6ECO
 
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6R4G
 | | Crystal structure of human GFAT-1 in complex with UDP-GlcNAc | | 分子名称: | GLUCOSE-6-PHOSPHATE, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, MAGNESIUM ION, ... | | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | | 登録日 | 2019-03-22 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
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8CJ7
 | | HDAC6 selective degraded (difluoromethyl)-1,3,4-oxadiazole substrate inhibitor | | 分子名称: | 6-[(5-pyridin-2-yl-1,2$l^{4},3,4-tetrazacyclopenta-1,3-dien-2-yl)methyl]pyridine-3-carbohydrazide, Histone deacetylase 6, IODIDE ION, ... | | 著者 | Sandmark, J, Ek, M, Ripa, L. | | 登録日 | 2023-02-12 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
J.Med.Chem., 66, 2023
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6KZO
 | | membrane protein | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Yan, N. | | 登録日 | 2019-09-25 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
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5K72
 | | IRAK4 in complex with Compound 21 | | 分子名称: | Interleukin-1 receptor-associated kinase 4, SULFATE ION, ~{N}4,~{N}4-dimethyl-~{N}1-[5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | | 著者 | Ferguson, A.D. | | 登録日 | 2016-05-25 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
J. Med. Chem., 60, 2017
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9EW8
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8VBI
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VBF
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (40-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VBE
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (39-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VBH
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8A3D
 | | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | | 分子名称: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Faille, A, Warren, A.J, Dent, K.C. | | 登録日 | 2022-06-08 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (1.67 Å) | | 主引用文献 | The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
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8VBG
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VB8
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VB9
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VBC
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VB6
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, HIV-1 reverse transcriptase/ribonuclease H P66 subunit | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VB7
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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8VBD
 | | Kinetic intermediate states of HIV-1 RT DNA synthesis captured by cryo-EM | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (38-MER), HIV-1 reverse transcriptase P51 subunit, ... | | 著者 | Vergara, S, Zhou, X, Santiago, U, Conway, J.F, Sluis-Cremer, N, Calero, G. | | 登録日 | 2023-12-12 | | 公開日 | 2024-12-11 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription.
Nat Commun, 15, 2024
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9C2K
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8F0S
 | | Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C. | | 登録日 | 2022-11-03 | | 公開日 | 2023-04-12 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
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7TC2
 | | Human APE1 in complex with 5-nitroindole-2-carboxylic acid | | 分子名称: | 1,2-ETHANEDIOL, 5-nitro-1H-indole-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pidugu, L.S, Pozharski, E, Drohat, A.C. | | 登録日 | 2021-12-22 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Characterizing inhibitors of human AP endonuclease 1.
Plos One, 18, 2023
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6WAP
 | | Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR | | 分子名称: | HIV-1 capsid protein | | 著者 | Lu, M, Russell, R.W, Bryer, A, Quinn, C.M, Hou, G, Zhang, H, Schwieters, C.D, Perilla, J.R, Gronenborn, A.M, Polenova, T. | | 登録日 | 2020-03-25 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR.
Nat.Struct.Mol.Biol., 27, 2020
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6TSE
 | | Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C | | 分子名称: | 1-methylindole-2,3-dione, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... | | 著者 | Brear, P, Wagstaff, J, Hyvonen, M. | | 登録日 | 2019-12-20 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
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6EQM
 | | Crystal Structure of Human BACE-1 in Complex with CNP520 | | 分子名称: | Beta-secretase 1, ~{N}-[6-[(3~{R},6~{R})-5-azanyl-3,6-dimethyl-6-(trifluoromethyl)-2~{H}-1,4-oxazin-3-yl]-5-fluoranyl-pyridin-2-yl]-3-chloranyl-5-(trifluoromethyl)pyridine-2-carboxamide | | 著者 | Rondeau, J.-M, Wirth, E. | | 登録日 | 2017-10-13 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
EMBO Mol Med, 10, 2018
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6E8P
 | | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49 | | 分子名称: | (14beta,17beta)-estra-1(10),2,4,6,8-pentaene-3,17-diyl disulfamate, Carbonic anhydrase 2, ZINC ION | | 著者 | Andring, J.T, Mckenna, R. | | 登録日 | 2018-07-30 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | 3,17 beta-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
J. Med. Chem., 62, 2019
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