PDB: 7755 件ウェブページステータス検索Chemie searchBIRD

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8PUI	human PHOX2B C-terminal domain including the polyA fragment at 298K 分子名称: Paired mesoderm homeobox protein 2B 著者 Anton, R, Trevino, M.A, Pantoja-Uceda, D, Felix, S, Babu, M, Cabrita, E.J, Zweckstetter, M, Tinnefeld, P, Vera, A.M, Oroz, J. 登録日 2023-07-17 公開日 2024-03-13 実験手法 SOLUTION NMR 主引用文献 Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions. Nat Commun, 15, 2024
8PTL	human PHOX2B C-terminal domain including the polyA fragment at 278K 分子名称: Paired mesoderm homeobox protein 2B 著者 Anton, R, Trevino, M.A, Pantoja-Uceda, D, Felix, S, Babu, M, Cabrita, E.J, Zweckstetter, M, Tinnefeld, P, Vera, A.M, Oroz, J. 登録日 2023-07-14 公開日 2024-03-13 実験手法 SOLUTION NMR 主引用文献 Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions. Nat Commun, 15, 2024
4EFR	Bombyx mori lipoprotein 7 (crystal form II) at 2.50 A resolution 分子名称: 30kDa protein, THIOCYANATE ION 著者 Pietrzyk, A.J, Panjikar, S, Bujacz, A, Mueller-Dieckmann, J, Jaskolski, M, Bujacz, G. 登録日 2012-03-30 公開日 2012-08-29 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 High-resolution structure of Bombyx mori lipoprotein 7: crystallographic determination of the identity of the protein and its potential role in detoxification. Acta Crystallogr.,Sect.D, 68, 2012
8AR7	Bovine glutamate dehydrogenase in ternary complex with the allosteric activators ADP and leucine 分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutamate dehydrogenase (NAD(P)(+)), LEUCINE, ... 著者 Aleshin, V.A, Bellinzoni, M. 登録日 2022-08-15 公開日 2022-10-05 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.448 Å) 主引用文献 Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase. Int J Mol Sci, 23, 2022
2HPQ	Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin 分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ... 著者 Tulinsky, A, Padmanabhan, K. 登録日 1993-04-28 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. Biochemistry, 32, 1993
2HPP	Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin 分子名称: ALPHA-THROMBIN HEAVY CHAIN, ALPHA-THROMBIN LIGHT CHAIN, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ... 著者 Tulinsky, A, Padmanabhan, K. 登録日 1993-04-28 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. Biochemistry, 32, 1993
8AB3	Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in complex with oxamate, NADH and FBP. 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,6-di-O-phosphono-beta-D-fructofuranose, L-lactate dehydrogenase, ... 著者 Robin, A.Y, Girard, E, Madern, D. 登録日 2022-07-04 公開日 2022-07-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.616 Å) 主引用文献 Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery. Mol.Biol.Evol., 40, 2023
4EQK	Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, NITRATE ION, Polymerase basic protein 2 著者 Meng, G, Liu, Y, Zheng, X. 登録日 2012-04-19 公開日 2013-03-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus J.Biol.Chem., 288, 2013
4ENF	Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1) 分子名称: 1,4-BUTANEDIOL, NITRATE ION, Polymerase basic protein 2 著者 Meng, G, Liu, Y, Zheng, X. 登録日 2012-04-13 公開日 2013-03-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus J.Biol.Chem., 288, 2013
4CFZ	SAVINASE CRYSTAL STRUCTURES FOR COMBINED SINGLE CRYSTAL DIFFRACTION AND POWDER DIFFRACTION ANALYSIS 分子名称: CALCIUM ION, SODIUM ION, SUBTILISIN SAVINASE, ... 著者 Frankaer, C.G, Moroz, O.V, Turkenburg, J.P, Aspmo, S.I, Thymark, M, Friis, E.P, Stahla, K, Nielsen, J.E, Wilson, K.S, Harris, P. 登録日 2013-11-19 公開日 2014-04-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Analysis of an Industrial Production Suspension of Bacillus Lentus Subtilisin Crystals by Powder Diffraction: A Powerful Quality-Control Tool. Acta Crystallogr.,Sect.D, 70, 2014
4D1J	The structure of the GH35 beta-galactosidase Bgl35A from Cellvibrio japonicas in complex with 1-Deoxygalactonojirimycin 分子名称: (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, ACETATE ION, BETA-GALACTOSIDASE, ... 著者 Larsbrink, J, Thompson, A.J, Lundqvist, M, Gardner, J.G, Davies, G.J, Brumer, H. 登録日 2014-05-02 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A Complex Gene Locus Enables Xyloglucan Utilization in the Model Saprophyte Cellvibrio Japonicus. Mol.Microbiol., 94, 2014
