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5ZKQ
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Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ...
著者Cao, C, Zhao, Q, Zhang, X.C, Wu, B.
登録日2018-03-25
公開日2018-06-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
4XEE
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BU of 4xee by Molmil
Structure of active-like neurotensin receptor
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ...
著者Krumm, B.E, White, J.F, Shah, P, Grisshammer, R.
登録日2014-12-23
公開日2015-07-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural prerequisites for G-protein activation by the neurotensin receptor.
Nat Commun, 6, 2015
6OS0
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Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen, CHLORIDE ION, ...
著者Wingler, L.M, Staus, D.P, Skiba, M.A, McMahon, C, Kleinhenz, A.L.W, Lefkowitz, R.J, Kruse, A.C.
登録日2019-05-01
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Science, 367, 2020
8TLM
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BU of 8tlm by Molmil
Structure of a class A GPCR/Fab complex
分子名称: C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ...
著者Sun, D, Johnson, M, Masureel, M.
登録日2023-07-27
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
8HK2
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C3aR-Gi-C3a protein complex
分子名称: C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ...
著者Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E.
登録日2022-11-24
公開日2023-05-10
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
7VKT
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BU of 7vkt by Molmil
cryo-EM structure of LTB4-bound BLT1 in complex with Gi protein
分子名称: CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者He, Y, Wang, N.
登録日2021-10-01
公開日2022-03-09
最終更新日2022-03-23
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of leukotriene B4 receptor 1 activation.
Nat Commun, 13, 2022
5TVN
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Crystal structure of the LSD-bound 5-HT2B receptor
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ...
著者Wacker, D, Wang, S, McCorvy, J.D, Betz, R.M, Venkatakrishnan, A.J, Levit, A, Lansu, K, Schools, Z.L, Che, T, Nichols, D.E, Shoichet, B.K, Dror, R.O, Roth, B.L.
登録日2016-11-09
公開日2017-02-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Cell, 168, 2017
7VL8
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Cryo-EM structure of the Apo CCR1-Gi complex
分子名称: C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H.
登録日2021-10-02
公開日2022-03-23
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
7VDH
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2
分子名称: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Li, Y, Yang, F.
登録日2021-09-07
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
8PKM
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Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
分子名称: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone, 5-hydroxytryptamine receptor 1A, ...
著者Schneider, J, Gmeiner, P, Hove, T.T, Rasmussen, T, Boettcher, B.
登録日2023-06-27
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Discovery of a functionally selective serotonin 1A receptor agonist for the treatment of pain
To Be Published
7E33
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BU of 7e33 by Molmil
Serotonin 1E (5-HT1E) receptor-Gi protein complex
分子名称: 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
登録日2021-02-07
公開日2021-04-14
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7E32
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Serotonin 1D (5-HT1D) receptor-Gi protein complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
登録日2021-02-07
公開日2021-04-21
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7Y15
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BU of 7y15 by Molmil
Cryo-EM structure of apo-state MrgD-Gi complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
8GG0
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BU of 8gg0 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
7SRR
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BU of 7srr by Molmil
5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)
分子名称: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ...
著者Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G.
登録日2021-11-08
公開日2022-09-21
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
Neuron, 110, 2022
4BEY
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BU of 4bey by Molmil
Night blindness causing G90D rhodopsin in complex with GaCT2 peptide
分子名称: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
著者Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J.
登録日2013-03-12
公開日2013-05-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin.
Embo Rep., 14, 2013
7W56
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BU of 7w56 by Molmil
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者You, C, Xu, H.E, Jiang, Y.
登録日2021-11-29
公開日2022-04-20
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
7Y64
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Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
分子名称: C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
7Y66
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Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein
分子名称: BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
8WC8
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Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex
分子名称: 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日2023-09-11
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
4DJH
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Structure of the human kappa opioid receptor in complex with JDTic
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CITRIC ACID, ...
著者Wu, H, Wacker, D, Katritch, V, Mileni, M, Han, G.W, Vardy, E, Liu, W, Thompson, A.A, Huang, X.P, Carroll, F.I, Mascarella, S.W, Westkaemper, R.B, Mosier, P.D, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
登録日2012-02-01
公開日2012-03-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献tructure of the human kappa-opioid receptor in complex with JDTic
Nature, 485, 2012
7JVP
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BU of 7jvp by Molmil
Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
分子名称: (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
登録日2020-08-22
公開日2021-02-24
最終更新日2021-03-03
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
6K41
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BU of 6k41 by Molmil
cryo-EM structure of alpha2BAR-GoA complex
分子名称: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K.
登録日2019-05-23
公開日2020-04-15
最終更新日2020-05-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine.
Nat.Chem.Biol., 16, 2020
5WF6
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Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Human A2a adenosine receptor T4L chimera
著者White, K.L, Eddy, M.T, Gao, Z, Han, G.W, Hanson, M.A, Lian, T, Deary, A, Patel, N, Jacobson, K.A, Katritch, V, Stevens, R.C.
登録日2017-07-11
公開日2018-02-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.
Structure, 26, 2018
7XXH
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Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11
分子名称: 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B.
登録日2022-05-30
公開日2023-06-07
最終更新日2023-09-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023

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