4IGR
Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist ZA302
Summary for 4IGR
Entry DOI | 10.2210/pdb4igr/pdb |
Related | 3S9E 4IGT |
Descriptor | Glutamate receptor, ionotropic kainate 3, (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | membrane protein, ionotropic glutamate receptor, kainate receptor, ligand-binding domain, agonist |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P42264 |
Total number of polymer chains | 1 |
Total formula weight | 29549.31 |
Authors | Larsen, A.P.,Venskutonyte, R.,Gajhede, M.,Kastrup, J.S.,Frydenvang, K. (deposition date: 2012-12-18, release date: 2013-03-06, Last modification date: 2023-11-08) |
Primary citation | Assaf, Z.,Larsen, A.P.,Venskutonyte, R.,Han, L.,Abrahamsen, B.,Nielsen, B.,Gajhede, M.,Kastrup, J.S.,Jensen, A.A.,Pickering, D.S.,Frydenvang, K.,Gefflaut, T.,Bunch, L. Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. J.Med.Chem., 56:1614-1628, 2013 Cited by PubMed: 23414088DOI: 10.1021/jm301433m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report