2XXI
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![BU of 2xxi by Molmil](/molmil-images/mine/2xxi) | Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. | 分子名称: | 1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... | 著者 | Ward, S.E, Harries, M, Aldegheri, L, Austin, N.E, Ballantine, S, Ballini, E, Bradley, D.M, Bax, B.D, Clarke, B.P, Harris, A.J, Harrison, S.A, Melarange, R.A, Mookherjee, C, Mosley, J, DalNegro, G, Oliosi, B, Smith, K.J, Thewlis, K.M, Woollard, P.M, Yusaf, S.P. | 登録日 | 2010-11-10 | 公開日 | 2011-04-06 | 最終更新日 | 2011-09-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem., 54, 2011
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4IO7
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2XXW
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![BU of 2xxw by Molmil](/molmil-images/mine/2xxw) | Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate | 分子名称: | CHLORIDE ION, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ... | 著者 | Nayeem, N, Mayans, O, Green, T. | 登録日 | 2010-11-12 | 公開日 | 2011-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
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4IO2
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4L17
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![BU of 4l17 by Molmil](/molmil-images/mine/4l17) | GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX | 分子名称: | 6,7-DINITROQUINOXALINE-2,3-DIONE, Glutamate receptor 2, SULFATE ION | 著者 | Lau, A.Y, Blachowicz, L, Roux, B. | 登録日 | 2013-06-02 | 公開日 | 2013-08-14 | 最終更新日 | 2017-08-02 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A conformational intermediate in glutamate receptor activation. Neuron, 79, 2013
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3DLN
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![BU of 3dln by Molmil](/molmil-images/mine/3dln) | Crystal structure of the binding domain of the AMPA subunit GluR3 bound to glutamate | 分子名称: | GLUTAMIC ACID, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | 登録日 | 2008-06-27 | 公開日 | 2008-11-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
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4JWX
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![BU of 4jwx by Molmil](/molmil-images/mine/4jwx) | GluN2A ligand-binding core in complex with propyl-NHP5G | 分子名称: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, GluN2A | 著者 | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | 登録日 | 2013-03-27 | 公開日 | 2013-05-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors. Mol.Pharmacol., 84, 2013
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3C33
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4H8J
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![BU of 4h8j by Molmil](/molmil-images/mine/4h8j) | Structure of GluA2-LBD in complex with MES | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glutamate receptor 2, ... | 著者 | Reiter, A, Skerra, A, Trauner, D, Schiefner, A. | 登録日 | 2012-09-22 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of an artificial photoreceptor To be Published
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4IO6
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4IGT
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![BU of 4igt by Molmil](/molmil-images/mine/4igt) | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist ZA302 at 1.24A resolution | 分子名称: | (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, GLYCEROL, Glutamate receptor 2, ... | 著者 | Larsen, A.P, Venskutonyte, R, Gajhede, M, Kastrup, J.S, Frydenvang, K. | 登録日 | 2012-12-18 | 公開日 | 2013-03-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. J.Med.Chem., 56, 2013
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4IO4
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![BU of 4io4 by Molmil](/molmil-images/mine/4io4) | Crystal Structure of the AvGluR1 ligand binding domain complex with serine at 1.94 Angstrom resolution | 分子名称: | AvGluR1 ligand binding domain, CHLORIDE ION, GLYCEROL, ... | 著者 | Lomash, S, Chittori, S, Mayer, M.L. | 登録日 | 2013-01-07 | 公開日 | 2013-02-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.941 Å) | 主引用文献 | Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels. Structure, 21, 2013
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4IGR
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![BU of 4igr by Molmil](/molmil-images/mine/4igr) | Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist ZA302 | 分子名称: | (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, CHLORIDE ION, Glutamate receptor, ... | 著者 | Larsen, A.P, Venskutonyte, R, Gajhede, M, Kastrup, J.S, Frydenvang, K. | 登録日 | 2012-12-18 | 公開日 | 2013-03-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. J.Med.Chem., 56, 2013
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4H8I
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![BU of 4h8i by Molmil](/molmil-images/mine/4h8i) | Structure of GluK2-LBD in complex with GluAzo | 分子名称: | (4R)-4-[(2E)-3-{4-[(E)-phenyldiazenyl]phenyl}prop-2-en-1-yl]-L-glutamic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Reiter, A, Skerra, A, Trauner, D, Schiefner, A. | 登録日 | 2012-09-22 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A photoswitchable neurotransmitter analogue bound to its receptor. Biochemistry, 52, 2013
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3DP4
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![BU of 3dp4 by Molmil](/molmil-images/mine/3dp4) | Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA | 分子名称: | (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | 登録日 | 2008-07-07 | 公開日 | 2008-11-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
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4GXS
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![BU of 4gxs by Molmil](/molmil-images/mine/4gxs) | Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin | 分子名称: | (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline, Glutamate receptor 2, ZINC ION | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2012-09-04 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9634 Å) | 主引用文献 | The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2. J.Biol.Chem., 287, 2012
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6U5S
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6UCB
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![BU of 6ucb by Molmil](/molmil-images/mine/6ucb) | GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD, CNIH3, and lipids | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Glutamate receptor 2, ... | 著者 | Nakagawa, T. | 登録日 | 2019-09-15 | 公開日 | 2019-12-04 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structures of the AMPA receptor in complex with its auxiliary subunit cornichon. Science, 366, 2019
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6UD8
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6U6I
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6USV
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![BU of 6usv by Molmil](/molmil-images/mine/6usv) | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and SDZ 220-040 | 分子名称: | (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, GLYCEROL, GLYCINE, ... | 著者 | Romero-Hernandez, A, Tajima, N, Chou, T, Furukawa, h. | 登録日 | 2019-10-28 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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6USU
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![BU of 6usu by Molmil](/molmil-images/mine/6usu) | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with L689,560 and glutamate | 分子名称: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... | 著者 | Romero-Hernandez, A, Tajima, N, Chou, T, Furukawa, H. | 登録日 | 2019-10-28 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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6UZ6
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6UZX
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![BU of 6uzx by Molmil](/molmil-images/mine/6uzx) | Crystal structure of GLUN1/GLUN2A-4M mutant ligand-binding domain in complex with glycine and UBP791 | 分子名称: | (2S,3R)-1-[7-(2-carboxyethyl)phenanthrene-2-carbonyl]piperazine-2,3-dicarboxylic acid, GLYCEROL, GLYCINE, ... | 著者 | Wang, J.X, Furukawa, H. | 登録日 | 2019-11-15 | 公開日 | 2020-01-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nat Commun, 11, 2020
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6UZG
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