6ZS3

Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol

Summary for 6ZS3

Entry DOI	10.2210/pdb6zs3/pdb
Descriptor	Protein polybromo-1, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain, complex, small molecule, structural genomics consortium, sgc, transcription, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29964.79
Authors	Preuss, F.,Joerger, A.C.,Wanior, M.,Kraemer, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-07-15, release date: 2020-10-07, Last modification date: 2024-01-31)
Primary citation	Wanior, M.,Preuss, F.,Ni, X.,Kramer, A.,Mathea, S.,Gobel, T.,Heidenreich, D.,Simonyi, S.,Kahnt, A.S.,Joerger, A.C.,Knapp, S. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63:14680-14699, 2020 Cited by PubMed: 33216538 DOI: 10.1021/acs.jmedchem.0c01242 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation