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8F0S

Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296

Functional Information from GO Data
ChainGOidnamespacecontents
A0001518cellular_componentvoltage-gated sodium channel complex
A0005216molecular_functionmonoatomic ion channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0016020cellular_componentmembrane
A0055085biological_processtransmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues261
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues117
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues87
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues88
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues13
DetailsRegion: {"description":"Linker region that may regulate channel inactivation","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A91","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A95","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues7
DetailsSite: {"description":"Interacts with the spider Mu-diguetoxin-Dc1a","evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues5
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A95","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues82
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues50
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI56
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI57
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI58
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI59
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI60
Number of Residues1
DetailsSite: {"description":"Is directly targeted by the spider protoxin-II","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI61
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"25240195","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI62
Number of Residues7
DetailsSite: {"description":"Interacts with insect Nav channel","evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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