6HAZ

Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand

Summary for 6HAZ

• Entry DOI: 10.2210/pdb6haz/pdb
• Descriptor: Probable global transcription activator SNF2L2, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, ZINC ION, ... (4 entities in total)
• Functional Keywords: bromodomain, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29436.55

Authors

Bader, G.,Steurer, S.,Weiss-Puxbaum, A.,Zoephel, A.,Roy, M.,Ciulli, A. (deposition date: 2018-08-09, release date: 2019-06-12, Last modification date: 2024-01-17)

• Primary citation: Farnaby, W.,Koegl, M.,Roy, M.J.,Whitworth, C.,Diers, E.,Trainor, N.,Zollman, D.,Steurer, S.,Karolyi-Oezguer, J.,Riedmueller, C.,Gmaschitz, T.,Wachter, J.,Dank, C.,Galant, M.,Sharps, B.,Rumpel, K.,Traxler, E.,Gerstberger, T.,Schnitzer, R.,Petermann, O.,Greb, P.,Weinstabl, H.,Bader, G.,Zoephel, A.,Weiss-Puxbaum, A.,Ehrenhofer-Wolfer, K.,Wohrle, S.,Boehmelt, G.,Rinnenthal, J.,Arnhof, H.,Wiechens, N.,Wu, M.Y.,Owen-Hughes, T.,Ettmayer, P.,Pearson, M.,McConnell, D.B.,Ciulli, A.; BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.; Nat.Chem.Biol., 15:672-680, 2019; PubMed: 31178587; DOI: 10.1038/s41589-019-0294-6

Experimental method

X-RAY DIFFRACTION (1.31 Å)