PDB: 214 件ウェブページステータス検索Chemie searchBIRD

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1NWC	Crystal Structure of Aspartate-Semialdehyde Dehydrogenase from Haemophilus influenzae 分子名称: Aspartate-semialdehyde dehydrogenase 著者 Blanco, J, Moore, R.A, Viola, R.E. 登録日 2003-02-05 公開日 2003-11-04 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Capture of an Intermediate in the Catalytic Cycle of L-Aspartate-beta-Semialdehyde Dehydrogenase Proc.Natl.Acad.Sci.USA, 100, 2003
1MC4	Crystal Structure of Aspartate-Semialdehyde dehydrogenase from Vibrio Cholerae El Tor 分子名称: Aspartate-semialdehyde dehydrogenase 著者 Blanco, J, Moore, R.A, Kabaleeswaran, V, Viola, R.E. 登録日 2002-08-05 公開日 2003-03-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 A Structural Basis for the Mechanism of Aspartate-beta-semialdehyde Dehydrogenase from Vibrio Cholerae Protein Sci., 12, 2003
2GYY	Structure of aspartate semialdehyde dehydrogenase (ASADH) from Streptococcus pneumoniae 分子名称: Aspartate beta-semialdehyde dehydrogenase 著者 Faehnle, C.R, Le Coq, J, Liu, X, Viola, R.E. 登録日 2006-05-10 公開日 2006-08-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria. J.Biol.Chem., 281, 2006
1OZA	Crystal Structure of the R103L Mutant of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae 分子名称: Aspartate-semialdehyde dehydrogenase 著者 Blanco, J, Moore, R.A, Viola, R.E. 登録日 2003-04-08 公開日 2004-06-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallogr.,Sect.D, 60, 2004
1NX6	Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithiocetal Reaction intermediate with Phosphate at 2.15 A 分子名称: Aspartate-Semialdehyde Dehydrogenase, PHOSPHATE ION 著者 Blanco, J, Moore, R.A, Viola, R.E. 登録日 2003-02-09 公開日 2003-11-04 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Capture of an Intermediate in the Catalytic Cycle of L-Aspartate-beta-Semialdehyde Dehydrogenase Proc.Natl.Acad.Sci.USA, 100, 2003
1NWH	Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A 分子名称: Aspartate-semialdehyde dehydrogenase 著者 Blanco, J, Moore, R.A, Viola, R.E. 登録日 2003-02-06 公開日 2003-11-04 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Capture of an Intermediate in the Catalytic Cycle of L-Aspartate-beta-Semialdehyde Dehydrogenase Proc.Natl.Acad.Sci.USA, 100, 2003
1YS4	Structure of Aspartate-Semialdehyde Dehydrogenase from Methanococcus jannaschii 分子名称: Aspartate-semialdehyde dehydrogenase, MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Faehnle, C.R, Ohren, J.F, Viola, R.E. 登録日 2005-02-07 公開日 2005-11-01 最終更新日 2015-04-29 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 A New Branch in the Family: Structure of Aspartate-beta-semialdehyde Dehydrogenase from Methanococcus jannaschii J.Mol.Biol., 353, 2005
6ZNV	Protein polybromo-1 (PB1 BD2) Bound To DP28 分子名称: 1,2-ETHANEDIOL, 1-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperidin-4-ol, ACETATE ION, ... 著者 Preuss, F, Mathea, S, Chatterjee, D, Wanior, M, Joerger, A.C, Knapp, S. 登録日 2020-07-06 公開日 2020-08-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63, 2020
6ZS4	Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate 分子名称: 1,2-ETHANEDIOL, Protein polybromo-1, tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate 著者 Preuss, F, Joerger, A.C, Kraemer, A, Wanior, M, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-07-15 公開日 2020-10-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63, 2020
6ZN6	Protein polybromo-1 (PB1 BD2) Bound To MW278 分子名称: 1,2-ETHANEDIOL, 2-[6-azanyl-5-[(3~{R})-3-phenoxypiperidin-1-yl]pyridazin-3-yl]phenol, Protein polybromo-1 著者 Preuss, F, Mathea, S, Chatterjee, D, Wanior, M, Joerger, A.C, Knapp, S. 登録日 2020-07-06 公開日 2020-08-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63, 2020
6ZS3	Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol 分子名称: 1,2-ETHANEDIOL, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, Protein polybromo-1 著者 Preuss, F, Joerger, A.C, Wanior, M, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-07-15 公開日 2020-10-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63, 2020
6HAZ	Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand 分子名称: 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, Probable global transcription activator SNF2L2, ZINC ION 著者 Bader, G, Steurer, S, Weiss-Puxbaum, A, Zoephel, A, Roy, M, Ciulli, A. 登録日 2018-08-09 公開日 2019-06-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
6HAY	Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB 分子名称: (2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. 登録日 2018-08-09 公開日 2019-06-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
6HAX	Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB 分子名称: (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. 登録日 2018-08-09 公開日 2019-06-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
7VDV	The overall structure of human chromatin remodeling PBAF-nucleosome complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2, Actin, ... 著者 Chen, Z.C, Chen, K.J, Yuan, J.J. 登録日 2021-09-07 公開日 2022-05-18 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. Nature, 605, 2022
6OXB	First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) 分子名称: CHLORIDE ION, Protein polybromo-1, SULFATE ION 著者 Petojevic, T, Holliday, M.J, Fairbrother, W.J, Cochran, A.G. 登録日 2019-05-13 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Polyvalent nucleosome recognition by Polybromo-1 anchors chromatin remodeling To Be Published
6KO2	Crystal Structure of BRD4-Brmo2 in complex with H2A.ZK4acK7ac peptide 分子名称: Bromodomain-containing protein 4, histone H2A.Z peptide 著者 Li, H.T, Zheng, S.P. 登録日 2019-08-07 公開日 2020-08-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal Structure of BRD4-Bromo2 in complex with H2A.ZK4acK7ac peptide To be published
1MB4	Crystal structure of aspartate semialdehyde dehydrogenase from vibrio cholerae with NADP and S-methyl-l-cysteine sulfoxide 分子名称: Aspartate-Semialdehyde Dehydrogenase, CYSTEINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Blanco, J, Moore, R.A, Kabaleeswaran, V, Viola, R.E. 登録日 2002-08-02 公開日 2003-01-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 A structural Basis for the Mechanism of Aspartate-beta-semialdehyde Dehydrogenase from Vibrio Cholerae Protein Sci., 12, 2003
2R21	Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.6 A (BrMn) 分子名称: MANGANESE (II) ION, RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3'), SODIUM ION 著者 Timsit, Y, Bombard, S. 登録日 2007-08-24 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 1.3 A resolution Structure of the tridecamer r(GCGUUUGAAACGC) TO BE PUBLISHED
3AGF	Crystal structure of Bacillus glutaminase in the presence of 4.3M NaCl 分子名称: Glutaminase 1 著者 Yoshimune, K, Shirakihara, Y, Yumoto, I. 登録日 2010-03-30 公開日 2011-04-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Salt-induced conformational change of salt-tolerant glutaminase from Micrococcus luteus K-3 To be Published
2CGV	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening 分子名称: (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Foloppe, N, Fisher, L.M, Howes, R, Potter, A, Robertson, A.G.S, Surgenor, A.E. 登録日 2006-03-09 公開日 2006-04-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of Chemically Diverse Chk1 Inhibitors by Receptor-Based Virtual Screening. Bioorg.Med.Chem., 14, 2006
2CGU	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening 分子名称: 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Foloppe, N, Fisher, L.M, Howes, R, Potter, A, Robertson, A.G.S, Surgenor, A.E. 登録日 2006-03-09 公開日 2006-04-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification of Chemically Diverse Chk1 Inhibitors by Receptor-Based Virtual Screening. Bioorg.Med.Chem., 14, 2006
2CGW	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening 分子名称: 4,4'-(1-PROPYL-1H-1,2,4-TRIAZOLE-3,5-DIYL)BIS(2,5-DIHYDRO-1,2,5-OXADIAZOL-3-AMINE), SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Foloppe, N, Fisher, L.M, Howes, R, Potter, A, Robertson, A.G.S, Surgenor, A.E. 登録日 2006-03-09 公開日 2006-04-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of Chemically Diverse Chk1 Inhibitors by Receptor-Based Virtual Screening. Bioorg.Med.Chem., 14, 2006
2CGX	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening 分子名称: 2-[(6-AMINO-7H-PURIN-8-YL)THIO]ACETAMIDE, SERINE/THREONINE-PROTEIN KINASE CHK1 著者 Foloppe, N, Fisher, L.M, Howes, R, Potter, A, Robertson, A.G.S, Surgenor, A.E. 登録日 2006-03-09 公開日 2006-04-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of Chemically Diverse Chk1 Inhibitors by Receptor-Based Virtual Screening. Bioorg.Med.Chem., 14, 2006
2BR1	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 分子名称: 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION 著者 Foloppe, N, Fisher, L.M, Howes, R, Kierstan, P, Potter, A, Robertson, A.G.S, Surgenor, A.E. 登録日 2005-04-29 公開日 2005-05-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity. J.Med.Chem., 48, 2005

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