PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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3MWJ	Q28E mutant of HERA N-terminal RecA-like domain, apo form 分子名称: Heat resistant RNA dependent ATPase, SULFATE ION 著者 Rudolph, M.G, Klostermeier, D. 登録日 2010-05-06 公開日 2011-03-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop. Biol.Chem., 392, 2011
7CI4	Crystal structure of P.aeruginosa LpxC in complex with inhibitor 分子名称: (2R)-2-azanyl-4-methylsulfonyl-N-[3-(trifluoromethyloxy)phenyl]butanamide, CHLORIDE ION, MAGNESIUM ION, ... 著者 Mima, M, Baker, L.M, Surgenor, A, Robertson, A. 登録日 2020-07-07 公開日 2020-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63, 2020
7CIC	Crystal structure of P.aeruginosa LpxC in complex with inhibitor 分子名称: 2-azanyl-N-[3-(trifluoromethyloxy)phenyl]ethanamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION 著者 Baker, L.M, Mima, M, Surgenor, A, Robertson, A. 登録日 2020-07-07 公開日 2020-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63, 2020
5GWS	4-hydroxyisoleucine dehydrogenase complexed with NADH and succinate 分子名称: 4-hydroxyisolecuine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SUCCINIC ACID 著者 Shi, X, Miyakawa, T, Nakamura, A, Tanokura, M. 登録日 2016-09-13 公開日 2017-10-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers. Sci Rep, 7, 2017
5GWR	4-hydroxyisoleucine dehydrogenase complexed with NADH 分子名称: 1,2-ETHANEDIOL, 4-hydroxyisolecuine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Shi, X, Miyakawa, T, Nakamura, A, Tanokura, M. 登録日 2016-09-13 公開日 2017-10-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers Sci Rep, 7, 2017
7C3N	Crystal structure of JAK3 in complex with Delgocitinib 分子名称: 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile, Tyrosine-protein kinase JAK3 著者 Doi, S, Otira, T, Kikuwaka, M, Nomura, A, Noji, S, Adachi, T. 登録日 2020-05-13 公開日 2020-06-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders. J.Med.Chem., 63, 2020
3DX1	Golgi alpha-Mannosidase II in complex with Mannostatin analog (1S,2S,3R,4R)-4-aminocyclopentane-1,2,3-triol 分子名称: (1S,2S,3R,4R)-4-aminocyclopentane-1,2,3-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2008-07-23 公開日 2009-07-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem, 10, 2009
4YNY	Crystal structure of monoclonal anti-human podoplanin antibody NZ-1 分子名称: Heavy chain of antigen binding fragment, Fab, Light chain of antigen binding fragment 著者 Fujii, Y, Kitago, Y, Arimori, T, Takagi, J. 登録日 2015-03-11 公開日 2016-03-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.584 Å) 主引用文献 Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state J.Cell.Sci., 129, 2016
7BRN	Crystal structure of Atg40 AIM fused to Atg8 分子名称: 1,2-ETHANEDIOL, Autophagy-related protein 40,Autophagy-related protein 8, L-EPINEPHRINE 著者 Yamasaki, A, Noda, N.N. 登録日 2020-03-29 公開日 2020-07-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.231 Å) 主引用文献 Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes. Nat Commun, 11, 2020
3DX4	Golgi alpha-Mannosidase II in complex with Mannostatin analog (1R,2R,3R,4S,5R)-4-amino-5-methoxycyclopentane-1,2,3-triol 分子名称: (1R,2R,3R,4S,5R)-4-amino-5-methoxycyclopentane-1,2,3-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2008-07-23 公開日 2009-07-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem, 10, 2009
5ZH3	CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6 分子名称: (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase 著者 Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. 登録日 2018-03-11 公開日 2018-06-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
7CI9	Crystal structure of P.aeruginosa LpxC in complex with inhibitor 分子名称: 1,2-ETHANEDIOL, 2-azanyl-2-[[4-[2-[3-[[2-[(1S)-1-oxidanylethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]ethynyl]phenoxy]methyl]propane-1,3-diol, PHOSPHATE ION, ... 著者 Mima, M, Baker, L.M, Surgenor, A, Robertson, A. 登録日 2020-07-07 公開日 2020-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63, 2020
