PDB: 37 件ウェブページステータス検索Chemie searchBIRD

---

8IZY	Human KCNQ2-CaM in complex with HN37 分子名称: Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate 著者 Ma, D, Li, X, Guo, J. 登録日 2023-04-09 公開日 2023-11-29 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J00	Human KCNQ2-CaM in complex with CBD 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol 著者 Ma, D, Li, X, Guo, J. 登録日 2023-04-09 公開日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J01	Human KCNQ2-CaM in complex with CBD and PIP2 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... 著者 Ma, D, Li, X, Guo, J. 登録日 2023-04-09 公開日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J02	Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... 著者 Ma, D, Li, X, Guo, J. 登録日 2023-04-09 公開日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J03	Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol 著者 Ma, D, Li, D, Guo, J. 登録日 2023-04-09 公開日 2023-12-06 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J04	Human KCNQ2-CaM-HN37 complex in the presence of PIP2 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate 著者 Ma, D, Li, X, Guo, J. 登録日 2023-04-09 公開日 2023-12-06 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J05	Human KCNQ2-CaM complex in the presence of PIP2 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2 著者 Ma, D, Li, X, Guo, J. 登録日 2023-04-09 公開日 2023-12-06 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8SIK	KCNQ1 with voltage sensor in the up conformation 分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 著者 Mandala, V.S, MacKinnon, R. 登録日 2023-04-16 公開日 2023-05-31 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel. Proc.Natl.Acad.Sci.USA, 120, 2023
8SIM	KCNQ1 with voltage sensor in the intermediate conformation 分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 著者 Mandala, V.S, MacKinnon, R. 登録日 2023-04-16 公開日 2023-05-31 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel. Proc.Natl.Acad.Sci.USA, 120, 2023
8SIN	KCNQ1 with voltage sensor in the down conformation 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 著者 Mandala, V.S, MacKinnon, R. 登録日 2023-04-16 公開日 2023-05-31 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel. Proc.Natl.Acad.Sci.USA, 120, 2023
8W4U	human KCNQ2-CaM in complex with PIP2 and HN37 分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... 著者 Ma, D, Li, X, Guo, J. 登録日 2023-08-25 公開日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8X43	human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2 分子名称: Calmodulin-1, N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 著者 Ma, D, Guo, J. 登録日 2023-11-15 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol., 2024

<12