8TBM
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![BU of 8tbm by Molmil](/molmil-images/mine/8tbm) | Tricomplex of RMC-7977, KRAS G12V, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GLYCEROL, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8TBN
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![BU of 8tbn by Molmil](/molmil-images/mine/8tbn) | Tricomplex of RMC-7977, KRAS G12S, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8SVI
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![BU of 8svi by Molmil](/molmil-images/mine/8svi) | Ubiquitin variant i53:Mutant L67H with 53BP1 Tudor domain | 分子名称: | GLYCEROL, Tumor protein p53 binding protein 1, Ubiquitin Variant i53: Mutant L67H | 著者 | Partridge, J.R, Holden, J.K, Wibowo, A.S, Mulichak, A. | 登録日 | 2023-05-16 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15, 2024
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8SVJ
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![BU of 8svj by Molmil](/molmil-images/mine/8svj) | Ubiquitin variant i53: mutant VHH with 53BP1 Tudor domain | 分子名称: | GLYCEROL, Tumor protein p53 binding protein 1, Ubiquitin varient i53 mutant VHH | 著者 | Holden, J, Partridge, J.R, Wibowo, A.S, Mulichak, A. | 登録日 | 2023-05-16 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15, 2024
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8T2D
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![BU of 8t2d by Molmil](/molmil-images/mine/8t2d) | Ubiquitin variant i53:Mutant T12Y.T14E.L67R with 53BP1 Tudor domain | 分子名称: | Tumor protein p53 binding protein 1, Ubiquitin variant i53 | 著者 | Partridge, J.R, Holden, J.K, Wibowo, A.S, Mulichak, A. | 登録日 | 2023-06-05 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | 主引用文献 | Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15, 2024
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8SVG
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![BU of 8svg by Molmil](/molmil-images/mine/8svg) | Ubiquitin variant i53 in complex with 53BP1 Tudor domain | 分子名称: | Tumor protein p53 binding protein 1, Ubiquitin variant i53 | 著者 | Holden, J.K, Partridge, J.R, Wibowo, A.S, Mulichak, A. | 登録日 | 2023-05-16 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15, 2024
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8SVH
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![BU of 8svh by Molmil](/molmil-images/mine/8svh) | Ubiquitin variant i53 mutant L67R bound to 53BP1 Tudor Domain | 分子名称: | Tumor protein p53 binding protein 1, Ubiquitin variant i53: mutant L67R | 著者 | Holden, J.K, Partridge, J.R, Wibowo, A.S, Mulichak, A. | 登録日 | 2023-05-16 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15, 2024
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8T9A
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![BU of 8t9a by Molmil](/molmil-images/mine/8t9a) | CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 | 分子名称: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, Melanoma-associated antigen 3 | 著者 | Duda, D, Righetto, G, Li, Y, Loppnau, P, Seitova, A, Santhakumar, V, Halabelian, L, Yin, Y. | 登録日 | 2023-06-23 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 To Be Published
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8TNR
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![BU of 8tnr by Molmil](/molmil-images/mine/8tnr) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNQ
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![BU of 8tnq by Molmil](/molmil-images/mine/8tnq) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNP
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![BU of 8tnp by Molmil](/molmil-images/mine/8tnp) | Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8SSW
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![BU of 8ssw by Molmil](/molmil-images/mine/8ssw) | |
8U4U
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![BU of 8u4u by Molmil](/molmil-images/mine/8u4u) | |
8UX1
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![BU of 8ux1 by Molmil](/molmil-images/mine/8ux1) | |
8UJY
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![BU of 8ujy by Molmil](/molmil-images/mine/8ujy) | Crystal structure of human WD repeat-containing protein 5 in complex with 4-(3,5-dimethoxybenzyl)-9-(4-fluoro-2-methylphenyl)-7-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (compound 8) | 分子名称: | (9P)-4-[(3,5-dimethoxyphenyl)methyl]-9-(4-fluoro-2-methylphenyl)-7-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-3,4-dihydro-1,4-benzoxazepin-5(2H)-one, WD repeat-containing protein 5 | 著者 | Zhao, B, Amporndanai, K, Fesik, S.W. | 登録日 | 2023-10-11 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors. J.Med.Chem., 66, 2023
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8U16
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![BU of 8u16 by Molmil](/molmil-images/mine/8u16) | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide | 分子名称: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | 著者 | Clifton, M.C, Ma, X, Ornelas, E. | 登録日 | 2023-08-30 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
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8U15
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![BU of 8u15 by Molmil](/molmil-images/mine/8u15) | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220 | 分子名称: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ... | 著者 | Clifton, M.C, Ma, X, Ornelas, E. | 登録日 | 2023-08-30 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
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8WY7
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![BU of 8wy7 by Molmil](/molmil-images/mine/8wy7) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 22 | 分子名称: | 2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide, Bromodomain-containing protein 4 | 著者 | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | 登録日 | 2023-10-30 | 公開日 | 2024-01-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8WA8
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![BU of 8wa8 by Molmil](/molmil-images/mine/8wa8) | Human transketolase in complex with phosphite | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, PHOSPHITE ION, ... | 著者 | Liu, Z, Tittmann, K, Dai, S. | 登録日 | 2023-09-07 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis Acs Catalysis, 14, 2024
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8X72
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![BU of 8x72 by Molmil](/molmil-images/mine/8x72) | The Crystal Structure of PLK1 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Wu, B. | 登録日 | 2023-11-22 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Crystal Structure of PLK1 from Biortus. To Be Published
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8WQR
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![BU of 8wqr by Molmil](/molmil-images/mine/8wqr) | Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation | 分子名称: | Activating molecule in BECN1-regulated autophagy protein 1, DNA damage-binding protein 1 | 著者 | Liu, M, Wang, Y, Su, M.Y, Stjepanovic, G. | 登録日 | 2023-10-12 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation. Nat Commun, 14, 2023
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8WA9
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![BU of 8wa9 by Molmil](/molmil-images/mine/8wa9) | Human transketolase soaked with donor ketose D-fructose | 分子名称: | 1,2-ETHANEDIOL, 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ... | 著者 | Liu, Z, Tittmann, K, Dai, S. | 登録日 | 2023-09-07 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis Acs Catalysis, 14, 2024
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8WY3
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![BU of 8wy3 by Molmil](/molmil-images/mine/8wy3) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 21 | 分子名称: | Bromodomain-containing protein 4, ~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide | 著者 | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | 登録日 | 2023-10-30 | 公開日 | 2024-01-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8WAA
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![BU of 8waa by Molmil](/molmil-images/mine/8waa) | Human transketolase soaked with donor ketose D-xylulose | 分子名称: | 1,2-ETHANEDIOL, 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ... | 著者 | Liu, Z, Dai, S, Tittmann, K. | 登録日 | 2023-09-07 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis Acs Catalysis, 14, 2024
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8WXY
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![BU of 8wxy by Molmil](/molmil-images/mine/8wxy) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 23 | 分子名称: | 5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-4-[(2-morpholin-4-yl-2-oxidanylidene-ethyl)amino]pyridin-2-one, Bromodomain-containing protein 4, GLYCEROL | 著者 | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | 登録日 | 2023-10-30 | 公開日 | 2024-01-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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