PDB: 151 件ウェブページステータス検索Chemie searchBIRD

---

1YG6	ClpP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit 著者 Bewley, M.C, Graziano, V, Griffin, K, Flanagan, J.M. 登録日 2005-01-04 公開日 2006-04-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes. J.Struct.Biol., 153, 2006
5G1S	Open conformation of Francisella tularensis ClpP at 1.7 A 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... 著者 Diaz-Saez, L, Pankov, G, Hunter, W.N. 登録日 2016-03-30 公開日 2016-10-19 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Open and compressed conformations of Francisella tularensis ClpP. Proteins, 85, 2017
7M1M	Crystal structure of Pseudomonas aeruginosa ClpP1 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit 著者 Mawla, G.D, Grant, R.A, Baker, T.A, Sauer, R.T. 登録日 2021-03-13 公開日 2021-03-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa. Mol.Microbiol., 115, 2021
7M1L	Crystal structure of Pseudomonas aeruginosa ClpP2 分子名称: ATP-dependent Clp protease proteolytic subunit, PHOSPHATE ION 著者 Hall, B.M, Grant, R.A, Baker, T.A, Sauer, R.T. 登録日 2021-03-13 公開日 2021-03-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa. Mol.Microbiol., 115, 2021
5G1R	Open conformation of Francisella tularensis ClpP at 1.9 A 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... 著者 Diaz-Saez, L, Hunter, W.N. 登録日 2016-03-29 公開日 2016-10-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Open and compressed conformations of Francisella tularensis ClpP. Proteins, 85, 2017
3P2L	Crystal Structure of ATP-dependent Clp protease subunit P from Francisella tularensis 分子名称: 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, DI(HYDROXYETHYL)ETHER, ... 著者 Kim, Y, Zhou, M, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-10-02 公開日 2010-10-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.295 Å) 主引用文献 Crystal Structure of ATP-dependent Clp protease subunit P from Francisella tularensis To be Published
7MK5	Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-[(1E)-3-{[(2E,4E,6E,8S)-8-hydroxy-4-methyldeca-2,4,6-trienoyl]amino}-3-oxoprop-1-en-1-yl]azete-1(2H)-carboxylic acid, ACETATE ION, ... 著者 Culp, E.J, Sychantha, D, Hobson, C, Pawlowski, A.J, Prehna, G, Wright, G.D. 登録日 2021-04-21 公開日 2022-02-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 ClpP inhibitors are produced by a widespread family of bacterial gene clusters. Nat Microbiol, 7, 2022
4RYF	ClpP1/2 heterocomplex from Listeria monocytogenes 分子名称: ATP-dependent Clp protease proteolytic subunit, MALONATE ION, SODIUM ION 著者 Dahmen, M, Vielberg, M.-T, Groll, M, Sieber, S.A. 登録日 2014-12-15 公開日 2014-12-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes. Angew.Chem.Int.Ed.Engl., 54, 2015
3QWD	Crystal structure of ClpP from Staphylococcus aureus 分子名称: ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION 著者 Geiger, S.R, Boettcher, T, Sieber, S.A, Cramer, P. 登録日 2011-02-28 公開日 2011-05-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Conformational Switch Underlies ClpP Protease Function. Angew.Chem.Int.Ed.Engl., 50, 2011
3Q7H	Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii 分子名称: ATP-dependent Clp protease proteolytic subunit, CALCIUM ION, DI(HYDROXYETHYL)ETHER 著者 Anderson, S.M, Wawrzak, Z, Gordon, E, Hasseman, J, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2011-01-04 公開日 2011-01-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii To be Published
4U0H	Crystal Structure of M. tuberculosis ClpP1P1 分子名称: ATP-dependent Clp protease proteolytic subunit 1, SULFATE ION 著者 Schmitz, K.R, Carney, D.W, Sello, J.K, Sauer, R.T. 登録日 2014-07-11 公開日 2014-10-08 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.2479 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc.Natl.Acad.Sci.USA, 111, 2014
4U0G	Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP and agonist 分子名称: ADEP-2B5Me, ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, ... 著者 Schmitz, K.R, Carney, D.W, Sello, J.K, Sauer, R.T. 登録日 2014-07-11 公開日 2014-10-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1978 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc.Natl.Acad.Sci.USA, 111, 2014
