6SIW
 
 | | PaaK family AMP-ligase with AMP | | 分子名称: | 1,2-ETHANEDIOL, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ADENOSINE MONOPHOSPHATE, ... | | 著者 | Naismith, J.H, Song, H. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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3DV9
 | | Putative beta-phosphoglucomutase from Bacteroides vulgatus. | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Osipiuk, J, Tesar, C, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2008-07-18 | | 公開日 | 2008-08-05 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | X-ray crystal structure of putative beta-phosphoglucomutase from Bacteroides vulgatus.
To be Published
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5NC9
 | | Crystal structure of the polysaccharide deacetylase Bc1974 from Bacillus cereus in complex with (2S)-2,6-diamino-N-hydroxyhexanamide | | 分子名称: | (2~{S})-2,6-bis(azanyl)-~{N}-oxidanyl-hexanamide, 1,2-ETHANEDIOL, CITRIC ACID, ... | | 著者 | Giastas, P, Andreou, A, Eliopoulos, E.E. | | 登録日 | 2017-03-03 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors.
Biochemistry, 57, 2018
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6RU4
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4OCA
 | | Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N | | 分子名称: | (2R,3R,4S,5S)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]tetrahydro-2H-pyr an-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | | 著者 | Sousa, M.C, Lee, M. | | 登録日 | 2014-01-08 | | 公開日 | 2014-03-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative Bacteria.
Biochemistry, 53, 2014
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8JFK
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6S6R
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5H5X
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9CXR
 | | X-ray Crystallographic Structure of the Poly(Hexamethylene Adipamide) (Nylon66) Hydrolase Nyl50 at Room Temperature | | 分子名称: | 1,2-ETHANEDIOL, Poly(hexamethylene adipamide) hydrolase, SODIUM ION, ... | | 著者 | Meilleur, F, Williams, A.N, Drufva, E.E, Parks, J.M, Chen, S.H, Michener, J.K. | | 登録日 | 2024-07-31 | | 公開日 | 2025-01-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identification and characterization of substrate- and product-selective nylon hydrolases.
Biorxiv, 2024
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6INM
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | (1S)-1-[2-(1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | | 登録日 | 2018-10-26 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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3E1X
 | | The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution | | 分子名称: | GLYCEROL, Prostasin | | 著者 | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | | 登録日 | 2008-08-04 | | 公開日 | 2009-05-05 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
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8JJ3
 | | Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 2.5 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHLORIDE ION, Proton-gated ion channel | | 著者 | Bharambe, N, Li, Z, Basak, S. | | 登録日 | 2023-05-29 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.6476 Å) | | 主引用文献 | Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment.
Nat Commun, 15, 2024
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6RGR
 | | Photorhabdus asymbiotica lectin PHL in complex with L-rhamnose | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lectin PHL, ... | | 著者 | Houser, J, Fujdiarova, E, Jancarikova, G, Wimmerova, M. | | 登録日 | 2019-04-17 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Heptabladed beta-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system.
Febs J., 288, 2021
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5NQC
 | | CK2alpha in complex with NMR154 | | 分子名称: | (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CHLORIDE ION, Casein kinase II subunit alpha | | 著者 | Seetoh, W.-G, Stubbs, C.J. | | 登録日 | 2017-04-19 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Disrupting the CK2alpha-CK2beta protein-protein interaction within the protein kinase CK2 heterotetramer using a fragment-based approach
To Be Published
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5NND
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac) | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Histone H3 | | 著者 | Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C. | | 登録日 | 2017-04-08 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
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7CTT
 | | Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. | | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Peng, Q, Peng, R, Shi, Y. | | 登録日 | 2020-08-20 | | 公開日 | 2020-09-02 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir.
Innovation (N Y), 2, 2021
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5NON
 | | Structure of truncated Norcoclaurine Synthase from Thalictrum flavum with product mimic | | 分子名称: | 4-[2-[2-(4-methoxyphenyl)ethylamino]ethyl]benzene-1,2-diol, S-norcoclaurine synthase | | 著者 | Sula, A, Lichman, B.R, Pesnot, T, Ward, J.M, Hailes, H.C, Keep, N.H. | | 登録日 | 2017-04-12 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase.
Biochemistry, 56, 2017
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8DMQ
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8E8L
 | | 9H2 Fab-poliovirus 1 complex | | 分子名称: | 9H2 Fab heavy chain, 9H2 Fab light chain, Capsid protein VP1, ... | | 著者 | Charnesky, A.J. | | 登録日 | 2022-08-25 | | 公開日 | 2023-06-21 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes.
Nat Commun, 14, 2023
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3NEH
 | | Crystal structure of the protein LMO2462 from Listeria monocytogenes complexed with ZN and phosphonate mimic of dipeptide L-Leu-D-Ala | | 分子名称: | (2R)-3-[(R)-[(1R)-1-amino-3-methylbutyl](hydroxy)phosphoryl]-2-methylpropanoic acid, Renal dipeptidase family protein, ZINC ION | | 著者 | Fedorov, A.A, Fedorov, E.V, Cummings, J, Raushel, F.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2010-06-08 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.642 Å) | | 主引用文献 | Crystal structure of the protein LMO2462 from Listeria monocytogenes
complexed with ZN and phosphonate mimic of dipeptide L-Leu-D-Ala
To be Published
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5C2I
 | | Crystal structure of Anabaena sp. DyP-type peroxidese (AnaPX) | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, Alr1585 protein, ... | | 著者 | Yoshida, T, Amano, Y, Tsuge, H, Sugano, Y. | | 登録日 | 2015-06-16 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Anabaena sp. DyP-type peroxidase is a tetramer consisting of two asymmetric dimers.
Proteins, 84, 2016
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6S0I
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6U9R
 | | MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140) | | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | | 著者 | Petrunak, E.M, Stuckey, J.A. | | 登録日 | 2019-09-09 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
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6S6L
 | | Cryo-EM structure of murine norovirus (MNV-1) | | 分子名称: | Capsid protein | | 著者 | Snowden, J.S, Hurdiss, D.L, Adeyemi, O.O, Ranson, N.A, Herod, M.R, Stonehouse, N.J. | | 登録日 | 2019-07-03 | | 公開日 | 2020-05-13 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM.
Plos Biol., 18, 2020
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3G0M
 | | Crystal structure of cysteine desulfuration protein SufE from Salmonella typhimurium LT2 | | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Cysteine desulfuration protein sufE, ... | | 著者 | Nocek, B, Maltseva, N, Stam, J, Anderson, W, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2009-01-28 | | 公開日 | 2009-02-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Crystal structure of cysteine desulfuration protein SufE from Salmonella typhimurium LT2
To be Published
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