3QKA
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3QUE
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![BU of 3que by Molmil](/molmil-images/mine/3que) | Human p38 MAP Kinase in Complex with Skepinone-L | 分子名称: | 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Gruetter, C, Mayer-Wrangowski, S, Richters, A, Rauh, D. | 登録日 | 2011-02-23 | 公開日 | 2012-01-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat.Chem.Biol., 8, 2012
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3QLJ
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3QXI
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3QBN
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3QDF
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3QKC
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![BU of 3qkc by Molmil](/molmil-images/mine/3qkc) | CRYSTAL STRUCTURE OF geranyl diphosphate synthase small subunit from Antirrhinum majus | 分子名称: | Geranyl diphosphate synthase small subunit | 著者 | Malashkevich, V.N, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2011-01-31 | 公開日 | 2011-02-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of geranyl diphosphate synthase small subunit from Antirrhinum majus To be Published
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4G6C
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4G7F
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3QXZ
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3Q5K
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![BU of 3q5k by Molmil](/molmil-images/mine/3q5k) | Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of an inhibitor | 分子名称: | 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-2-{[2-(methylsulfanyl)ethyl]amino}benzamide, Heat shock protein 83-1 | 著者 | Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, MacKenzie, F, Fairlamb, A, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) | 登録日 | 2010-12-28 | 公開日 | 2011-02-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of an inhibitor To be Published
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3Q7T
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![BU of 3q7t by Molmil](/molmil-images/mine/3q7t) | 2.15A resolution structure (I41 Form) of the ChxR receiver domain from Chlamydia trachomatis | 分子名称: | SODIUM ION, Transcriptional regulatory protein | 著者 | Hickey, J, Lovell, S, Battaile, K.P, Hu, L, Middaugh, C.R, Hefty, P.S. | 登録日 | 2011-01-05 | 公開日 | 2011-07-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily. J.Biol.Chem., 286, 2011
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3QB3
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![BU of 3qb3 by Molmil](/molmil-images/mine/3qb3) | Crystal structure of Staphylococcal nuclease variant Delta+PHS I92KL25A at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Caro, J.A, Sue, G, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. | 登録日 | 2011-01-12 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Relocation of internal ionizable residues to cavities created by single alanine substitutions To be Published
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3QBP
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5A0F
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![BU of 5a0f by Molmil](/molmil-images/mine/5a0f) | Crystal structure of Yersinia Afp18-modified RhoA | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... | 著者 | Jank, T, Schimpl, M, van Aalten, D.M. | 登録日 | 2015-04-20 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos. Nat Commun, 6, 2015
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6R9T
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![BU of 6r9t by Molmil](/molmil-images/mine/6r9t) | Cryo-EM structure of autoinhibited human talin-1 | 分子名称: | Talin-1 | 著者 | Dedden, D, Schumacher, S, Zacharias, M, Biertumpfel, C, Mizuno, N. | 登録日 | 2019-04-04 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | The Architecture of Talin1 Reveals an Autoinhibition Mechanism. Cell, 179, 2019
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6R3V
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![BU of 6r3v by Molmil](/molmil-images/mine/6r3v) | Crystal Structure of RhoA-GDP-Pi in Complex with RhoGAP | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Jin, Y. | 登録日 | 2019-03-21 | 公開日 | 2019-05-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A GAP-GTPase-GDP-PiIntermediate Crystal Structure Analyzed by DFT Shows GTP Hydrolysis Involves Serial Proton Transfers. Chemistry, 25, 2019
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2RGN
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![BU of 2rgn by Molmil](/molmil-images/mine/2rgn) | Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | 著者 | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | 登録日 | 2007-10-04 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
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7SDP
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1EES
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![BU of 1ees by Molmil](/molmil-images/mine/1ees) | SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES | 分子名称: | GTP-BINDING PROTEIN, P21-ACTIVATED KINASE | 著者 | Gizachew, D, Guo, W, Chohan, K.C, Sutcliffe, M.J, Oswald, R.E. | 登録日 | 2000-02-02 | 公開日 | 2000-03-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase. Biochemistry, 39, 2000
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1EF0
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3OXI
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![BU of 3oxi by Molmil](/molmil-images/mine/3oxi) | Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases | 分子名称: | Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 8 interacting protein 1, methyl 3-[(thiophen-2-ylacetyl)amino]thiophene-2-carboxylate | 著者 | Hom, R.K, Bowers, S, Sealy, J, Truong, A, Probst, G.D, Neitzel, M, Neitz, J, Fang, L, Brogley, L, Wu, J, Konradi, A.W, Sham, H, Toth, G, Pan, H, Yao, N, Artis, D.R. | 登録日 | 2010-09-21 | 公開日 | 2011-05-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg.Med.Chem.Lett., 20, 2010
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3NPC
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![BU of 3npc by Molmil](/molmil-images/mine/3npc) | Crystal structure of JNK2 complexed with BIRB796 | 分子名称: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Mitogen-activated protein kinase 9 | 著者 | Kuglstatter, A, Ghate, M. | 登録日 | 2010-06-28 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3NEW
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![BU of 3new by Molmil](/molmil-images/mine/3new) | p38-alpha complexed with Compound 10 | 分子名称: | 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14 | 著者 | Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D. | 登録日 | 2010-06-09 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6, 2011
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4V7S
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![BU of 4v7s by Molmil](/molmil-images/mine/4v7s) | Crystal structure of the E. coli ribosome bound to telithromycin. | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. | 登録日 | 2010-08-05 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.2547 Å) | 主引用文献 | Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
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