PDB: 596 件ウェブページステータス検索Chemie searchBIRD

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6E8M	Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide 分子名称: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8I	Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine 分子名称: LeSH (Llo2327), O-PHOSPHOTYROSINE 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6E8K	Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide 分子名称: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-30 公開日 2018-11-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6CMS	Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor 分子名称: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CMP	Closed structure of inactive SHP2 mutant C459E 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CMR	Closed structure of active SHP2 mutant E76D bound to SHP099 inhibitor 分子名称: 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6CMQ	Structure of human SHP2 without N-SH2 domain 分子名称: Tyrosine-protein phosphatase non-receptor type 11 著者 Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. 登録日 2018-03-06 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
6E8H	Legionella Longbeachae LeSH (Llo2327) 分子名称: CHLORIDE ION, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6NCT	Structure of p110alpha/niSH2 - vector data collection 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, SULFATE ION, ... 著者 Miller, M.S, Maheshwari, S, Amzel, L.M, Gabelli, S.B. 登録日 2018-12-12 公開日 2019-02-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules, 24, 2019
6MDA	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyridine 4 分子名称: 3-(4-bromophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MD7	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7 分子名称: 2-[4-(aminomethyl)-4-methylpiperidin-1-yl]-5-{[2-(trifluoromethyl)pyridin-3-yl]sulfanyl}pyrimidin-4(3H)-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDB	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 5 分子名称: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-5-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDC	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 1 SHP389 分子名称: 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MDD	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Imidazo-pyridine 24 分子名称: 5-[(2,3-dichlorophenyl)sulfanyl]-3H-imidazo[4,5-b]pyridin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6MD9	NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR Isoxazolo-pyridinone 3 分子名称: 3-(2-chlorophenyl)-6-{4-[(dimethylamino)methyl]phenyl}-5-methyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
6I4X	Crystal structure of SOCS2:Elongin C:Elongin B in complex with erythropoietin receptor peptide 分子名称: DI(HYDROXYETHYL)ETHER, Elongin-B, Elongin-C, ... 著者 Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. 登録日 2018-11-12 公開日 2019-05-29 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019
6I5N	Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide 分子名称: COBALT (II) ION, Elongin-B, Elongin-C, ... 著者 Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. 登録日 2018-11-14 公開日 2019-05-29 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019
6I5J	Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide 分子名称: COBALT (II) ION, Elongin-B, Elongin-C, ... 著者 Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. 登録日 2018-11-13 公開日 2019-05-29 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019
6JMF	Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4 分子名称: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide, SULFATE ION, Tyrosine-protein kinase Fes/Fps 著者 Baba, D, Hanzawa, H. 登録日 2019-03-08 公開日 2019-06-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. Acs Med.Chem.Lett., 10, 2019
6QHD	Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA 分子名称: DNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3 著者 Arbely, E, Belo, Y, Shahar, A, Zarivach, R. 登録日 2019-01-16 公開日 2019-06-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochim Biophys Acta Gen Subj, 1863, 2019
6MBZ	Structure of Transcription Factor 分子名称: Signal transducer and activator of transcription 5B 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2018-08-30 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural and functional consequences of the STAT5BN642Hdriver mutation. Nat Commun, 10, 2019
6MBW	Structure of Transcription Factor 分子名称: Signal transducer and activator of transcription 5B 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2018-08-30 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 Structural and functional consequences of the STAT5BN642H driver mutation. Nat Commun, 10, 2019
6ICH	Grb2 SH2 domain in domain swapped dimer form 分子名称: Growth factor receptor-bound protein 2 著者 Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2018-09-06 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
6ICG	Grb2 SH2 domain in phosphopeptide free form 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION 著者 Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2018-09-06 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
6KC4	Crystal structure of human Fer SH2 domain bound to a phosphopeptide (DEpYENVD) 分子名称: Tyrosine-protein kinase Fer, phosphopeptide (EDpYENVD) 著者 Matsuura, Y. 登録日 2019-06-27 公開日 2019-09-04 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase. Protein Sci., 28, 2019

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