8B0X	Translating 70S ribosome in the unrotated state (P and E, tRNAs) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Fromm, S.A, O'Connor, K.M, Purdy, M, Bhatt, P.R, Loughran, G, Atkins, J.F, Jomaa, A, Mattei, S. 登録日 2022-09-08 公開日 2022-11-30 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (1.55 Å) 主引用文献 The translating bacterial ribosome at 1.55 angstrom resolution generated by cryo-EM imaging services. Nat Commun, 14, 2023
4MQL	Crystal structure of Antigen 85C-C209S mutant 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Diacylglycerol acyltransferase/mycolyltransferase Ag85C 著者 Favrot, L, Grzegorzewicz, A.E, Lajiness, D.H, Marvin, R.K, Boucau, J, Isailovic, D, Jackson, M, Ronning, D.R. 登録日 2013-09-16 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun, 4, 2013
4EON	Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306 分子名称: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
8AHW	Structure of DCS-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis 分子名称: 1,2-ETHANEDIOL, Alanine racemase, GLYCEROL 著者 de Chiara, C, Prosser, G, Ogrodowicz, R.W, de Carvalho, L.P.S. 登録日 2022-07-22 公開日 2023-04-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis . Acs Bio Med Chem Au, 3, 2023
4EOR	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102 分子名称: Cyclin-A2, Cyclin-dependent kinase 2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE 著者 Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. 登録日 2012-04-14 公開日 2013-02-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
3NYS	X-ray structure of the K185A mutant of WbpE (WlbE) from pseudomonas aeruginosa in complex with PLP at 1.45 angstrom resolution 分子名称: Aminotransferase WbpE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION 著者 Holden, H.M, Thoden, J.B. 登録日 2010-07-15 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase. Protein Sci., 26, 2017
4MTT	Ni- and Zn-bound GloA2 at low resolution 分子名称: CHLORIDE ION, GLYCEROL, Lactoylglutathione lyase, ... 著者 Bythell-Douglas, R, Bond, C.S. 登録日 2013-09-20 公開日 2014-09-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 The crystal structure of a homodimeric Pseudomonas glyoxalase I enzyme reveals asymmetric metallation commensurate with half-of-sites activity. Chemistry, 21, 2015
4MYQ	Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33 分子名称: (4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid, 1,2-ETHANEDIOL, MAGNESIUM ION, ... 著者 Fox III, D, Edwards, T.E. 登録日 2013-09-27 公開日 2014-01-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cell Signal, 26, 2014
1TVR	HIV-1 RT/9-CL TIBO 分子名称: 4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE, REVERSE TRANSCRIPTASE 著者 Das, K, Ding, J, Hsiou, Y, Arnold, E. 登録日 1996-04-16 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J.Mol.Biol., 264, 1996
1UCY	THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A ALPHA (RESIDUES 7-19). THREE COMPLEXES, ONE WITH EPSILON-THROMBIN AND TWO WITH ALPHA-THROMBIN 分子名称: FIBRINOPEPTIDE A-ALPHA, THROMBIN 著者 Martin, P, Edwards, B. 登録日 1996-08-30 公開日 1997-02-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues. Biochemistry, 35, 1996
8Q68	Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143 分子名称: Transcriptional enhancer factor TEF-1, ~{N}-[(3~{S})-5-azanyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2~{H}-quinolin-3-yl]propanamide 著者 Ciesielski, F, Spieser, S.A.H, Marchand, A, Gwaltney, S.L. 登録日 2023-08-11 公開日 2023-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models. Mol.Cancer Ther., 23, 2024
4D8I	High resolution structures of monomeric S. pyogenes SpeB reveals role of glycine-rich active site loop 分子名称: ACE-AEIK-CHO ALDEHYDE (BOUND FORM), NITRATE ION, Streptopain 著者 Gonzalez, G.E, Wolan, D.W. 登録日 2012-01-10 公開日 2012-06-06 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop. J.Biol.Chem., 287, 2012
4D9R	Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D 分子名称: CHLORIDE ION, Complement factor D, Fab heavy chain, ... 著者 Murray, J.M, Wiesmann, C. 登録日 2012-01-11 公開日 2012-02-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Inhibiting alternative pathway complement activation by targeting the factor d exosite. J.Biol.Chem., 287, 2012
4D9Q	Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D 分子名称: Anti-Factor D, heavy chain, light chain, ... 著者 Murray, J.M, Wiesmann, C. 登録日 2012-01-11 公開日 2012-02-22 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Inhibiting alternative pathway complement activation by targeting the factor d exosite. J.Biol.Chem., 287, 2012

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