6ZS3
Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue FX5 A 801 |
| Chain | Residue |
| A | ILE683 |
| A | ILE745 |
| A | HOH901 |
| A | HOH976 |
| B | HOH935 |
| A | PHE684 |
| A | LEU687 |
| A | LEU693 |
| A | TYR696 |
| A | MET704 |
| A | ALA735 |
| A | TYR738 |
| A | ASN739 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 802 |
| Chain | Residue |
| A | ARG690 |
| A | TYR697 |
| A | PHE732 |
| A | ASN733 |
| A | CYS736 |
| A | LEU750 |
| A | HIS753 |
| A | HOH908 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 803 |
| Chain | Residue |
| A | ALA682 |
| A | ILE683 |
| A | LEU685 |
| A | ARG686 |
| A | HOH970 |
| B | ILE745 |
| B | HOH917 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue FX5 B 801 |
| Chain | Residue |
| A | HOH917 |
| B | ILE683 |
| B | PHE684 |
| B | LEU687 |
| B | TYR696 |
| B | MET704 |
| B | ALA735 |
| B | TYR738 |
| B | ASN739 |
| B | ILE745 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY |
| Chain | Residue | Details |
| A | SER681-TYR738 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
