PDB: 454 件ウェブページステータス検索Chemie searchBIRD

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1F2A	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II) 分子名称: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE, CRUZAIN 著者 Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. 登録日 2000-05-23 公開日 2000-07-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F29	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I) 分子名称: 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, CRUZAIN 著者 Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. 登録日 2000-05-23 公開日 2000-07-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1EWP	CRUZAIN BOUND TO MOR-LEU-HPQ 分子名称: CRUZAIN, N-[(3S)-1-fluoro-2-oxo-5-phenylpentan-3-yl]-N~2~-(morpholin-4-ylcarbonyl)-L-leucinamide 著者 Gillmor, S.A. 登録日 2000-04-26 公開日 2000-05-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Chapter 3: X-ray Structures of Complexes of Cruzain with Designed Covalent Inhibitors Enzyme-ligand Interactions, Inhibition and Specificity, 1998
1EWO	THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204 分子名称: CRUZAIN, N-[N'-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC ACID PHENYL ESTER 著者 Brinen, L.S, Gillmor, S.A, Fletterick, R.J. 登録日 2000-04-26 公開日 2003-06-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Cruzain bound to WRR-204 To be Published
1EWM	THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112 分子名称: CRUZAIN, N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-L-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE 著者 Brinen, L.S, Gillmor, S.A, Fletterick, R.J. 登録日 2000-04-26 公開日 2003-06-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Cruzain bound to WRR-112 To be Published
1EWL	CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99 分子名称: CRUZAIN, N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE 著者 Brinen, L.S, Gillmor, S.A, Fletterick, R.J. 登録日 2000-04-26 公開日 2003-06-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Cruzain bound to WRR-99 To be Published
1EF7	CRYSTAL STRUCTURE OF HUMAN CATHEPSIN X 分子名称: CATHEPSIN X 著者 Guncar, G, Klemencic, I, Turk, B, Turk, V, Karaoglanovic-Carmona, A, Juliano, L, Turk, D. 登録日 2000-02-07 公開日 2000-03-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. Structure Fold.Des., 8, 2000
1DEU	CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINE PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVE SITE CYSTEINE 分子名称: PROCATHEPSIN X 著者 Sivaraman, J, Nagler, D.K, Zhang, R, Menard, R, Cygler, M. 登録日 1999-11-15 公開日 2000-02-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine. J.Mol.Biol., 295, 2000
1CVZ	CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR) 分子名称: N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE, PAPAIN 著者 Tsuge, H. 登録日 1999-08-24 公開日 2000-08-30 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex. Biochem.Biophys.Res.Commun., 266, 1999
1CTE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN 分子名称: 2-PYRIDINETHIOL, CATHEPSIN B 著者 Huber, C.P, Jia, Z. 登録日 1995-05-03 公開日 1995-07-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
1CSB	Crystal structure of cathepsin b inhibited with CA030 at 2.1 angstroms resolution: A basis for the design of specific epoxysuccinyl inhibitors 分子名称: CATHEPSIN B heavy chain, CATHEPSIN B light chain, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-isoleucyl-L-proline 著者 Turk, D, Bode, W. 登録日 1994-12-09 公開日 1996-04-03 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors. Biochemistry, 34, 1995
1CS8	CRYSTAL STRUCTURE OF PROCATHEPSIN L 分子名称: HUMAN PROCATHEPSIN L 著者 Cygler, M, Coulombe, R. 登録日 1999-08-17 公開日 1999-08-23 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. EMBO J., 15, 1996
1CQD	THE 2.1 ANGSTROM STRUCTURE OF A CYSTEINE PROTEASE WITH PROLINE SPECIFICITY FROM GINGER RHIZOME, ZINGIBER OFFICINALE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (PROTEASE II), ... 著者 Choi, K.H, Laursen, R.A, Allen, K.N. 登録日 1999-06-15 公開日 1999-09-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The 2.1 A structure of a cysteine protease with proline specificity from ginger rhizome, Zingiber officinale. Biochemistry, 38, 1999
1CPJ	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN 分子名称: CATHEPSIN B 著者 Huber, C.P, Jia, Z. 登録日 1995-07-17 公開日 1995-12-07 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
