7FD5
| A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. | 登録日 | 2021-07-16 | 公開日 | 2021-11-03 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
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7FID
| Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | 登録日 | 2021-07-31 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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6WZV
| Lon protease proteolytic domain | 分子名称: | Lon protease homolog, mitochondrial, N-[(1R)-1-borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide, ... | 著者 | Lee, C.C, Spraggon, G. | 登録日 | 2020-05-14 | 公開日 | 2021-04-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology. J.Med.Chem., 64, 2021
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7P09
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7P0M
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8OJL
| Human Mitochondrial Lon Y394E Mutant ADP Bound | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. | 登録日 | 2023-03-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
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6ON2
| Lon Protease from Yersinia pestis with Y2853 substrate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ... | 著者 | Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | 登録日 | 2019-04-19 | 公開日 | 2019-05-01 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
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1Z0V
| Crystal Structure of A. fulgidus Lon proteolytic domain | 分子名称: | Putative protease La homolog type | 著者 | Dauter, Z, Botos, I, LaRonde-LeBlanc, N, Wlodawer, A. | 登録日 | 2005-03-02 | 公開日 | 2005-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Pathological crystallography: case studies of several unusual macromolecular crystals. Acta Crystallogr.,Sect.D, 61, 2005
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1Z0T
| Crystal Structure of A. fulgidus Lon proteolytic domain | 分子名称: | Putative protease La homolog type | 著者 | Dauter, Z, Botos, I, LaRonde-LeBlanc, N, Wlodawer, A. | 登録日 | 2005-03-02 | 公開日 | 2005-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Pathological crystallography: case studies of several unusual macromolecular crystals. Acta Crystallogr.,Sect.D, 61, 2005
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5E7S
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7KSM
| Human mitochondrial LONP1 with endogenous substrate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | 著者 | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | 登録日 | 2020-11-23 | 公開日 | 2020-12-02 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7KRZ
| Human mitochondrial LONP1 in complex with Bortezomib | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... | 著者 | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | 登録日 | 2020-11-20 | 公開日 | 2021-02-24 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7FIZ
| Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | 登録日 | 2021-08-01 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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7SXO
| Yeast Lon (PIM1) with endogenous substrate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | 著者 | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | 登録日 | 2021-11-24 | 公開日 | 2022-01-12 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
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7YPK
| Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein | 著者 | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | 登録日 | 2022-08-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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3M6A
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4YPL
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7KSL
| Substrate-free human mitochondrial LONP1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | 登録日 | 2020-11-23 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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6U5Z
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6X1M
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7YUW
| MtaLon-ADP for the spiral oligomers of pentamer | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | 登録日 | 2022-08-18 | 公開日 | 2023-10-25 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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6WQH
| Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... | 著者 | Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. | 登録日 | 2020-04-28 | 公開日 | 2021-06-09 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J.Biol.Chem., 297, 2021
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8EMC
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8EMH
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7YPH
| Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | 分子名称: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | 登録日 | 2022-08-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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