1KHG
| PEPCK | 分子名称: | 1,2-ETHANEDIOL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... | 著者 | Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. | 登録日 | 2001-11-29 | 公開日 | 2002-02-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
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1M51
| PEPCK complex with a GTP-competitive inhibitor | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ... | 著者 | Foley, L.H, Wang, P, Dunten, P, Wertheimer, S.J. | 登録日 | 2002-07-06 | 公開日 | 2003-09-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
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6SOX
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-carbamoylbenzoic acid | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-aminocarbonylbenzoic acid, DIMETHYL SULFOXIDE, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-08-30 | 公開日 | 2020-09-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SNX
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with benzamide | 分子名称: | BENZAMIDE, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-08-27 | 公開日 | 2020-09-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SPY
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 6-(morpholin-4-yl)pyridine-3-carboxamide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 6-morpholin-4-ylpyridine-3-carboxamide, DIMETHYL SULFOXIDE, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-03 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SNN
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with benzoic acid | 分子名称: | BENZOIC ACID, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Oebbeke, M, Merkl, S, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-08-27 | 公開日 | 2020-09-09 | 最終更新日 | 2020-12-30 | 実験手法 | X-RAY DIFFRACTION (1.817 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SPM
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-(trifluoromethyl)benzoic acid | 分子名称: | 4-(trifluoromethyl)benzoic acid, DIMETHYL SULFOXIDE, METHANOL, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-02 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SPU
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 3-aminobenzoic acid | 分子名称: | 3-AMINOBENZOIC ACID, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-02 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6SQ1
| Crystal structure of cAMP-dependent Protein Kinase A (CHO PKA) in complex with Aminofasudil | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine, DIMETHYL SULFOXIDE, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-03 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | A crystallographic study of cAMP-dependent Protein Kinase A in complex with different Fasudil-derivatives To Be Published
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6SPS
| Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-(trifluoromethyl)benzamide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(trifluoromethyl)benzamide, DIMETHYL SULFOXIDE, ... | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | 登録日 | 2019-09-02 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
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6U4S
| wild type cysteine dioxygenase | 分子名称: | Cysteine dioxygenase type 1, FE (III) ION | 著者 | Meneely, K.M, Chilton, A.S, Forbes, D.L, Ellis, H.R, Lamb, A.L. | 登録日 | 2019-08-26 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase. Biochemistry, 59, 2020
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6U1M
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6U4L
| cysteine dioxygenase variant - C93E | 分子名称: | ACETATE ION, Cysteine dioxygenase type 1, FE (III) ION | 著者 | Meneely, K.M, Chilton, A.S, Forbes, D.L, Ellis, H.R, Lamb, A.L. | 登録日 | 2019-08-26 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.911 Å) | 主引用文献 | The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase. Biochemistry, 59, 2020
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6UJT
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6UJR
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6UJW
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6MM5
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6MM7
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6MM6
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6MM8
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6N43
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6NIY
| A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex | 分子名称: | Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M. | 登録日 | 2019-01-02 | 公開日 | 2019-01-23 | 最終更新日 | 2020-04-08 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | The Molecular Control of Calcitonin Receptor Signaling. Acs Pharmacol Transl Sci, 2, 2019
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6NI3
| B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex | 分子名称: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Endolysin,Beta-2 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Nguyen, A.H, Thomsen, A.R.B, Cahill, T.J, des Georges, A, Lefkowitz, R.J. | 登録日 | 2018-12-26 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex. Nat.Struct.Mol.Biol., 26, 2019
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6NO7
| Crystal Structure of the full-length wild-type PKA RIa Holoenzyme | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Lu, T, Wu, J, Taylor, S.S. | 登録日 | 2019-01-15 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | Two PKA RI alpha holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc.Natl.Acad.Sci.USA, 116, 2019
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6M1H
| CryoEM structure of human PAC1 receptor in complex with maxadilan | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. | 登録日 | 2020-02-26 | 公開日 | 2020-03-11 | 最終更新日 | 2020-05-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
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