PDB: 215264 件ウェブページステータス検索Chemie searchBIRD

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1LCO	X-RAY STRUCTURE OF TWO COMPLEXES OF THE Y143F FLAVOCYTOCHROME B2 MUTANT CRYSTALLIZED IN THE PRESENCE OF LACTATE OR PHENYL-LACTATE 分子名称: 3-PHENYLPYRUVIC ACID, FLAVIN MONONUCLEOTIDE, L-LACTATE DEHYDROGENASE, ... 著者 Tegoni, M, Cambillau, C. 登録日 1995-03-30 公開日 1995-09-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 X-ray structure of two complexes of the Y143F flavocytochrome b2 mutant crystallized in the presence of lactate or phenyl lactate. Biochemistry, 34, 1995
4O9B	The Structure of CC1-IH in human STIM1. 分子名称: CADMIUM ION, Stromal interaction molecule 1 著者 Cui, B, Yang, X, Li, S, Shen, Y. 登録日 2014-01-02 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.604 Å) 主引用文献 The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. Plos One, 8, 2013
5VUA	Pim1 Kinase in complex with a benzofuranone inhibitor 分子名称: (2Z)-6-methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[2,3-c]pyridin-3-ylmethylidene)-1-benzofuran-3-one, GLYCEROL, PHOSPHATE ION, ... 著者 Parker, L.J. 登録日 2017-05-18 公開日 2017-12-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Theoretical Analysis of Activity Cliffs among Benzofuranone-Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach J Chem Inf Model, 57, 2017
1YVF	Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145 分子名称: (2Z)-2-(BENZOYLAMINO)-3-[4-(2-BROMOPHENOXY)PHENYL]-2-PROPENOIC ACID, CHLORIDE ION, GLYCEROL, ... 著者 Pfefferkorn, J.A, Greene, M.L, Nugent, R.A, Gross, R.J, Mitchell, M.A, Finzel, B.C, Harris, M.S, Wells, P.A, Shelly, J.A, Anstadt, R.A, Kilkuskie, R.E, Kopta, L.A, Schwende, F.J. 登録日 2005-02-15 公開日 2005-04-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg.Med.Chem.Lett., 15, 2005
6KU7	structure of HRV-C 3C protein 分子名称: Genome polyprotein 著者 Zhu, L, Yuan, S. 登録日 2019-08-31 公開日 2020-03-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin, 35, 2020
2XWN	Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg 分子名称: 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Bjorkelid, C, Bergfors, T, Unge, T, Jones, T.A. 登録日 2010-11-04 公開日 2011-04-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural and Functional Studies on Mycobacterial Ispd Enzymes Acta Crystallogr.,Sect.D, 67, 2011
5W0F	CREBBP Bromodomain in complex with Cpd3 ((S)-1-(3-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) 分子名称: 1-{3-[6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein 著者 Murray, J.M. 登録日 2017-05-30 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J. Med. Chem., 60, 2017
5W0L	CREBBP Bromodomain in complex with Cpd10 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) 分子名称: 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein 著者 Murray, J.M. 登録日 2017-05-31 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.549 Å) 主引用文献 GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J. Med. Chem., 60, 2017
2PA1	Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin 分子名称: CHLORIDE ION, PDZ and LIM domain protein 2 著者 Uppenberg, J, Shrestha, L, Elkins, J, Burgess-Brown, N, Salah, E, Bunkoczi, G, Papagrigoriou, E, Pike, A.C.W, Turnbull, A.P, Ugochukwu, E, Umeano, C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2007-03-27 公開日 2007-05-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms Protein Sci., 19, 2010
1SB0	Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb 分子名称: protein CBP, protein c-Myb 著者 Zor, T, De Guzman, R.N, Dyson, H.J, Wright, P.E. 登録日 2004-02-09 公開日 2004-04-13 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of c-Myb J.Mol.Biol., 337, 2004
1LXF	Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin-I(147-163) and Bepridil 分子名称: 1-ISOBUTOXY-2-PYRROLIDINO-3[N-BENZYLANILINO] PROPANE, CALCIUM ION, TROPONIN C, ... 著者 Wang, X, Li, M.X, Sykes, B.D. 登録日 2002-06-05 公開日 2002-12-11 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil. J.Biol.Chem., 277, 2002
3H2L	Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor 分子名称: N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase 著者 Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R. 登録日 2009-04-14 公開日 2009-12-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
1QUV	CRYSTAL STRUCTURE OF THE RNA DIRECTED RNA POLYMERASE OF HEPATITIS C VIRUS 分子名称: PROTEIN (RNA-DIRECTED RNA POLYMERASE) 著者 Ago, H, Miyano, M, Adachi, T, Habuka, N. 登録日 1999-07-04 公開日 1999-11-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure Fold.Des., 7, 1999
