1AYW

CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT BENZYLOXYBENZOYLCARBOHYDRAZIDE INHIBITOR

Summary for 1AYW

Entry DOI	10.2210/pdb1ayw/pdb
Descriptor	CATHEPSIN K, 1-(N-BENZYLOXYCARBONYL-L-LEUCINYL)-5-(3-BENZYLOXY BENZOYL)CARBOHYDRAZIDE (3 entities in total)
Functional Keywords	hydrolase, sulfhydryl proteinase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	24071.08
Authors	Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1997-11-10, release date: 1998-11-25, Last modification date: 2023-08-02)
Primary citation	Thompson, S.K.,Halbert, S.M.,Bossard, M.J.,Tomaszek, T.A.,Levy, M.A.,Zhao, B.,Smith, W.W.,Abdel-Meguid, S.S.,Janson, C.A.,D'Alessio, K.J.,McQueney, M.S.,Amegadzie, B.Y.,Hanning, C.R.,DesJarlais, R.L.,Briand, J.,Sarkar, S.K.,Huddleston, M.J.,Ijames, C.F.,Carr, S.A.,Garnes, K.T.,Shu, A.,Heys, J.R.,Bradbeer, J.,Zembryki, D.,Lee-Rykaczewski, L.,James, I.E.,Lark, M.W.,Drake, F.H.,Gowen, M.,Gleason, J.G.,Veber, D.F. Design of potent and selective human cathepsin K inhibitors that span the active site. Proc.Natl.Acad.Sci.USA, 94:14249-14254, 1997 Cited by PubMed: 9405598 DOI: 10.1073/pnas.94.26.14249 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation