6ZN6

Protein polybromo-1 (PB1 BD2) Bound To MW278

Summary for 6ZN6

Entry DOI	10.2210/pdb6zn6/pdb
Descriptor	Protein polybromo-1, 2-[6-azanyl-5-[(3~{R})-3-phenoxypiperidin-1-yl]pyridazin-3-yl]phenol, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain inhibitor epigenetics, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	27249.52
Authors	Preuss, F.,Mathea, S.,Chatterjee, D.,Wanior, M.,Joerger, A.C.,Knapp, S. (deposition date: 2020-07-06, release date: 2020-08-26, Last modification date: 2024-01-31)
Primary citation	Wanior, M.,Preuss, F.,Ni, X.,Kramer, A.,Mathea, S.,Gobel, T.,Heidenreich, D.,Simonyi, S.,Kahnt, A.S.,Joerger, A.C.,Knapp, S. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63:14680-14699, 2020 Cited by PubMed: 33216538 DOI: 10.1021/acs.jmedchem.0c01242 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation