8F0S

Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296

Summary for 8F0S

• Entry DOI: 10.2210/pdb8f0s/pdb
• EMDB information: 28779
• Descriptor: Sodium channel protein PaFPC1,Sodium channel protein type 9 subunit alpha chimera, Beta-diguetoxin-Dc1a, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: ion channel, small molecule, inhibitor, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 196743.09

Authors

Kschonsak, M.,Jao, C.C.,Arthur, C.P.,Rohou, A.L.,Bergeron, P.,Ortwine, D.,McKerall, S.J.,Hackos, D.H.,Deng, L.,Chen, J.,Sutherlin, D.,Dragovich, P.S.,Volgraf, M.,Wright, M.R.,Payandeh, J.,Ciferri, C.,Tellis, J.C. (deposition date: 2022-11-03, release date: 2023-04-12)

• Primary citation: Kschonsak, M.,Jao, C.C.,Arthur, C.P.,Rohou, A.L.,Bergeron, P.,Ortwine, D.F.,McKerrall, S.J.,Hackos, D.H.,Deng, L.,Chen, J.,Li, T.,Dragovich, P.S.,Volgraf, M.,Wright, M.R.,Payandeh, J.,Ciferri, C.,Tellis, J.C.; Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.; Elife, 12:-, 2023; PubMed: 36975198; DOI: 10.7554/eLife.84151

Experimental method

ELECTRON MICROSCOPY (3.1 Å)