1I83
| BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1,N14-BIS((S-METHYL)ISOTHIOUREIDO)TETRADECANE (H4B FREE) | 分子名称: | ACETATE ION, GLYCEROL, N1,N14-BIS((S-METHYL)ISOTHIOUREIDO)TETRADECANE, ... | 著者 | Raman, C.S, Li, H, Martasek, P, Babu, B.R, Griffith, O.W, Masters, B.S.S, Poulos, T.L. | 登録日 | 2001-03-12 | 公開日 | 2001-08-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J.Biol.Chem., 276, 2001
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1JWJ
| Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457F Mutation at Tetrahydrobiopterin Binding Site | 分子名称: | 1,2-ETHANEDIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ... | 著者 | Aoyagi, M, Arvai, A.S, Ghosh, S, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2001-09-04 | 公開日 | 2001-10-31 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. Biochemistry, 40, 2001
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1JWK
| Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457A Mutation at Tetrahydrobiopterin Binding Site | 分子名称: | 1,2-ETHANEDIOL, 7,8-DIHYDROBIOPTERIN, GLYCEROL, ... | 著者 | Aoyagi, M, Arvai, A.S, Ghosh, S, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2001-09-04 | 公開日 | 2001-10-31 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. Biochemistry, 40, 2001
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1K2R
| Structure of rat brain nNOS heme domain complexed with NG-nitro-L-arginine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-OMEGA-NITRO-L-ARGININE, ... | 著者 | Li, H, Martasek, P, Masters, B.S.S, Poulos, T.L, Raman, C.S. | 登録日 | 2001-09-28 | 公開日 | 2003-03-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure of rat brain nNOS heme domain To be Published
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1K2S
| Structure of rat brain nNOS heme domain complexed with NG-allyl-L-arginine | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 5-N-ALLYL-ARGININE, ACETATE ION, ... | 著者 | Li, H, Martasek, P, Masters, B.S.S, Poulos, T.L, Raman, C.S. | 登録日 | 2001-09-28 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of rat brain nNOS heme domain To be Published
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1K2T
| Structure of rat brain nNOS heme domain complexed with S-ethyl-N-phenyl-isothiourea | 分子名称: | 2-ETHYL-1-PHENYL-ISOTHIOUREA, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Li, H, Martasek, P, Masters, B.S.S, Poulos, T.L, Raman, C.S. | 登録日 | 2001-09-28 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of rat brain nNOS heme domain To be Published
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1K2U
| Structure of rat brain nNOS heme domain complexed with S-ethyl-N-[4-(trifluoromethyl)phenyl] isothiourea | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Li, H, Martasek, P, Masters, B.S.S, Poulos, T.L, Raman, C.S. | 登録日 | 2001-09-28 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of rat brain nNOS heme domain To be Published
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1LZX
| Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-OMEGA-HYDROXY-L-ARGININE, ... | 著者 | Li, H, Shimizu, H, Flinspach, M, Jamal, J, Yang, W, Xian, M, Cai, T, Wen, E.Z, Jia, Q, Wang, P.G, Poulos, T.L. | 登録日 | 2002-06-11 | 公開日 | 2002-11-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide
Synthase Provides Mechanistic Insights into NO Biosynthesis Biochemistry, 41, 2002
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1LZZ
| Rat neuronal NOS heme domain with N-isopropyl-N'-hydroxyguanidine bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-ISOPROPYL-N'-HYDROXYGUANIDINE, ... | 著者 | Li, H, Shimizu, H, Flinspach, M, Jamal, J, Yang, W, Xian, M, Cai, T, Wen, E.Z, Jia, Q, Wang, P.G, Poulos, T.L. | 登録日 | 2002-06-11 | 公開日 | 2002-11-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide
Synthase Provides Mechanistic Insights into NO Biosynthesis Biochemistry, 41, 2002
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1M00
| Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-BUTYL-N'-HYDROXYGUANIDINE, ... | 著者 | Li, H, Shimizu, H, Flinspach, M, Jamal, J, Yang, W, Xian, M, Cai, T, Wen, E.Z, Jia, Q, Wang, P.G, Poulos, T.L. | 登録日 | 2002-06-11 | 公開日 | 2002-11-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide
Synthase Provides Mechanistic Insights into NO Biosynthesis Biochemistry, 41, 2002
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1M7V
| STRUCTURE OF A NITRIC OXIDE SYNTHASE HEME PROTEIN FROM BACILLUS SUBTILIS WITH TETRAHYDROFOLATE AND ARGININE BOUND | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, ARGININE, Nitric Oxide Synthase, ... | 著者 | Pant, K, Bilwes, A.M, Adak, S, Stuehr, D.J, Crane, B.R. | 登録日 | 2002-07-22 | 公開日 | 2002-10-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of a nitric oxide synthase heme protein from Bacillus subtilis. Biochemistry, 41, 2002
