PDB: 105 件ウェブページステータス検索Chemie searchBIRD

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7WVA	Crystal structure of mouse Cryptochrome 1 in complex with TH401 compound 分子名称: 2-(1-methylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2,3,4-trimethoxyphenyl)methylideneamino]ethanamide, Cryptochrome-1 著者 Miller, S.A, Hirota, T. 登録日 2022-02-10 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. F1000Res, 11, 2022
1NP7	Crystal Structure Analysis of Synechocystis sp. PCC6803 cryptochrome 分子名称: DNA photolyase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION 著者 Brudler, R, Hitomi, K, Daiyasu, H, Toh, H, Kucho, K, Ishiura, M, Kanehisa, M, Roberts, V.A, Todo, T, Tainer, J.A, Getzoff, E.D. 登録日 2003-01-17 公開日 2003-01-28 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of a new cryptochrome class: structure, function, and evolution Mol.Cell, 11, 2003
4MLP	Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase 分子名称: Cryptochrome-2, N-[(2S)-3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(furan-2-ylmethyl)methanesulfonamide 著者 Nangle, S, Xing, W, Zheng, N. 登録日 2013-09-06 公開日 2013-10-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.943 Å) 主引用文献 Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res., 23, 2013
8P4X	FAD_ox bound dark state structure of PdLCry 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, Putative light-receptive cryptochrome (Fragment) 著者 Behrmann, E, Behrmann, H. 登録日 2023-05-23 公開日 2023-11-08 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 A marine cryptochrome with an inverse photo-oligomerization mechanism. Nat Commun, 14, 2023
4GU5	Structure of Full-length Drosophila Cryptochrome 分子名称: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION 著者 Zoltowski, B.D, Vaidya, A.T, Top, D, Widom, J, Young, M.W, Levy, C, Jones, A.R, Scrutton, N.S, Leys, D, Crane, B.R. 登録日 2012-08-29 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Updated structure of Drosophila cryptochrome. Nature, 495, 2013
4K03	Crystal structure of Drosophila Cryprochrome 分子名称: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE 著者 Berndt, A, Wolf, E. 登録日 2013-04-03 公開日 2013-06-26 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell(Cambridge,Mass.), 153, 2013
6OF7	Crystal structure of the CRY1-PER2 complex 分子名称: Cryptochrome-1, Period circadian protein homolog 2 著者 Michael, A.K, Fribourgh, J.L, Tripathi, S.M, Partch, C.L. 登録日 2019-03-28 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Elife, 9, 2020
4I6J	A ubiquitin ligase-substrate complex 分子名称: Cryptochrome-2, F-box/LRR-repeat protein 3, S-phase kinase-associated protein 1 著者 Xing, W, Busino, L, Hinds, T.R, Marionni, S.T, Saifee, N.H, Bush, M.F, Pagano, M, Zheng, N. 登録日 2012-11-29 公開日 2013-03-13 最終更新日 2013-05-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature, 496, 2013
6K8K	Crystal structure of Arabidopsis thaliana BIC2-CRY2 complex 分子名称: ADENOSINE MONOPHOSPHATE, Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Wang, X, Ma, L, Guan, Z, Yin, P. 登録日 2019-06-12 公開日 2020-05-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat.Struct.Mol.Biol., 27, 2020
6KX4	Crystal structure of mouse Cryptochrome 1 apo form 分子名称: Cryptochrome-1 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX6	Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound 分子名称: Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX5	Crystal structure of mouse Cryptochrome 1 in complex with KL044 compound 分子名称: 2-carbazol-9-yl-N-(2-chloranyl-6-cyano-phenyl)ethanamide, Cryptochrome-1 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX8	Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound 分子名称: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
6KX7	Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound 分子名称: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2019-09-10 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
5T5X	High resolution structure of mouse Cryptochrome 1 分子名称: CHLORIDE ION, Cryptochrome-1 著者 Michael, A.K, Tripathi, S, Partch, C.L. 登録日 2016-08-31 公開日 2017-02-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XMZ	Verticillium effector PevD1 分子名称: CALCIUM ION, CHLORIDE ION, Effector protein PevD1 著者 Liu, X, Zhou, R. 登録日 2017-05-17 公開日 2017-07-05 最終更新日 2017-09-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2 J. Exp. Bot., 68, 2017
3FY4	(6-4) Photolyase Crystal Structure 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-4 photolyase, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Hitomi, K, Arvai, A.S, Tainer, J.A, Getzoff, E.D. 登録日 2009-01-21 公開日 2009-04-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc.Natl.Acad.Sci.USA, 106, 2009
4CT0	Crystal Structure of Mouse Cryptochrome1 in Complex with Period2 分子名称: CHLORIDE ION, CRYPTOCHROME-1, HEXAETHYLENE GLYCOL, ... 著者 Schmalen, I, Rajan Prabu, J, Benda, C, Wolf, E. 登録日 2014-03-11 公開日 2014-06-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Interaction of Circadian Clock Proteins Cry1 and Per2 is Modulated by Zinc Binding and Disulfide Bond Formation. Cell(Cambridge,Mass.), 157, 2014
7EJ9	Alternative crystal structure of mouse Cryptochrome 2 in complex with TH301 compound 分子名称: 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 著者 Miller, S.A, Hirota, T. 登録日 2021-04-01 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
7QUT	serial synchrotron crystallographic structure of Drosophila Melanogaster (6-4) photolyase 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, RE11660p 著者 Cellini, A, Weixiao, Y.W, Kumar, M.S, Westenhoff, S. 登録日 2022-01-18 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structural basis of the radical pair state in photolyases and cryptochromes. Chem.Commun.(Camb.), 58, 2022
7D0N	Crystal structure of mouse CRY2 apo form 分子名称: Cryptochrome-2 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2020-09-11 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
7D0M	Crystal structure of mouse CRY1 with bound cryoprotectant 分子名称: Cryptochrome-1, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2020-09-11 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
7D1C	Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 分子名称: Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide 著者 Miller, S.A, Hirota, T. 登録日 2020-09-14 公開日 2021-01-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
7D19	Crystal structure of mouse Cryptochrome 1 in complex with compound TH129 分子名称: Cryptochrome-1, N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide 著者 Miller, S.A, Hirota, T. 登録日 2020-09-14 公開日 2021-01-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
7DLI	Crystal structure of mouse CRY1 in complex with KL001 compound 分子名称: 1,2-ETHANEDIOL, Cryptochrome-1, N-[(2R)-3-carbazol-9-yl-2-oxidanyl-propyl]-N-(furan-2-ylmethyl)methanesulfonamide 著者 Miller, S.A, Aikawa, Y, Hirota, T. 登録日 2020-11-27 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021

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