PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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6E8M	Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide 分子名称: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8I	Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine 分子名称: LeSH (Llo2327), O-PHOSPHOTYROSINE 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6SM5	MbC/SHP1-C-SH2 complex 分子名称: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6 著者 Mann, G, Hantschel, O. 登録日 2019-08-21 公開日 2021-01-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 MbC/SHP1-C-SH2 complex To Be Published
6PXC	N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide 分子名称: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP 著者 Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. 登録日 2019-07-25 公開日 2019-12-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
6PXB	N-Terminal SH2 domain of the p120RasGAP 分子名称: Ras GTPase-activating protein 1 著者 Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. 登録日 2019-07-25 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.747 Å) 主引用文献 Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
6ROZ	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif 分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM) 著者 Krausze, J, Sikorska, J, Carlomagno, T. 登録日 2019-05-13 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
2YU7	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A 分子名称: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A 著者 Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-05 公開日 2008-04-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
5MTN	Monobody Mb(Lck_1) bound to Lck-Sh2 分子名称: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck 著者 Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-10 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
5MTJ	Yes1-SH2 in complex with monobody Mb(Yes_1) 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ... 著者 Sha, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-09 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
5MTM	Monobody Mb(Lck_3) bound to Lck-SH2 domain 分子名称: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION 著者 Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-10 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.405 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
4TZI	Structure of unliganded Lyn SH2 domain 分子名称: Tyrosine-protein kinase Lyn 著者 Wybenga-Groot, L.E. 登録日 2014-07-10 公開日 2015-01-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
4U1P	Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide 分子名称: Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... 著者 Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. 登録日 2014-07-16 公開日 2015-07-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide To Be Published
4U17	Swapped dimer of the human Fyn-SH2 domain 分子名称: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn 著者 Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. 登録日 2014-07-15 公開日 2015-07-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Swapped dimer of the human Fyn-SH2 domain To Be Published
7WFY	Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide 分子名称: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2 著者 Zhang, Y.J, Liu, Y.R, Wu, B. 登録日 2021-12-27 公開日 2022-12-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.449 Å) 主引用文献 Vav2 is a novel APP-interacting protein that regulates APP protein level. Sci Rep, 12, 2022
4F59	Triple mutant Src SH2 domain 分子名称: Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5A	Triple mutant Src SH2 domain bound to phosphate ion 分子名称: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5B	Triple mutant Src SH2 domain bound to phosphotyrosine 分子名称: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src 著者 Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. 登録日 2012-05-12 公開日 2012-10-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4FBN	Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. 登録日 2012-05-23 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
7MP3	Grb7-SH2 domain in complex with bicyclic peptide B8 分子名称: Growth factor receptor-bound protein 7, bicyclic peptide B8 著者 Colson, R, Wilce, M.C.J, Wilce, J.A. 登録日 2021-05-04 公開日 2022-02-02 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability. Biomedicines, 10, 2022
6WAX	C-terminal SH2 domain of p120RasGAP 分子名称: 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION 著者 Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. 登録日 2020-03-26 公開日 2020-06-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020
6WM1	Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl 分子名称: ACE-PTR-02K-ASN-PRA, CALCIUM ION, CHLORIDE ION, ... 著者 Martin, S.F, Clements, J.H. 登録日 2020-04-20 公開日 2020-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
6WO2	Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl 分子名称: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ... 著者 Martin, S.F, Clements, J.H. 登録日 2020-04-24 公開日 2020-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
7MPH	GRB2 SH2 Domain with Compound 7 分子名称: (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... 著者 Sun, L, Schonbrunn, E. 登録日 2021-05-04 公開日 2021-09-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
6WAY	C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide 分子名称: Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 著者 Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. 登録日 2020-03-26 公開日 2020-06-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020
6VK2	NMR solution structure of Grb2-SH2 domain at pH 7 分子名称: Growth factor receptor-bound protein 2 著者 Sanches, K, Caruso, I.P, Melo, F.A, Almeida, F.C.L. 登録日 2020-01-18 公開日 2020-07-29 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions. Sci Rep, 10, 2020

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