PDB: 616 件ウェブページステータス検索Chemie searchBIRD

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6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide 分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide 著者 Schumacher, M.A. 登録日 2017-12-22 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBW	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-II with 14-3-3sigma 分子名称: (2~{R})-2-[(~{S})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-20 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6FCP	Crystal structure of 14-3-3 sigma in complex with Shroom3 P1244L 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Leysen, S, Meijer, F.A, Milroy, L.G, Ottmann, C. 登録日 2017-12-20 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD. J. Am. Soc. Nephrol., 29, 2018
6BYK	Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide 分子名称: 14-3-3 protein beta/alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATPPVSQASSTT O-GlcNac peptide 著者 Schumacher, M.A. 登録日 2017-12-20 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6FBY	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma 分子名称: (2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-20 公開日 2018-05-16 最終更新日 2019-02-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6BYL	Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide 分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSASTTVPVTTATTTTTSTW O-GlcNac peptide 著者 Schumacher, M.A. 登録日 2017-12-20 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6BYJ	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide 分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide 著者 Schumacher, M.A. 登録日 2017-12-20 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6FAW	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2c-I with 14-3-3sigma 分子名称: (2~{R})-2-[(~{R})-[2-(2-methoxyethoxy)phenyl]-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-18 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6FAU	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma 分子名称: (2~{R})-2-[(~{R})-(2-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-18 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6FBB	Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Leysen, S, Meijer, F.A, Milroy, L.G, Ottmann, C. 登録日 2017-12-18 公開日 2018-03-14 最終更新日 2018-05-09 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD. J. Am. Soc. Nephrol., 29, 2018
6FAV	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-I with 14-3-3sigma 分子名称: (2~{R})-2-[(~{R})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-18 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
6BQT	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-11-28 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6F08	14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1) 分子名称: 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1 著者 Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S. 登録日 2017-11-17 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1). J. Struct. Biol., 202, 2018
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide 分子名称: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 著者 Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. 登録日 2017-11-17 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018
5YQG	The structure of 14-3-3 and pNumb peptide 分子名称: 14-3-3 protein eta, Peptide from Protein numb homolog 著者 Chen, X, Liu, Z, Wen, W. 登録日 2017-11-06 公開日 2018-02-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. J. Biol. Chem., 293, 2018
6EWW	Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif 分子名称: 14-3-3 protein zeta/delta, ARG-LYS-LEU-SEP-LEU-GLN-GLU-ARG 著者 Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2017-11-06 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.679 Å) 主引用文献 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862, 2018
6BCR	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.986 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6BD1	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366 分子名称: 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, Insulin receptor substrate protein of 53 kDa, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6BD2	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6BCY	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T360 分子名称: 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6EJL	Structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif 分子名称: 14-3-3 protein zeta/delta, Mitogen-activated protein kinase kinase kinase 5 著者 Petrvalska, O, Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2017-09-21 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.382 Å) 主引用文献 Crystal structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif To Be Published
6EIH	The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide 分子名称: 14-3-3 protein epsilon, SER-ILE-SEP-ARG 著者 Akutsu, M, Wagner, S.A, Beli, P. 登録日 2017-09-19 公開日 2018-02-14 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun, 9, 2018
5OM0	CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640 分子名称: 14-3-3 protein sigma,Zinc finger protein GLI1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-28 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
5OMA	CH3 chimera of human 14-3-3 sigma with the StARD1 peptide including Ser57 分子名称: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-28 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017
5OK9	CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with swapped phosphopeptides 分子名称: 14-3-3 protein sigma,Heat shock protein beta-6, DI(HYDROXYETHYL)ETHER 著者 Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A. 登録日 2017-07-25 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep, 7, 2017

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