED PROTEIN MTA1 著者 Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R. 登録日 2016-03-03 公開日 2016-05-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife, 5, 2016
5NVX	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 10) 分子名称: Elongin-B, Elongin-C, N-[(1-fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, Ciulli, A. 登録日 2017-05-04 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). J. Med. Chem., 61, 2018
5O90	Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide. 分子名称: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 著者 Nichols, C.E, De Nicola, G.F, Thapa, D. 登録日 2017-06-15 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 TAB1-Induced Autoactivation of p38 alpha Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Mol. Cell. Biol., 38, 2018
7W3H	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W39	Structure of USP14-bound human 26S proteasome in state EA2.1_UBL 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3J	Structure of USP14-bound human 26S proteasome in substrate-inhibited state SC_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3B	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3A	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3G	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.0_USP14 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W37	Structure of USP14-bound human 26S proteasome in state EA1_UBL 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. 登録日 2021-11-25 公開日 2022-05-04 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022

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