3GPW	Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: irreversible inhibitor ligand 分子名称: (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Proteasome component C1, Proteasome component C11, ... 著者 Groll, M, Macherla, V.R, Manam, R.R, Arthur, K.A.M, Potts, C.B. 登録日 2009-03-23 公開日 2009-09-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition J.Med.Chem., 52, 2009
1BEK	EFFECT OF UNNATURAL HEME SUBSTITUTION ON KINETICS OF ELECTRON TRANSFER IN CYTOCHROME C PEROXIDASE 分子名称: PROTOPORPHYRIN IX CONTAINING FE, YEAST CYTOCHROME C PEROXIDASE 著者 Miller, M.A, Kraut, J. 登録日 1998-05-16 公開日 1998-10-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Effect of Unnatural Heme Substitution on Kinetics of Electron Transfer in Cytochrome C Peroxidase To be Published
4BV4	Structure and allostery in Toll-Spatzle recognition 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN SPAETZLE C-106, PROTEIN TOLL, ... 著者 Lewis, M.F, Arnot, C.J, Beeston, H, McCoy, A, Ashcroft, A.E, Gay, N.J, Gangloff, M. 登録日 2013-06-24 公開日 2013-12-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Cytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation. Proc.Natl.Acad.Sci.USA, 110, 2013
5RAP	PanDDA analysis group deposition -- Crystal Structure of JMJD1B in complex with FM000707a 分子名称: (3~{a}~{R},7~{a}~{R})-4-(4-methoxyphenyl)-2,3,3~{a},6,7,7~{a}-hexahydrothieno[3,2-c]pyridine, CHLORIDE ION, Lysine-specific demethylase 3B, ... 著者 Snee, M, Nowak, R, Johansson, C, Burgess-Brown, N.A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2020-03-16 公開日 2020-04-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 PanDDA analysis group deposition of Human JMJD1B screened against the DSPL Fragment Library To Be Published
4NLN	Structure of human DNA polymerase beta complexed with nicked DNA containing a template 8BrG and incoming CTP 分子名称: 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... 著者 Koag, M.-C, Min, K, Monzingo, A.F, Lee, S. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.261 Å) 主引用文献 Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289, 2014
6LFZ	Crystal structure of SbCGTb in complex with UDPG 分子名称: SbCGTb, URIDINE-5'-DIPHOSPHATE-GLUCOSE 著者 Gao, H.M, Yun, C.H. 登録日 2019-12-04 公開日 2020-11-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.866 Å) 主引用文献 Dissection of the general two-step di- C -glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc.Natl.Acad.Sci.USA, 117, 2020
1SLN	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-702,842 分子名称: CALCIUM ION, N-(R-CARBOXY-ETHYL)-ALPHA-(S)-(2-PHENYLETHYL)GLYCYL-L-ARGININE-N-PHENYLAMIDE, STROMELYSIN-1, ... 著者 Becker, J.W. 登録日 1995-08-03 公開日 1996-12-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme. Protein Sci., 4, 1995
4I99	Crystal structure of the SmcHead bound to the C-winged helix domain of ScpA 分子名称: Chromosome partition protein Smc, PHOSPHATE ION, Putative uncharacterized protein 著者 Shin, H.C, Soh, Y.M, Oh, B.H. 登録日 2012-12-05 公開日 2013-01-30 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 An asymmetric SMC-kleisin bridge in prokaryotic condensin. Nat.Struct.Mol.Biol., 20, 2013
3V3C	Crystal Structure of Chloroplast ATP synthase c-ring from Pisum sativum 分子名称: ATP synthase subunit c, chloroplastic, DIGALACTOSYL DIACYL GLYCEROL (DGDG), ... 著者 Saroussi, S, Nelson, N. 登録日 2011-12-13 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.402 Å) 主引用文献 Structure and flexibility of the C-ring in the electromotor of rotary F(o)F(1)-ATPase of pea chloroplasts. Plos One, 7, 2012
4FW2	Crystal structure of RSV three-domain integrase with disordered N-terminal domain 分子名称: Integrase 著者 Shi, K, Aihara, H. 登録日 2012-06-29 公開日 2013-05-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding. Plos One, 8, 2013
4G7X	Crystal structure of a complex between the CTXphi pIII N-terminal domain and the Vibrio cholerae TolA C-terminal domain 分子名称: Putative uncharacterized protein, TolA protein 著者 Kolappan, S, Ford, C.G, Craig, L. 登録日 2012-07-20 公開日 2012-08-29 最終更新日 2012-11-07 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Crystal Structures of a CTX{varphi} pIII Domain Unbound and in Complex with a Vibrio cholerae TolA Domain Reveal Novel Interaction Interfaces. J.Biol.Chem., 287, 2012
4KFN	Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors 分子名称: 1,2-ETHANEDIOL, N-[4-(piperidin-1-ylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... 著者 Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Gunzner-Toste, J, Liederer, B.M, Ly, J, O'Brien, T, Oh, A, Wang, L, Wang, W, Xiao, Y, Zak, M, Zhao, G, Yuen, P, Bair, K.W. 登録日 2013-04-27 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56, 2013

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