5G1Q	Compressed conformation of Francisella tularensis ClpP at 2.84 A 分子名称: CLP PROTEASE PROTEOLYTIC SUBUNIT P 著者 Diaz-Saez, L, Hunter, W.N. 登録日 2016-03-29 公開日 2016-10-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Open and compressed conformations of Francisella tularensis ClpP. Proteins, 85, 2017
4GM2	The crystal structure of a peptidase from plasmodium falciparum 分子名称: ATP-dependent Clp protease proteolytic subunit 著者 El Bakkouri, M, Jung, P, Wernimont, A.K, Calmettes, C, Hui, R, Houry, W.A, Structural Genomics Consortium (SGC) 登録日 2012-08-15 公開日 2012-12-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum. J.Biol.Chem., 288, 2013
4HNK	Crystal structure of an Enzyme 分子名称: ATP-dependent Clp protease proteolytic subunit, GLYCEROL 著者 El Bakkouri, M, Calmettes, C, Wernimont, A.K, Houry, W.A, Hui, R, Structural Genomics Consortium (SGC) 登録日 2012-10-19 公開日 2012-12-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum. J.Biol.Chem., 288, 2013
6HWM	Structure of Thermus thermophilus ClpP in complex with bortezomib 分子名称: ATP-dependent Clp protease proteolytic subunit, DI(HYDROXYETHYL)ETHER, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE 著者 Felix, J, Schanda, P, Fraga, H, Morlot, C. 登録日 2018-10-12 公開日 2019-09-18 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors. Sci Adv, 5, 2019
8R03	Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution 分子名称: 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) 著者 Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. 登録日 2023-10-30 公開日 2023-12-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8R05	Photorhabdus lamondii ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.5 A resolution 分子名称: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) 著者 Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. 登録日 2023-10-30 公開日 2023-12-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8R04	Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A 分子名称: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) 著者 Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. 登録日 2023-10-30 公開日 2023-12-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8QYF	Crystal structure of ClpP from Staphylococcus epidermidis in complex with ixazomib 分子名称: ATP-dependent Clp protease proteolytic subunit, [(1~{R})-1-[2-[[2,5-bis(chloranyl)phenyl]carbonylamino]ethanoylamino]-3-methyl-butyl]boronic acid 著者 Franca, B.A, Rohde, H, Betzel, C. 登録日 2023-10-26 公開日 2024-01-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds. Sci Rep, 14, 2024
6H23	Crystal structure of the hClpP Y118A mutant with an activating small molecule 分子名称: 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... 著者 Kick, L.M, Sieber, S.A, Schneider, S. 登録日 2018-07-13 公開日 2018-08-29 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.089 Å) 主引用文献 Selective Activation of Human Caseinolytic Protease P (ClpP). Angew. Chem. Int. Ed. Engl., 57, 2018
6IW7	structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease 分子名称: (2S)-2-benzamido-4-methyl-pentanoic acid, 4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline, ATP-dependent Clp protease proteolytic subunit 1, ... 著者 Bao, R, Luo, Y.F, Zhu, Y.B, Yang, Y, Zhou, Y.Z. 登録日 2018-12-04 公開日 2020-01-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.692121 Å) 主引用文献 structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease To Be Published
4JCQ	ClpP1 from Listeria monocytogenes 分子名称: ATP-dependent Clp protease proteolytic subunit 著者 Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S. 登録日 2013-02-22 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc.Natl.Acad.Sci.USA, 110, 2013
4JCT	ClpP2 from Listeria monocytogenes 分子名称: ATP-dependent Clp protease proteolytic subunit 著者 Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S. 登録日 2013-02-22 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc.Natl.Acad.Sci.USA, 110, 2013
6X60	ClpP2 from Chlamydia trachomatis with resolved handle loop 分子名称: ATP-dependent Clp protease proteolytic subunit 2 著者 Azadmanesh, J, Struble, L.R, Seleem, M.A, Ouellette, S, Conda-Sheridan, M, Borgstahl, G.E.O. 登録日 2020-05-27 公開日 2020-06-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 ClpP2 from Chlamydia trachomatis with resolved handle loop To Be Published

<1234567>