PDB: 95 件ウェブページステータス検索Chemie searchBIRD

---

6G2H	Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution 分子名称: Acetyl-CoA carboxylase 1 著者 Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T. 登録日 2018-03-23 公開日 2018-06-13 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 558, 2018
5VJ1	Crystal structure of a Pseudomonas malonate decarboxylase hetero-tetramer in complex with coenzyme A 分子名称: CHLORIDE ION, COENZYME A, MdcA, ... 著者 Maderbocus, R, Tong, L. 登録日 2017-04-18 公開日 2017-08-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nat Commun, 8, 2017
5VIT	Crystal structure of a Pseudomonas malonate decarboxylase hetero-tetramer in complex with malonate 分子名称: MALONATE ION, MdcA, MdcC, ... 著者 Maderbocus, R, Tong, L. 登録日 2017-04-17 公開日 2017-08-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nat Commun, 8, 2017
5VIP	Crystal structure of Pseudomonas malonate decarboxylase MdcD-MdcE hetero-dimer 分子名称: MdcD, MdcE 著者 Maderbocus, R, Tong, L. 登録日 2017-04-17 公開日 2017-08-16 実験手法 X-RAY DIFFRACTION (1.857 Å) 主引用文献 Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nat Commun, 8, 2017
5KDR	The crystal structure of carboxyltransferase from Staphylococcus Aureus bound to the antimicrobial agent moiramide B. 分子名称: 1,2-ETHANEDIOL, Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ... 著者 Silvers, M.A, Pakhomova, S, Neau, D, Silvers, W.C, Anzalone, N, Taylor, C.M, Waldrop, G.L. 登録日 2016-06-08 公開日 2016-08-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B. Biochemistry, 55, 2016
5INI	Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics 分子名称: HEXANOYL-COENZYME A, Putative carboxyl transferase 著者 Valentic, T.R, Ray, L, Miyazawa, T, Withall, D.M, Song, L, Milligan, J.C, Osada, H, Tsai, S.C, Challis, G.L. 登録日 2016-03-07 公開日 2016-12-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun, 7, 2016
5ING	A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender unit 分子名称: Putative carboxyl transferase 著者 Valentic, T.R, Ray, L, Miyazawa, T, Song, L, Withall, D.M, Milligan, J.C, Takahashi, S, Osada, H, Tsai, S.C, Challis, G.L. 登録日 2016-03-07 公開日 2016-12-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun, 7, 2016
5INF	Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics 分子名称: Carboxyl transferase, HEXANOYL-COENZYME A 著者 Valentic, T.R, Ray, L, Miyazawa, T, Withall, D.M, Song, L, Osada, H, Tsai, S.C, Challis, G.L. 登録日 2016-03-07 公開日 2016-12-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.751 Å) 主引用文献 A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun, 7, 2016
5IKL	Crystal structure of P. aeruginosa geranyl-CoA carboxylase (GCC), beta subunit 分子名称: Geranyl-CoA carboxylase, beta-subunit 著者 Huang, C.S, Jurado, A.R, Tong, L. 登録日 2016-03-03 公開日 2016-04-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and substrate selectivity of the 750-kDa alpha6beta6 holoenzyme of geranyl-CoA carboxylase Nat Commun, 6, 2015
5I6F	Crystal structure of C-terminal variant 1 of Chaetomium thermophilum acetyl-CoA carboxylase 分子名称: Acetyl-CoA carboxylase-like protein 著者 Hunkeler, M, Stuttfeld, E, Hagmann, A, Imseng, S, Maier, T. 登録日 2016-02-16 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 The dynamic organization of fungal acetyl-CoA carboxylase. Nat Commun, 7, 2016
5I6G	Crystal structure of C-terminal variant 2 of Chaetomium thermophilum acetyl-CoA carboxylase 分子名称: Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein 著者 Hunkeler, M, Stuttfeld, E, Hagmann, A, Imseng, S, Maier, T. 登録日 2016-02-16 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 The dynamic organization of fungal acetyl-CoA carboxylase. Nat Commun, 7, 2016
5I6H	Crystal structure of CD-CT domains of Chaetomium thermophilum acetyl-CoA carboxylase 分子名称: Acetyl-CoA carboxylase-like protein 著者 Hunkeler, M, Stuttfeld, E, Hagmann, A, Imseng, S, Maier, T. 登録日 2016-02-16 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (7.2 Å) 主引用文献 The dynamic organization of fungal acetyl-CoA carboxylase. Nat Commun, 7, 2016
5I6I	Crystal structure of a dBCCP-variant of Chaetomium thermophilum acetyl-CoA carboxylase 分子名称: Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein 著者 Hunkeler, M, Stuttfeld, E, Hagmann, A, Imseng, S, Maier, T. 登録日 2016-02-16 公開日 2016-04-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (8.4 Å) 主引用文献 The dynamic organization of fungal acetyl-CoA carboxylase. Nat Commun, 7, 2016
5FIF	Carboxyltransferase domain of a single-chain bacterial carboxylase 分子名称: 1,2-ETHANEDIOL, Carboxylase 著者 Hagmann, A, Hunkeler, M, Stuttfeld, E, Maier, T. 登録日 2015-12-23 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.494 Å) 主引用文献 Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans. Structure, 24, 2016
5CSL	Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Acetyl-CoA carboxylase, COENZYME A 著者 Wei, J, Tong, L. 登録日 2015-07-23 公開日 2015-10-28 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature, 526, 2015
5CTC	Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate 分子名称: Acetyl-CoA carboxylase, SULFATE ION, tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate 著者 Vajdos, F.F. 登録日 2015-07-23 公開日 2015-10-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25, 2015
5CTB	Humanized yeast ACC carboxyltransferase domain bound to 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one 分子名称: 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one, Acetyl-CoA carboxylase, SULFATE ION 著者 Vajdos, F.F. 登録日 2015-07-23 公開日 2015-10-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25, 2015
5CSK	Crystal structure of yeast acetyl-CoA carboxylase, unbiotinylated 分子名称: Acetyl-CoA carboxylase 著者 Wei, J, Tong, L. 登録日 2015-07-23 公開日 2015-10-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature, 526, 2015
5CTE	Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate 分子名称: 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, Acetyl-CoA carboxylase, SULFATE ION 著者 Vajdos, F.F. 登録日 2015-07-23 公開日 2015-10-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25, 2015
4WZ8	Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6 分子名称: 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one, Acetyl-CoA carboxylase 著者 Vajdos, F.F. 登録日 2014-11-18 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J.Med.Chem., 57, 2014
4WYO	Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 1 分子名称: 2'-tert-butyl-1-(2H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one, Acetyl-CoA carboxylase 著者 Vajdos, F.F. 登録日 2014-11-17 公開日 2015-01-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J.Med.Chem., 57, 2014
4RCN	Structure and function of a single-chain, multi-domain long-chain acyl-coa carboxylase 分子名称: long-chain acyl-CoA carboxylase 著者 Tran, T.H, Tong, L. 登録日 2014-09-16 公開日 2014-11-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase. Nature, 518, 2015
4Q0G	Crystal structure of beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis 分子名称: GLYCEROL, Probable acetyl-/propionyl-CoA carboxylase (Beta subunit) AccD1 著者 Bie, H.Y, Yin, J, James, M.N.G, TB Structural Genomics Consortium (TBSGC) 登録日 2014-04-02 公開日 2016-04-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of Beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis To be Published
4L6W	Carboxyltransferase subunit (AccD6) of Mycobacterium tuberculosis acetyl-CoA carboxylase 分子名称: Probable propionyl-CoA carboxylase beta chain 6 著者 Anandhakrishnan, M, Ehebauer, M.T, Wilmanns, M. 登録日 2013-06-13 公開日 2013-07-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural analysis of the carboxyltransferase subunit of Mycobacterium tuberculosis acetyl-CoA carboxylase To be Published
4G2R	Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis 分子名称: (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase 著者 Reddy, M.C.M, Bruning, J.B, Thurman, C, Sherekar, M, Valluru, S, Ehrenfeld, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2012-07-12 公開日 2014-02-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrob.Agents Chemother., 58, 2014

<1234>