4WJU	Crystal structure of Rsa4 from Saccharomyces cerevisiae 分子名称: GLYCEROL, Ribosome assembly protein 4 著者 Holdermann, I, Bassler, J, Hurt, E, Sinning, I. 登録日 2014-10-01 公開日 2014-11-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
7CI5	Crystal structure of P.aeruginosa LpxC in complex with inhibitor 分子名称: (3R)-3-azanyl-4-oxidanylidene-4-[[3-(trifluoromethyloxy)phenyl]amino]butanoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... 著者 Mima, M, Baker, L.M, Surgenor, A, Robertson, A. 登録日 2020-07-07 公開日 2020-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63, 2020
7CN0	Cryo-EM structure of K+-bound hERG channel 分子名称: POTASSIUM ION, potassium channel 1 著者 Asai, T, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Senda, T, Murata, T. 登録日 2020-07-29 公開日 2021-01-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM Structure of K + -Bound hERG Channel Complexed with the Blocker Astemizole. Structure, 29, 2021
5XM1	The mouse nucleosome structure containing H2A, H2B type3-A, H3mm7, and H4 分子名称: DNA (146-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... 著者 Taguchi, H, Horikoshi, N, Kurumizaka, H. 登録日 2017-05-12 公開日 2018-03-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration. Nat Commun, 9, 2018
3MUG	Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody PG16 Heavy Chain, ... 著者 Pejchal, R, Walker, L.M, Burton, D.R, Wilson, I.A. 登録日 2010-05-03 公開日 2010-06-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc.Natl.Acad.Sci.USA, 107, 2010
3MUH	Crystal structure of PG9 light chain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody PG9 light chain 著者 Pejchal, R, Walker, L.M, Burton, D.R, Wilson, I.A. 登録日 2010-05-03 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc.Natl.Acad.Sci.USA, 107, 2010
5XIO	Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone 分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), ... 著者 Jain, V, Manickam, Y, Sharma, A. 登録日 2017-04-26 公開日 2018-03-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XIJ	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9 分子名称: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Jain, V, Manickam, Y, Sharma, A. 登録日 2017-04-26 公開日 2018-03-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5F9R	Crystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage 分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (30-MER), DNA (5'-D(P*AP*TP*GP*AP*GP*AP*CP*GP*CP*TP*GP*GP*AP*GP*TP*AP*CP*AP*C)-3'), ... 著者 Jiang, F, Doudna, J.A. 登録日 2015-12-10 公開日 2016-01-27 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science, 351, 2016
5XIH	Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5 分子名称: 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ... 著者 Jain, V, Manickam, Y, Sharma, A. 登録日 2017-04-26 公開日 2018-03-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
5XOU	Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 7T8 on the guide strand 分子名称: DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ... 著者 Sheng, G, Wang, J, Zhao, H, Wang, Y. 登録日 2017-05-31 公開日 2017-10-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes Nucleic Acids Res., 45, 2017
4WEK	Crystal structure of Pseudomonas aeruginosa PBP3 with a R4 substituted vinyl monocarbam 分子名称: (3S,4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-3-ethenyl-4-formyl-1-[({3-(5-hydroxy-4-oxo-3,4-dihydropyridin-2-yl)-4-[3-(methylsulfonyl)propyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oic acid, Penicillin-binding protein 3 著者 Ferguson, A.D. 登録日 2014-09-10 公開日 2015-04-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3. Acs Med.Chem.Lett., 6, 2015
3G86	Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor 分子名称: N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Harris, S.F, Ghate, M. 登録日 2009-02-11 公開日 2009-09-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones Bioorg.Med.Chem.Lett., 19, 2009

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