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1M7Z
| Structure of Nitric Oxide Synthase Heme Protein from Bacillus Subtilis with N-Hydroxy-Arginine and Tetrahydrofolate Bound | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, N-OMEGA-HYDROXY-L-ARGININE, Nitric oxide synthase, ... | 著者 | Pant, K, Bilwes, A.M, Adak, S, Stuehr, D.J, Crane, B.R. | 登録日 | 2002-07-23 | 公開日 | 2002-10-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Structure of a nitric oxide synthase heme protein from Bacillus subtilis. Biochemistry, 41, 2002
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1M8D
| inducible nitric oxide synthase with Chlorzoxazone bound | 分子名称: | 1,2-ETHANEDIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, CHLORZOXAZONE, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-24 | 公開日 | 2002-08-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M8E
| inducible nitric oxide synthase with 7-nitroindazole bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 7-NITROINDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-24 | 公開日 | 2002-08-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M8H
| inducible nitric oxide synthase with 6-nitroindazole bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-NITROINDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-24 | 公開日 | 2002-08-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M8I
| inducible nitric oxide synthase with 5-nitroindazole bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 5-NITROINDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-24 | 公開日 | 2002-08-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M9J
| human endothelial nitric oxide synthase with chlorzoxazone bound | 分子名称: | CHLORZOXAZONE, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-29 | 公開日 | 2002-08-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M9K
| Human Endothelial Nitric Oxide Synthase with 7-Nitroindazole Bound | 分子名称: | 7-NITROINDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-29 | 公開日 | 2002-08-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M9M
| human endothelial nitric oxide synthase with 6-nitroindazole bound | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 6-NITROINDAZOLE, ISOPROPYL ALCOHOL, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-29 | 公開日 | 2002-08-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M9Q
| human endothelial nitric oxide synthase with 5-nitroindazole bound | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-NITROINDAZOLE, ISOPROPYL ALCOHOL, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-29 | 公開日 | 2002-08-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M9R
| human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound | 分子名称: | 3-BROMO-7-NITROINDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-07-29 | 公開日 | 2002-08-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1M9T
| Inducible Nitric Oxide Synthase with 3-Bromo-7-Nitroindazole bound | 分子名称: | 1,2-ETHANEDIOL, 3-BROMO-7-NITROINDAZOLE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... | 著者 | Rosenfeld, R.J, Garcin, E.D, Panda, K, Andersson, G, Aberg, A, Wallace, A.V, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2002-09-05 | 公開日 | 2002-09-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency Biochemistry, 41, 2002
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1MJT
| CRYSTAL STRUCTURE OF SANOS, A BACTERIAL NITRIC OXIDE SYNTHASE OXYGENASE PROTEIN, IN COMPLEX WITH NAD+ AND SEITU | 分子名称: | ETHYLISOTHIOUREA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NITRIC-OXIDE SYNTHASE HOMOLOG, ... | 著者 | Bird, L.E, Ren, J, Stammers, D.K. | 登録日 | 2002-08-28 | 公開日 | 2003-01-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus Structure, 10, 2002
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1MMV
| Rat neuronal NOS heme domain with NG-propyl-L-arginine bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-OMEGA-PROPYL-L-ARGININE, ... | 著者 | Bretscher, L.E, Li, H, Poulos, T.L, Griffith, O.W. | 登録日 | 2002-09-04 | 公開日 | 2003-09-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines J.Biol.Chem., 278, 2003
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1MMW
| Rat neuronal NOS heme domain with vinyl-L-NIO bound | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N5-(1-IMINO-3-BUTENYL)-L-ORNITHINE, ... | 著者 | Bretscher, L.E, Li, H, Poulos, T.L, Griffith, O.W. | 登録日 | 2002-09-04 | 公開日 | 2003-09-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines J.Biol.Chem., 278, 2003
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