PDB: 76 件ウェブページステータス検索Chemie searchBIRD

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7FD5	A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... 著者 Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. 登録日 2021-07-16 公開日 2021-11-03 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
7FID	Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. 登録日 2021-07-31 公開日 2021-11-24 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.44 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
6WZV	Lon protease proteolytic domain 分子名称: Lon protease homolog, mitochondrial, N-[(1R)-1-borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide, ... 著者 Lee, C.C, Spraggon, G. 登録日 2020-05-14 公開日 2021-04-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology. J.Med.Chem., 64, 2021
7P09	Human mitochondrial Lon protease with substrate in the ATPase domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-29 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
7P0M	Human mitochondrial Lon protease with substrate in the ATPase and protease domains 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-30 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
8OJL	Human Mitochondrial Lon Y394E Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-03-24 公開日 2024-04-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
1Z0V	Crystal Structure of A. fulgidus Lon proteolytic domain 分子名称: Putative protease La homolog type 著者 Dauter, Z, Botos, I, LaRonde-LeBlanc, N, Wlodawer, A. 登録日 2005-03-02 公開日 2005-08-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Pathological crystallography: case studies of several unusual macromolecular crystals. Acta Crystallogr.,Sect.D, 61, 2005
1Z0T	Crystal Structure of A. fulgidus Lon proteolytic domain 分子名称: Putative protease La homolog type 著者 Dauter, Z, Botos, I, LaRonde-LeBlanc, N, Wlodawer, A. 登録日 2005-03-02 公開日 2005-08-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Pathological crystallography: case studies of several unusual macromolecular crystals. Acta Crystallogr.,Sect.D, 61, 2005
6ON2	Lon Protease from Yersinia pestis with Y2853 substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ... 著者 Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. 登録日 2019-04-19 公開日 2019-05-01 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
5E7S	Hexameric structure of a LonA protease domain in active state 分子名称: Lon protease 著者 Lin, C.-C, Su, S.-C, Chang, C.-I. 登録日 2015-10-13 公開日 2016-03-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease Structure, 24, 2016
7KSM	Human mitochondrial LONP1 with endogenous substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. 登録日 2020-11-23 公開日 2020-12-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7KRZ	Human mitochondrial LONP1 in complex with Bortezomib 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... 著者 Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. 登録日 2020-11-20 公開日 2021-02-24 最終更新日 2022-06-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7FIZ	Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. 登録日 2021-08-01 公開日 2021-11-24 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
7SXO	Yeast Lon (PIM1) with endogenous substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. 登録日 2021-11-24 公開日 2022-01-12 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
7YPK	Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein 著者 Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. 登録日 2022-08-03 公開日 2023-10-25 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
3M6A	Crystal structure of Bacillus subtilis Lon C-terminal domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease La 1 著者 Duman, R.E, Lowe, J.Y. 登録日 2010-03-15 公開日 2010-06-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal Structures of Bacillus subtilis Lon Protease. J.Mol.Biol., 401, 2010
4YPL	Crystal structure of a hexameric LonA protease bound to three ADPs 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, N-[(1R)-1-(dihydroxyboranyl)-2-phenylethyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide 著者 Lin, C.-C, Chang, C.-I. 登録日 2015-03-13 公開日 2016-03-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structural Insights into the Allosteric Operation of the Lon AAA+ Protease Structure, 24, 2016
6U5Z	Cryo-EM structure of E. coli LonA S679A 分子名称: Lon protease 著者 Botos, I, Lountos, G.T, Weimin, W, Wlodawer, A. 登録日 2019-08-28 公開日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery Curr Res Struct Biol, 1, 2020
7KSL	Substrate-free human mitochondrial LONP1 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. 登録日 2020-11-23 公開日 2020-12-09 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
6X1M	Lon protease proteolytic domain complexed with covalent boronic acid inhibitor 分子名称: Lon protease homolog, mitochondrial, [(1R)-4-phenyl-1-{[N-(pyrazine-2-carbonyl)-D-norvalyl]amino}butyl]boronic acid 著者 Lee, C.C, Spraggon, G. 登録日 2020-05-19 公開日 2021-04-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.51 Å) 主引用文献 Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology. J.Med.Chem., 64, 2021
7YUW	MtaLon-ADP for the spiral oligomers of pentamer 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease 著者 Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. 登録日 2022-08-18 公開日 2023-10-25 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
6WQH	Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease 分子名称: ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... 著者 Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. 登録日 2020-04-28 公開日 2021-06-09 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J.Biol.Chem., 297, 2021
8EMC	CryoEM characterization of BrxL -- a unique AAA+ phage restriction Factor. 分子名称: Protease Lon-related BREX system protein BrxL 著者 Shen, B.W, Stoddard, B.L. 登録日 2022-09-27 公開日 2023-02-01 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor. Nucleic Acids Res., 51, 2023
8EMH	CryoEM characterization of a unique AAA+ BrxL phage restriction factor 分子名称: DNA (63-MER), DNA (64-MER), Protease Lon-related BREX system protein BrxL 著者 Shen, B.W, Stoddard, B.L. 登録日 2022-09-27 公開日 2023-02-01 最終更新日 2023-05-17 実験手法 ELECTRON MICROSCOPY (3.63 Å) 主引用文献 Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor. Nucleic Acids Res., 51, 2023
7YPH	Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation 分子名称: Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. 登録日 2022-08-03 公開日 2023-10-25 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023

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