PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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5MTJ	Yes1-SH2 in complex with monobody Mb(Yes_1) 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ... 著者 Sha, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-09 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
5MTM	Monobody Mb(Lck_3) bound to Lck-SH2 domain 分子名称: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION 著者 Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-10 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.405 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
5MTN	Monobody Mb(Lck_1) bound to Lck-Sh2 分子名称: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck 著者 Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-10 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
6E8H	Legionella Longbeachae LeSH (Llo2327) 分子名称: CHLORIDE ION, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
3EAZ	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-26 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
3C7I	X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN. 分子名称: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide 著者 Benfield, A.P, Martin, S.F. 登録日 2008-02-07 公開日 2008-08-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 118, 2006
7SA7	Crystal structure of the apo SH2 domains of Syk 分子名称: Tyrosine-protein kinase SYK 著者 Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J. 登録日 2021-09-22 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci., 30, 2021
3IMJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic 分子名称: (1R,2S,3R,1S',1S")Phosphoric acid mono(4-{2-[1-(1,2-dicarbamoylethylcarbamoyl)-3-carbamoylpropylcarbamoyl]-3-methylcarbamoylcyclopropyl}phenyl) ester, Growth factor receptor-bound protein 2 著者 Clements, J.H. 登録日 2009-08-10 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IN8	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic 分子名称: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide 著者 Benfield, A.P, Clements, J.H. 登録日 2009-08-11 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
7Q63	The tandem SH2 domains of SYK 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. 登録日 2021-11-05 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The tandem SH2 domains of SYK To Be Published
7Q5W	The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide 分子名称: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ... 著者 Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. 登録日 2021-11-04 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The tandem SH2 domains of SYK To Be Published
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic 分子名称: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide 著者 Clements, J.H. 登録日 2009-08-11 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMD	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... 著者 Clements, J.H. 登録日 2009-08-10 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide 分子名称: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... 著者 Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide 分子名称: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION 著者 Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. 登録日 2021-12-02 公開日 2022-08-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
5JN0	CRK-II SH2 domain 分子名称: CHLORIDE ION, CRK-II SH2 domain 著者 Cho, J.-H. 登録日 2016-04-29 公開日 2017-08-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.677 Å) 主引用文献 CRK-II SH2 domain To Be Published
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... 著者 Clements, J.H. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
3K2M	Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex 分子名称: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1 著者 Wojcik, J.B, Duguid, E. 登録日 2009-09-30 公開日 2010-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17, 2010
5KAZ	Human SH2D1B structure 分子名称: SH2 domain-containing protein 1B, SULFATE ION 著者 Taha, M, Nezerwa, E, Nam, H.-J. 登録日 2016-06-02 公開日 2017-04-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The X-ray Crystallographic Structure of Human EAT2 (SH2D1B). Protein Pept. Lett., 23, 2016
6ICH	Grb2 SH2 domain in domain swapped dimer form 分子名称: Growth factor receptor-bound protein 2 著者 Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2018-09-06 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
5W3R	SH2B1 SH2 Domain 分子名称: PHENOL, PHOSPHATE ION, SH2B adapter protein 1 著者 McKercher, M.A, Wuttke, D.S. 登録日 2017-06-08 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.386 Å) 主引用文献 Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
5CDW	Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide 分子名称: Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN 著者 Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. 登録日 2015-07-05 公開日 2016-05-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
6HTF	Crystal structure of human Btk SH2 domain bound to rF10 repebody 分子名称: Tyrosine-protein kinase BTK, rF10 repebody 著者 Duarte, D.P, Pojer, F, Hantschel, O. 登録日 2018-10-04 公開日 2020-05-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.102 Å) 主引用文献 Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms. Nat Commun, 11, 2020
6WAY	C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide 分子名称: Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 著者 Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. 登録日 2020-03-26 公開日 2020-06-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020

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