1CJL	CRYSTAL STRUCTURE OF A CYSTEINE PROTEASE PROFORM 分子名称: PROCATHEPSIN L 著者 Coulombe, R, Grochulski, P, Sivaraman, J, Cygler, M. 登録日 1996-07-24 公開日 1997-08-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. EMBO J., 15, 1996
1BY8	THE CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN K 分子名称: PROTEIN (PROCATHEPSIN K) 著者 Lalonde, J.M, Zhao, B, Smith, W.W, Janson, C.A, Desjarlais, R.L, Tomaszek, T.A, Carr, T.J, Thompson, S.K, Yamashita, D.S, Veber, D.F, Abdel-Mequid, S.S. 登録日 1998-10-27 公開日 1999-10-24 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The crystal structure of human procathepsin K. Biochemistry, 38, 1999
1BQI	USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES. 分子名称: CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE, PAPAIN 著者 Lalonde, J.M, Zhao, B, Smith, W.W, Janson, C.A, Desjarlais, R.L, Tomaszek, T.A, Carr, T.J, Thompson, S.K, Yamashita, D.S, Veber, D.F, Abdel-Mequid, S.S. 登録日 1998-08-16 公開日 1999-08-16 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites. J.Med.Chem., 41, 1998
1BP4	USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES. 分子名称: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide, PAPAIN 著者 Lalonde, J.M, Zhao, B, Smith, W.W, Janson, C.A, Desjarlais, R.L, Tomaszek, T.A, Carr, T.J, Thompson, S.K, Yamashita, D.S, Veber, D.F, Abdel-Mequid, S.S. 登録日 1998-08-12 公開日 1999-08-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites. J.Med.Chem., 41, 1998
1BGO	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR 分子名称: 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE, CATHEPSIN K 著者 Desjarlais, R.L, Yamashita, D.S, Oh, H.-J, Bondinell, W.E, Uzinskas, I.N, Erhard, K.F, Allen, A.C, Haltiwanger, R.C, Zhao, B, Smith, W.W, Abdel-Meguid, S.S, D'Alessio, K, Janson, C.A, Mcqueney, M.S, Tomaszek, T.A, Levy, M.A, Veber, D.F. 登録日 1998-05-29 公開日 1999-06-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K J.Am.Chem.Soc., 120, 1998
1AYW	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT BENZYLOXYBENZOYLCARBOHYDRAZIDE INHIBITOR 分子名称: 1-(N-BENZYLOXYCARBONYL-L-LEUCINYL)-5-(3-BENZYLOXY BENZOYL)CARBOHYDRAZIDE, CATHEPSIN K 著者 Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. 登録日 1997-11-10 公開日 1998-11-25 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design of potent and selective human cathepsin K inhibitors that span the active site. Proc.Natl.Acad.Sci.USA, 94, 1997
1AYV	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT THIAZOLHYDRAZIDE INHIBITOR 分子名称: CATHEPSIN K, N-[2-[1-(N-BENZYLOXYCARBONYLAMINO)-3-METHYLBUTYL]THIAZOL-4-YLCARBONYL]-N'-(BENZYLOXYCARBONYL-L-LEUCINYL)HYDRAZIDE 著者 Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. 登録日 1997-11-10 公開日 1998-11-25 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design of potent and selective human cathepsin K inhibitors that span the active site. Proc.Natl.Acad.Sci.USA, 94, 1997
1AYU	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC BISCARBOHYDRAZIDE INHIBITOR 分子名称: 1,5-BIS(N-BENZYLOXYCARBONYL-L-LEUCINYL)CARBOHYDRAZIDE, CATHEPSIN K 著者 Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. 登録日 1997-11-10 公開日 1998-11-25 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design of potent and selective human cathepsin K inhibitors that span the active site. Proc.Natl.Acad.Sci.USA, 94, 1997
1AU4	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR 分子名称: 4-[[N-[(PHENYLMETHOXY)CARBONYL]-/NL/N-LEUCYL]AMINO]-1[(2S)-2-[[[4-(PYRIDINYLMETHOXY)CARBONYL]AMINO]-4-METHYLPENT/NYL]-3-PYRROLIDINONE/N, CATHEPSIN K 著者 Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. 登録日 1997-09-10 公開日 1998-10-14 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J.Med.Chem., 41, 1998
1AU3	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR 分子名称: 1-[N[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-4-[[N/N-[(PHENYLMETHOXY)CARBONYL]-/NL-LEUCYL]AMINO]-3-PYRROLIDINONE/N, CATHEPSIN K 著者 Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. 登録日 1997-09-10 公開日 1998-10-14 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J.Med.Chem., 41, 1998
1AU2	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PROPANONE INHIBITOR 分子名称: 1-[[(4-PHENOXYPHENYL)SULFONYL]AMINO]-3-[[N/N-(4-PYRIDINYLCARBONYL)-L-LEUCYL]AMINO]-2-PROPANOL, CATHEPSIN K 著者 Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. 登録日 1997-09-10 公開日 1998-10-14 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and Design of Potent and Selective Cathepsin K Inhibitors J.Am.Chem.Soc., 119, 1997

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