8F0S
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001518 | cellular_component | voltage-gated sodium channel complex |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005248 | molecular_function | voltage-gated sodium channel activity |
A | 0005261 | molecular_function | monoatomic cation channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006814 | biological_process | sodium ion transport |
A | 0016020 | cellular_component | membrane |
A | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 261 |
Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 117 |
Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 17 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 87 |
Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI13 |
Number of Residues | 20 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI14 |
Number of Residues | 17 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI15 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI16 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI18 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI19 |
Number of Residues | 21 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI20 |
Number of Residues | 17 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI21 |
Number of Residues | 88 |
Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI22 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI23 |
Number of Residues | 17 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI24 |
Number of Residues | 16 |
Details | Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI25 |
Number of Residues | 17 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI26 |
Number of Residues | 22 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI27 |
Number of Residues | 13 |
Details | Region: {"description":"Linker region that may regulate channel inactivation","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000303"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI28 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A91","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI29 |
Number of Residues | 5 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A95","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI30 |
Number of Residues | 7 |
Details | Site: {"description":"Interacts with the spider Mu-diguetoxin-Dc1a","evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI31 |
Number of Residues | 3 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8J","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI32 |
Number of Residues | 5 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A95","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI33 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI34 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI35 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI36 |
Number of Residues | 21 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI37 |
Number of Residues | 82 |
Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI38 |
Number of Residues | 18 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI39 |
Number of Residues | 16 |
Details | Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI40 |
Number of Residues | 25 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI41 |
Number of Residues | 50 |
Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI42 |
Number of Residues | 25 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI43 |
Number of Residues | 16 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI44 |
Number of Residues | 24 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI45 |
Number of Residues | 16 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI46 |
Number of Residues | 22 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI47 |
Number of Residues | 26 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI48 |
Number of Residues | 24 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI49 |
Number of Residues | 25 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI50 |
Number of Residues | 25 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI51 |
Number of Residues | 16 |
Details | Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI52 |
Number of Residues | 24 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI53 |
Number of Residues | 25 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI54 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI55 |
Number of Residues | 21 |
Details | Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI56 |
Number of Residues | 21 |
Details | Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI57 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI58 |
Number of Residues | 22 |
Details | Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI59 |
Number of Residues | 25 |
Details | Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI60 |
Number of Residues | 1 |
Details | Site: {"description":"Is directly targeted by the spider protoxin-II","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI61 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"25240195","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI62 |
Number of Residues | 7 |
Details | Site: {"description":"Interacts with insect Nav channel","evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |