PDB: 141 件ウェブページステータス検索Chemie searchBIRD

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3JZY	Crystal structure of human Intersectin 2 C2 domain 分子名称: Intersectin 2, UNKNOWN ATOM OR ION 著者 Shen, Y, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-09-24 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Crystal structure of human Intersectin 2 C2 domain To be Published
3KSY	Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS) 分子名称: Son of sevenless homolog 1 著者 Gureasko, J, Kuchment, O, Kuriyan, J. 登録日 2009-11-24 公開日 2010-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.178 Å) 主引用文献 Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc.Natl.Acad.Sci.USA, 107, 2010
3KY9	Autoinhibited Vav1 分子名称: Proto-oncogene vav, ZINC ION 著者 Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B. 登録日 2009-12-04 公開日 2010-02-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.731 Å) 主引用文献 Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 Cell(Cambridge,Mass.), 140, 2010
3KZ1	Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ... 著者 Chen, Z, Sternweis, P.C, Sprang, S.R. 登録日 2009-12-07 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285, 2010
3MPX	Crystal structure of the DH and PH-1 domains of human FGD5 分子名称: FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION 著者 Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-04-27 公開日 2010-06-23 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the DH and PH-1 domains of human FGD5 TO BE PUBLISHED
3JV3	Structure of SH3E-DH unit of murine intersectin-1L 分子名称: Intersectin-1 著者 Ahmad, K.F. 登録日 2009-09-15 公開日 2010-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. Plos One, 5, 2010
2KR9	Kalirin DH1 NMR structure 分子名称: Kalirin 著者 Gorbatyuk, V.Y, Schiller, M.R, Hoch, J.C. 登録日 2009-12-10 公開日 2010-12-15 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 The solution NMR structure of the first Dbl domain of RhoGEF Kalirin. To be Published
3ODX	Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-12 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3ODW	Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3ODO	Crystal Structure of the DH/PH Domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3P6A	Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant) 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-10-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3T06	Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA 分子名称: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA 著者 Bielnicki, J.A, Derewenda, U, Derewenda, Z.S. 登録日 2011-07-19 公開日 2011-08-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF. J.Biol.Chem., 286, 2011
3QBV	Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin 分子名称: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1 著者 Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T. 登録日 2011-01-14 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc.Natl.Acad.Sci.USA, 109, 2012
4GOU	Crystal structure of an RGS-RhoGEF from Entamoeba histolytica 分子名称: EhRGS-RhoGEF 著者 Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P. 登録日 2012-08-20 公開日 2013-01-09 最終更新日 2013-01-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis. Structure, 21, 2013
4GYV	Crystal structure of the DH domain of FARP2 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 2 著者 He, X, Zhang, X. 登録日 2012-09-05 公開日 2013-03-13 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4GZU	Crystal structure of the DH-PH-PH domain of FARP2 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 2 著者 He, X, Zhang, X. 登録日 2012-09-06 公開日 2013-03-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4H6Y	Crystal structure of the DH-PH-PH domain of FARP1 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 1 著者 He, X, Zhang, X. 登録日 2012-09-19 公開日 2013-03-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4.09 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4D0N	AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA 分子名称: 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. 登録日 2014-04-29 公開日 2014-05-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
4D0O	AKAP13 (AKAP-Lbc) DH domain 分子名称: A-KINASE ANCHOR PROTEIN 13 著者 Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. 登録日 2014-04-29 公開日 2014-05-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
4MT7	Crystal structure of collybistin I 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
4MT6	Crystal structure of closed inactive collybistin 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (5.501 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
4XH9	CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1 分子名称: Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA 著者 Garcia, C, Petit, P, Boutin, J.A, Ferry, G, Vuillard, L. 登録日 2015-01-05 公開日 2015-01-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. J. Biol. Chem., 293, 2018
4YON	P-Rex1:Rac1 complex 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Lucato, C.M, Whisstock, J.C, Ellisdon, A.M. 登録日 2015-03-11 公開日 2015-07-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J.Biol.Chem., 290, 2015
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
5FI0	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 分子名称: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.282 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016

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