1BP4

USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.

Summary for 1BP4

Entry DOI	10.2210/pdb1bp4/pdb
Related PRD ID	PRD_001210
Descriptor	PAPAIN, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide (3 entities in total)
Functional Keywords	hydrolase, sulfhydryl proteinase
Biological source	Carica papaya (papaya)
Total number of polymer chains	1
Total formula weight	23926.98
Authors	Lalonde, J.M.,Zhao, B.,Smith, W.W.,Janson, C.A.,Desjarlais, R.L.,Tomaszek, T.A.,Carr, T.J.,Thompson, S.K.,Yamashita, D.S.,Veber, D.F.,Abdel-Mequid, S.S. (deposition date: 1998-08-12, release date: 1999-08-12, Last modification date: 2023-08-09)
Primary citation	LaLonde, J.M.,Zhao, B.,Smith, W.W.,Janson, C.A.,DesJarlais, R.L.,Tomaszek, T.A.,Carr, T.J.,Thompson, S.K.,Oh, H.J.,Yamashita, D.S.,Veber, D.F.,Abdel-Meguid, S.S. Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites. J.Med.Chem., 41:4567-4576, 1998 Cited by PubMed: 9804696 DOI: 10.1021/jm980249f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation