PDB: 76 件ウェブページステータス検索Chemie searchBIRD

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7EV4	Crystal structure of the Lon-like protease MtaLonC with S582A mutation in complex with F-b20-Q 分子名称: Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION 著者 Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. 登録日 2021-05-20 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
7EV6	Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with F-b20-Q 分子名称: Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION 著者 Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. 登録日 2021-05-20 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
7EUY	Crystal structure of the Lon-like protease MtaLonC with D582A mutation in complex with substrate polypeptide 分子名称: ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION 著者 Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. 登録日 2021-05-19 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
7EUX	Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with substrate polypeptide 分子名称: ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION 著者 Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. 登録日 2021-05-19 公開日 2021-11-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
6ON2	Lon Protease from Yersinia pestis with Y2853 substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ... 著者 Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. 登録日 2019-04-19 公開日 2019-05-01 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
7SXO	Yeast Lon (PIM1) with endogenous substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. 登録日 2021-11-24 公開日 2022-01-12 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
6V11	Lon Protease from Yersinia pestis 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease 著者 Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. 登録日 2019-11-19 公開日 2020-01-22 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
3K1J	Crystal structure of Lon protease from Thermococcus onnurineus NA1 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Cha, S.S, An, Y.J. 登録日 2009-09-28 公開日 2010-09-22 最終更新日 2014-02-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber Embo J., 29, 2010
6U5Z	Cryo-EM structure of E. coli LonA S679A 分子名称: Lon protease 著者 Botos, I, Lountos, G.T, Weimin, W, Wlodawer, A. 登録日 2019-08-28 公開日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery Curr Res Struct Biol, 1, 2020
4YPL	Crystal structure of a hexameric LonA protease bound to three ADPs 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, N-[(1R)-1-(dihydroxyboranyl)-2-phenylethyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide 著者 Lin, C.-C, Chang, C.-I. 登録日 2015-03-13 公開日 2016-03-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structural Insights into the Allosteric Operation of the Lon AAA+ Protease Structure, 24, 2016
3M6A	Crystal structure of Bacillus subtilis Lon C-terminal domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease La 1 著者 Duman, R.E, Lowe, J.Y. 登録日 2010-03-15 公開日 2010-06-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal Structures of Bacillus subtilis Lon Protease. J.Mol.Biol., 401, 2010
7KSL	Substrate-free human mitochondrial LONP1 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. 登録日 2020-11-23 公開日 2020-12-09 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7KSM	Human mitochondrial LONP1 with endogenous substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. 登録日 2020-11-23 公開日 2020-12-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7KRZ	Human mitochondrial LONP1 in complex with Bortezomib 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... 著者 Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. 登録日 2020-11-20 公開日 2021-02-24 最終更新日 2022-06-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7P0M	Human mitochondrial Lon protease with substrate in the ATPase and protease domains 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-30 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
7P09	Human mitochondrial Lon protease with substrate in the ATPase domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-29 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
7P0B	Human mitochondrial Lon protease without substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-29 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
7P6U	Lon protease from Thermus Thermophilus 分子名称: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK), Lon protease, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Coscia, F, Lowe, J. 登録日 2021-07-18 公開日 2021-10-27 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of the full-length Lon protease from Thermus thermophilus. Febs Lett., 595, 2021
7OXO	human LonP1, R-state, incubated in AMPPCP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Abrahams, J.P, Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T. 登録日 2021-06-22 公開日 2021-12-22 最終更新日 2022-11-09 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
6WQH	Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease 分子名称: ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... 著者 Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. 登録日 2020-04-28 公開日 2021-06-09 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J.Biol.Chem., 297, 2021
8K3Y	The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease 著者 Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. 登録日 2023-07-17 公開日 2023-10-25 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (4.42 Å) 主引用文献 A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
8OKA	Human Mitochondrial Lon Y394F Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-03-28 公開日 2024-04-10 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
8OM7	Human Mitochondrial Lon Y186E Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-03-31 公開日 2024-04-10 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
8OJL	Human Mitochondrial Lon Y394E Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-03-24 公開日 2024-04-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
8OVF	Human Mitochondrial Lon Y186F Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-04-26 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (7.23 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024

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