2KO3
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![BU of 2ko3 by Molmil](/molmil-images/mine/2ko3) | Nedd8 solution structure | 分子名称: | NEDD8 | 著者 | Choi, Y.S, Jeon, Y.H, Cheong, C. | 登録日 | 2009-09-09 | 公開日 | 2009-11-03 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | 60th residues of ubiquitin and Nedd8 are located out of E2-binding surfaces, but are important for K48 ubiquitin-linkage. Febs Lett., 583, 2009
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2KR0
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2KBM
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![BU of 2kbm by Molmil](/molmil-images/mine/2kbm) | Ca-S100A1 interacting with TRTK12 | 分子名称: | CALCIUM ION, F-actin-capping protein subunit alpha-2, Protein S100-A1 | 著者 | Wright, N.T, Varney, K.M, Cannon, B.R, Morgan, M, Weber, D.J. | 登録日 | 2008-12-02 | 公開日 | 2009-02-10 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of Ca-S100A1-TRTK12 To be Published
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8AEL
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![BU of 8ael by Molmil](/molmil-images/mine/8ael) | SYNJ2BP complex with a synthetic Vangl2 peptide (3mer). | 分子名称: | CALCIUM ION, GLY-GLY-GLY-THR-SER-VAL, GLYCEROL, ... | 著者 | Carrasco, K, Cousido Siah, A, Gogl, G, Betzi, S, McEwen, A, Kostmann, C, Trave, G. | 登録日 | 2022-07-13 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide. To Be Published
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1BBY
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![BU of 1bby by Molmil](/molmil-images/mine/1bby) | DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, MINIMIZED AVERAGE | 分子名称: | RAP30 | 著者 | Groft, C.M, Uljon, S.N, Wang, R, Werner, M.H. | 登録日 | 1998-04-26 | 公開日 | 1998-11-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. Proc.Natl.Acad.Sci.USA, 95, 1998
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8V7L
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![BU of 8v7l by Molmil](/molmil-images/mine/8v7l) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-12-04 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V6V
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![BU of 8v6v by Molmil](/molmil-images/mine/8v6v) | Cryo-EM structure of doubly-bound SNF2h-nucleosome complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-12-03 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V4Y
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![BU of 8v4y by Molmil](/molmil-images/mine/8v4y) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Histone H2A type 1, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-11-29 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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6HTS
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![BU of 6hts by Molmil](/molmil-images/mine/6hts) | Cryo-EM structure of the human INO80 complex bound to nucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | 著者 | Ayala, R, Willhoft, O, Aramayo, R.J, Wilkinson, M, McCormack, E.A, Ocloo, L, Wigley, D.B, Zhang, X. | 登録日 | 2018-10-04 | 公開日 | 2018-11-07 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structure and regulation of the human INO80-nucleosome complex. Nature, 556, 2018
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6LTH
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![BU of 6lth by Molmil](/molmil-images/mine/6lth) | Structure of human BAF Base module | 分子名称: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | 登録日 | 2020-01-22 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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8TOF
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![BU of 8tof by Molmil](/molmil-images/mine/8tof) | Rpd3S bound to an H3K36Cme3 modified nucleosome | 分子名称: | Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... | 著者 | Markert, J.W, Vos, S.M, Farnung, L. | 登録日 | 2023-08-03 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Nat Commun, 14, 2023
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7EG6
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![BU of 7eg6 by Molmil](/molmil-images/mine/7eg6) | Snf5 Finger Helix bound to the nucleosome | 分子名称: | DNA (235-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Chen, Z.C, Chen, K.J, He, Z.Y, Ye, Y.P. | 登録日 | 2021-03-24 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity. Cell Discov, 7, 2021
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6VZ4
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4R3C
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![BU of 4r3c by Molmil](/molmil-images/mine/4r3c) | Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, CHLORIDE ION, ... | 著者 | Grum-Tokars, V.L, Minasov, G, Roy, S.M, Anderson, W.F, Watterson, D.M. | 登録日 | 2014-08-14 | 公開日 | 2015-02-25 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci, 6, 2015
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7U50
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6TWY
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![BU of 6twy by Molmil](/molmil-images/mine/6twy) | MAGI1_2 complexed with a phosphomimetic RSK1 peptide | 分子名称: | CALCIUM ION, CITRIC ACID, GLYCEROL, ... | 著者 | Gogl, G, Cousido-Siah, A, Trave, G. | 登録日 | 2020-01-13 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
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7VVZ
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![BU of 7vvz by Molmil](/molmil-images/mine/7vvz) | NuA4 bound to the nucleosome | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... | 著者 | Qu, K, Chen, Z. | 登録日 | 2021-11-09 | 公開日 | 2022-08-10 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (8.8 Å) | 主引用文献 | Structure of the NuA4 acetyltransferase complex bound to the nucleosome. Nature, 610, 2022
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4W9E
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![BU of 4w9e by Molmil](/molmil-images/mine/4w9e) | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 4) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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8F86
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![BU of 8f86 by Molmil](/molmil-images/mine/8f86) | SIRT6 bound to an H3K9Ac nucleosome | 分子名称: | DNA (148-MER), Histone H2A type 1, Histone H2B, ... | 著者 | Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. | 登録日 | 2022-11-21 | 公開日 | 2023-04-05 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. J.Am.Chem.Soc., 145, 2023
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4W9J
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![BU of 4w9j by Molmil](/molmil-images/mine/4w9j) | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-4-methylpentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 13) | 分子名称: | N-acetyl-L-leucyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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7NTF
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4W9L
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![BU of 4w9l by Molmil](/molmil-images/mine/4w9l) | pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15) | 分子名称: | N-acetyl-3-methyl-L-valyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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4W9F
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![BU of 4w9f by Molmil](/molmil-images/mine/4w9f) | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 5) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | van Molle, I, Hewitt, S, Galdeano, C, Gadd, M.S, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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8PLZ
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![BU of 8plz by Molmil](/molmil-images/mine/8plz) | Cryo-EM structure of CAK in complex with inhibitor CT7030 | 分子名称: | (3~{R},4~{R})-4-[[[7-[(2-methoxyphenyl)methylamino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-06-27 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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1BC7
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![BU of 1bc7 by Molmil](/molmil-images/mine/1bc7) | SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX | 分子名称: | DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*TP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*AP*GP*GP*AP*TP*GP*TP*G)-3'), PROTEIN (ETS-DOMAIN PROTEIN) | 著者 | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | 登録日 | 1998-05-05 | 公開日 | 1999-01-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. Mol.Cell, 2, 1998
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