PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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5XY9	Structure of the MST4 and 14-3-3 complex 分子名称: 14-3-3 protein zeta/delta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, GLYCEROL, ... 著者 Shi, Z.B, Zhou, Z.C. 登録日 2017-07-06 公開日 2018-07-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 Structure of the MST4 and 14-3-3 complex To Be Published
7NMZ	Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448 分子名称: 14-3-3 protein eta, E3 ubiquitin-protein ligase NEDD4-like 著者 Pohl, P, Obsil, T, Obsilova, V. 登録日 2021-02-23 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
7PWT	Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptor alpha phosphopeptide, stabilised by pyrrolidone derivative 228 分子名称: (2~{R})-1-(2-hydroxyphenyl)-2-(4-nitrophenyl)-4-oxidanyl-3-(phenylcarbonyl)-2~{H}-pyrrol-5-one, 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, ... 著者 Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. 登録日 2021-10-07 公開日 2022-12-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.312 Å) 主引用文献 Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
7ORT	Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ176 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-06 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
5JM4	Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GLN-GLY-MKD-ANG-ASP-MKD-LEU-ASP-LEU-ALA-CLU 著者 Bier, D, Krueger, D, Glas, A, Wallraven, K, Ottmann, C, Hennig, S, Grossmann, T. 登録日 2016-04-28 公開日 2017-05-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions. J. Med. Chem., 60, 2017
6GN8	Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 14-3-3 protein beta/alpha, Exoenzyme S 著者 Karlberg, T, Pinto, A.F, Hornyak, P, Thorsell, A.G, Nareoja, K, Schuler, H. 登録日 2018-05-30 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface. Nat Commun, 9, 2018
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 著者 Bier, D, Ottmann, C. 登録日 2015-11-23 公開日 2016-05-04 最終更新日 2018-12-19 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. 分子名称: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-13 公開日 2023-11-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
6BD1	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366 分子名称: 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, Insulin receptor substrate protein of 53 kDa, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
5M37	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface 分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... 著者 Bier, D, Ottmann, C. 登録日 2016-10-14 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
5NWI	14-3-3c in complex with CPP 分子名称: 14-3-3 c-1 protein, ACETATE ION, Potassium channel KAT1 著者 Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. 登録日 2017-05-06 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
5OK9	CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with swapped phosphopeptides 分子名称: 14-3-3 protein sigma,Heat shock protein beta-6, DI(HYDROXYETHYL)ETHER 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-25 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
5OEH	Molecular tweezers modulate 14-3-3 protein-protein interactions. 分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Bier, D, Ottmann, C. 登録日 2017-07-07 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem, 5, 2013
5F74	Crystal structure of ChREBP:14-3-3 complex bound with AMP 分子名称: 14-3-3 protein beta/alpha, ADENOSINE MONOPHOSPHATE, Carbohydrate-responsive element-binding protein 著者 Jung, H, Uyeda, K. 登録日 2015-12-07 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J.Biol.Chem., 291, 2016
7Q16	Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74 分子名称: 14-3-3 protein zeta/delta,Bcl2-associated agonist of cell death 著者 Sluchanko, N.N, Tugaeva, K.V, Gushchin, I, Remeeva, A, Kovalev, K, Cooley, R.B. 登録日 2021-10-18 公開日 2021-11-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.356 Å) 主引用文献 Crystal structure of human 14-3-3 zeta complexed with the noncanonical phosphopeptide from proapoptotic BAD. Biochem.Biophys.Res.Commun., 583, 2021
5M35	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GLYCEROL, ... 著者 Bier, D, Ottmann, C. 登録日 2016-10-14 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
6EJL	Structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif 分子名称: 14-3-3 protein zeta/delta, Mitogen-activated protein kinase kinase kinase 5 著者 Petrvalska, O, Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2017-09-21 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.382 Å) 主引用文献 Crystal structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif To Be Published
3RDH	X-ray induced covalent inhibition of 14-3-3 分子名称: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION 著者 Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. 登録日 2011-04-01 公開日 2011-09-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
5J31	Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, Exoenzyme S 著者 Wallraven, K, Cromm, P, Bier, D, Glas, A, Grossmann, T. 登録日 2016-03-30 公開日 2016-10-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis. Chembiochem, 17, 2016
1YWT	Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) 著者 Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. 登録日 2005-02-18 公開日 2005-03-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A structural basis for 14-3-3sigma functional specificity. J.Biol.Chem., 280, 2005
6TLG	Ligand-free state of human 14-3-3 sigma isoform 分子名称: 14-3-3 protein sigma, DI(HYDROXYETHYL)ETHER, SULFATE ION 著者 Tassone, G, Pozzi, C, Mangani, S. 登録日 2019-12-02 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
3CU8	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... 著者 Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. 登録日 2008-04-16 公開日 2009-05-05 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
5LU1	Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide 分子名称: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heat shock protein beta-6 著者 Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. 登録日 2016-09-07 公開日 2017-02-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase 著者 Schumacher, B, Weyand, M, Ottmann, C. 登録日 2010-06-21 公開日 2010-09-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
3AXY	Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1 分子名称: 14-3-3-like protein GF14-C, Protein HEADING DATE 3A, Rice FD homolog OsFD1 著者 Ohki, I, Furuita, K, Hayashi, K, Taoka, K, Tsuji, H, Nakagawa, A, Shimamoto, K, Kojima, C. 登録日 2011-04-19 公開日 2011-08-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen Nature, 476, 2011

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